Luiz Pedro Carvalho, PhD's Avatar

Luiz Pedro Carvalho, PhD

@luizcarvalholab.bsky.social

Professor of Chemistry @UFScripps Interested in enzymology, bacterial metabolism, chem bio, mycobacteria, antibiotic discovery and antibiotic resistance. Former group leader at NIMR and The Crick.

1,299 Followers  |  1,665 Following  |  23 Posts  |  Joined: 13.11.2024  |  1.9537

Latest posts by luizcarvalholab.bsky.social on Bluesky

Mycobacterium tuberculosis partitions the Krebs cycle to persist under iron starvation

Out now in @elife.bsky.social elifesciences.org/reviewed-pre...

Agnese Serafini @agnese75.bsky.social back in Italy discovered that Mtb splits its Krebs cycle during extreme iron starvation. An unprecedented mechanism to work around nutritional immunity and persist. More cool stuff in there too...

07.08.2025 16:57 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
The Past, Present and Future of Immunology Research โ€“ with Caetano Reis e Sousa
YouTube video by Francis Crick Institute The Past, Present and Future of Immunology Research โ€“ with Caetano Reis e Sousa

My "Crash Course in โ€ฆImmunology" is now posted on YouTube youtu.be/nBC9vvlTxF8. Taken from a public lecture @crick.ac.uk on history and basic concepts in immunity. Aimed at the lay public and those seeking an introductory overview.

04.08.2025 20:11 โ€” ๐Ÿ‘ 36    ๐Ÿ” 10    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Peptidoglycanโ€“outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

What an amazing paper and findings. Congrats to Jean-Franรงois Collet and colleagues.

www.nature.com/articles/s41...

31.07.2025 19:41 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA) Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...

๐ŸšจNew pre-print ๐Ÿšจ
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec

This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n

www.biorxiv.org/content/10.1...

23.07.2025 10:50 โ€” ๐Ÿ‘ 22    ๐Ÿ” 12    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Combating Tuberculosis: Obstacles, Innovations, and the Road Ahead Tuberculosis (TB) remains one of the worldโ€™s leading infectious diseases. Every year on March 24th, World Tuberculosis Day is observed, which in 1882 is when Robert Koch announced the discovery of Mycobacterium tuberculosis (Mtb) as the causative agent of TB. This Special Issue features 30 original research articles, perspectives, and reviews from researchers representing 11 countries across all six major continents. ACS Infectious Diseases hopes this special issue encourages our readers to explore the wide range of research showcasing advances in drug discovery and a greater understanding of TB biology.

For the Mtb-focused colleagues, if you haven't seen this issue of ACS Infectious Diseases yet, you can find it here. Lots of good stuff in there.

pubs.acs.org/page/aidcbc/...

15.07.2025 14:08 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

23.06.2025 17:31 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Absorption and fluorescence emission spectra, crystal structure, time-resolved fluorescence data and excited state proton transfer model for a new flavin-binding protein

Absorption and fluorescence emission spectra, crystal structure, time-resolved fluorescence data and excited state proton transfer model for a new flavin-binding protein

Happy to present a new flavin-binding protein that unexpectedly displays a large Stokes shift due to excited state proton transfer. Not submitted yet - feedback is welcome!

doi.org/10.1101/2025...

17.06.2025 09:12 โ€” ๐Ÿ‘ 8    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament - Nature Communications Cyclodipeptide oxidases are filamentous enzymes. Here, the authors dissect the mechanism of a promiscuous flavoenzyme from the biosynthesis of cyclodipeptide natural products, unveiling fast catalysis...

Very cool and broadly useful FMN-dependent enzyme.

www.nature.com/articles/s41...

29.05.2025 12:13 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence | PNAS The underlying factors that lead to specific strains within a species to emerge as human pathogens remain mostly enigmatic. The diarrheal disease c...

Allelic variations and gene cluster modularity act as nonlinear bottlenecks for #cholera emergence www.pnas.org/doi/10.1073/...

29.05.2025 10:19 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Delighted to share our newest pre-print. Here, we describe a very short synthesis (11 steps, LLS) of the polyether antibiotic lasalocid acid A.
doi.org/10.26434/che...

29.05.2025 11:44 โ€” ๐Ÿ‘ 8    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Third track model for coordination of septal peptidoglycan synthesis and degradation by FtsN in Escherichia coli - Nature Microbiology Partitioning of FtsN and the septal peptidoglycan synthesis complex between an active synthesis track and an inactive denuded glycan track coordinates opposing peptidoglycan synthesis and degradation ...

๐Ÿšจ Out now!

A new study showing a third track for coordination of septal peptidoglycan synthesis and degradation by FtsN in E. coli

#MicroSky ๐Ÿฆ ๐Ÿงช

www.nature.com/articles/s41...

28.05.2025 15:44 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Francesca Ciccarelli @ciccarellilab.bsky.social is up next to tell us about spatial drivers of response to immunotherapy in colon cancer

Thank you to TransnetYX for sponsoring Francescaโ€™s talk!

@qmbci.bsky.social | @crick.ac.uk | @cruk-cityoflondon.bsky.social | #BICC2025

28.05.2025 11:18 โ€” ๐Ÿ‘ 11    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Associate or Senior Editor Nature Metabolism Job Title: Associate or Senior Editor Nature Metabolism Location: New York or Shanghai Application Deadline: June 10th, 2025 About Springer Nature Group Springer Nature opens the doors to discovery for researchers, educators, clinicians and other professionals. Every day, around the globe, our imprints, books, journals, platforms and technology solutions reach millions of people. For over 180 years our brands and imprints have been a trusted source of knowledge to these communities and today, more than ever, we see it as our responsibility to ensure that fundamental knowledge can be found, verified, understood and used by our communities โ€“ enabling them to improve outcomes, make progress, and benefit the generations that follow. Visit http://group.springernature.com/ and follow @SpringerNature / @SpringerNatureGroup. About the Brand Nature Portfolio is a flagship portfolio of journals, products and services including Nature and the Nature-branded journals, dedicated to serving the scientific community. Visit nature.com and follow @Nature / @NaturePortfolio. About the Role Nature Metabolism seeks an Associate or Senior Editor to join our expanding editorial team. Do you love science but feel that a research career isnโ€™t enough to sate your desire to learn more about the natural world? Do you enjoy reading papers outside your chosen area of research? If the answer is โ€˜yesโ€™ to any or both questions, you could be the person weโ€™re looking for to join the editorial team ofโ€ฏNature Metabolism. This role can be in our New York or Shanghai offices on a hybrid working model. Role Responsibilities: Working closely with other editors on all aspects of the editorial process, including manuscript selection and overseeing peer review. Commissioning and editing News & Views and Reviews articles and writing for the journal. Organizing and attending conferences and visiting laboratories. Maintaining close contact with the international scientific community. The role requires broad scientific interest and strong interpersonal, communication, and organizational skills. Fluency in spoken and written English, along with a willingness to learn and engage with the scientific community, is essential. Experience, Skills & Qualifications: A Ph.D. in a relevant research field is required. Postdoctoral research experience is preferred but not essential A broad interest in science and the ability to critically evaluate research submitted to the journal Applications from all scientific areas covered by the journal are welcome but candidates with expertise in cellular metabolic biology (e.g. mitochondrial biology), metabolic biochemistry or metabolic tracing are especially encouraged. Experience in cancer research or immunology is a plus. Excellent interpersonal, communication and organizational skills Fluent in spoken and written English To Apply: Please submit a cover letter explaining your interest in the position and your salary expectations please submit a CV concise (up to 500 words) discussion of recent developments or trends in the wider metabolism field, which you have found particularly exciting (and explaining why). Springer Nature US provides a comprehensive and competitive benefits package which includes the benefit offerings listed below: โ€ข Medical, Dental and Vision โ€ข 401(k) with company match and contribution โ€ข Hybrid office working policy, Summer Hours, and paid time off โ€ข Flexible Spending and Commuter programs โ€ข Multiple Life insurance options โ€ข Disability coverage โ€ข Tuition Assistance โ€ข Voluntary benefits: Identity Theft Protection, Pet Insurance, and Legal Assistance Insurance โ€ข Employee Assistance Program โ€ข Family friendly benefits and a variety of employee discounts โ€ข An array of Employee Social Networks US Annualized Base Salary Range: Associate Editor: $80,000 | Senior Editor: $95,000. The salary offer may vary based on work experience, education, skill level and equity. The US salary range does not align with the salary ranges in other countries when converted to the currency of that country. Springer Nature is an Equal Opportunity Employer that complies with the laws and regulations set forth in the following https://www.eeoc.gov/sites/default/files/2023-06/22-088_EEOC_KnowYourRights6.12ScreenRdr.pdf At Springer Nature, we value the diversity of our teams and work to build an inclusive culture, where people are treated fairly and can bring their differences to work and thrive. We empower our colleagues and value their diverse perspectives as we strive to attract, nurture and develop the very best talent. Springer Nature was awarded Diversity Team of the Year at the 2022 British Diversity Awards. Find out more about our DEI work here: https://group.springernature.com/gp/group/taking-responsibility/diversity-equity-inclusion If you have any access needs related to disability, neurodivergence or a chronic condition, please contact us so we can make all necessary accommodation. For more information about career opportunities in Springer Nature please visit https://careers.springernature.com/ #LI-DT1 Job Posting End Date: 11-06-2025 We are an ambitious and dynamic organisation, and home to some of the best-known names in research, educational and professional publishing. Working at the heart of a changing industry, we are always looking for great people who care about delivering quality to our customers and the communities we work alongside. In return, you will find that we open the doors to discovery for all our employees โ€“ offering opportunities to learn from some of the best in the business, with a culture that encourages curiosity and empowers people to find solutions and act on their instincts. Whether you are at the beginning of your career or are an experienced professional, we invite you to find out more about the roles we offer and explore our current vacancies. We are a global and progressive business, founded on a heritage of trusted and respected brands โ€“ including Springer, founded in 1842, Macmillan, founded in 1843 and Nature, first published in 1869. Nearly two centuries of progress and advancement in science and education have helped shape the business we are today. Research and learning continues to be the cornerstone of progress, and we will continue to open doors to discovery through trusted brands and innovative products and services. Springer Nature Group was created in May 2015 through the combination of Nature Publishing Group, Macmillan Education and Springer Science+Business Media.

๐ŸšจJob Alert!๐Ÿšจ

@natmetabolism.nature.comโ€ฌ seeks an Associate or Senior #Editor to join our team. If being a #Metabolism Editor is for you, and you are based in, or open to moving to New York or Shanghai, check out our #job posting below and apply before June 11th!

22.05.2025 16:25 โ€” ๐Ÿ‘ 4    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

Awesome! Thanks Kat.

22.05.2025 14:53 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Very cool and useful, no doubt. It would be great to see M. tuberculosis and perhaps other important mycobacterial pathogens there too.

22.05.2025 11:41 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules

22.05.2025 09:35 โ€” ๐Ÿ‘ 42    ๐Ÿ” 33    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 4
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๐Ÿ”ฅ ๐’๐š๐ฏ๐ž ๐ญ๐ก๐ž ๐ƒ๐š๐ญ๐ž: ๐Ÿ–๐ญ๐ก ๐Ž๐œ๐ญ๐จ๐›๐ž๐ซ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ“ ๐Ÿ”ฅ
NDIยณ & NordInfect join forces in organizing the 2025 Northern Germany Meeting on Infection, Immunology & Inflammation at @fzborstel.bsky.social
๐Š๐ž๐ฒ๐ง๐จ๐ญ๐ž ๐ฌ๐ฉ๐ž๐š๐ค๐ž๐ซ๐ฌ:
โœจOlivier Neyrolles (France)
โœจMax Gutierrez (UK)
โœจSusanne HรคuรŸler (Germany)
โ–ถ๏ธ ndi3.fz-borstel.de

22.05.2025 10:06 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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๐Ÿงต5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

13.05.2025 19:55 โ€” ๐Ÿ‘ 676    ๐Ÿ” 349    ๐Ÿ’ฌ 33    ๐Ÿ“Œ 6
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BREAKING - WHO Director General Shakes Up Agency With Brand New Leadership Team - Health Policy Watch A brand-new WHO leadership team has been announced, including not only a dramatically reduced number ofย  leaders but a major shake-out of longstanding faces

The new WHO team

healthpolicy-watch.news/who-director...

14.05.2025 09:10 โ€” ๐Ÿ‘ 18    ๐Ÿ” 13    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

Amazing story Agnese. Happy to have contributed to it!

A beautiful illustration of a functional split in the Krebs cycle, in a human pathogen, to face nutritional immunity!

Stable isotope tracing tour de force!

13.05.2025 12:51 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Mycobacterium tuberculosis partitions the Krebs cycle to persist under iron starvation In this study, we investigated how iron limitation alters central metabolism in Mycobacterium tuberculosis using metabolomics and stable isotope tracing. Our findings reveal a well-orchestrated metabo...

Proud to share the results of a study that tells us how M. tuberculosis remodels central metabolism in response to iron deficiency.
@agnese75.bsky.social @luizcarvalholab.bsky.social
www.biorxiv.org/content/10.1...

13.05.2025 12:01 โ€” ๐Ÿ‘ 14    ๐Ÿ” 9    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage

Joint work with the Tamulaitienฤ— and Kranzusch labs

www.nature.com/articles/s41...

Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!

30.04.2025 18:44 โ€” ๐Ÿ‘ 88    ๐Ÿ” 43    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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Will climate change lead to more fungal infections? | News | Wellcome Fungi can keep us healthy or cause disease. As climate change drives fungi to adapt, learn how we can harness the benefits and tackle the threats.

Fungi can protect the environment, grow food and even develop new medicines. ๐Ÿ„

But they can also cause disease.

As climate change spreads pathogenic fungi to new places, more people worldwide will be at risk.

Learn more in our explainer โคต๏ธ
wellcome.org/news/will-cl...

24.04.2025 13:10 โ€” ๐Ÿ‘ 73    ๐Ÿ” 28    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2
Cover of new issue of Science Translational Medicine, showing an Ixodes scapularis tick

Cover of new issue of Science Translational Medicine, showing an Ixodes scapularis tick

Identification of a specific, pre-existing beta-lactam antibiotic for treating Lyme disease Borrelia infections. Cool new report from @jutraslab.bsky.social Brandon Jutras & colleagues.
pubmed.ncbi.nlm.nih.gov/40267215/

#MicroSky ๐Ÿฆ ๐Ÿงซ๐Ÿ”ฌ

24.04.2025 12:12 โ€” ๐Ÿ‘ 17    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

๐Ÿ˜ฎ

23.04.2025 20:50 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Arriving in California for @heran.bsky.social GRC on the biology of Mycobacteria! ๐Ÿคฉ๐Ÿ˜ see you all very soon!

07.04.2025 00:45 โ€” ๐Ÿ‘ 10    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium - Nature Microbiology Genomic and functional analyses of healthcare-associated vancomycin-resistant Enterococcus faecium reveal that bacteriocin T8 is enriched in emergent lineages and provides a competitive advantage in v...

Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social

21.03.2025 13:45 โ€” ๐Ÿ‘ 110    ๐Ÿ” 54    ๐Ÿ’ฌ 13    ๐Ÿ“Œ 3
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A polyene macrolide targeting phospholipids in the fungal cell membrane - Nature Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.

Phylogeny-guided natural product discovery reveals new chemical space and a new antifungal effective against drug-resistant strains

๐Ÿงช

www.nature.com/articles/s41...

20.03.2025 08:38 โ€” ๐Ÿ‘ 21    ๐Ÿ” 9    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 2
Cartoon display of the bioenergetic scenario for Huc using either bd-I oxidase or bcc-aa oxidase as pmf-generating unit, driving ATP synthesis by the F1F o-ATP synthase.

Cartoon display of the bioenergetic scenario for Huc using either bd-I oxidase or bcc-aa oxidase as pmf-generating unit, driving ATP synthesis by the F1F o-ATP synthase.

Hydrogenase-driven ATP synthesis from air
www.biorxiv.org/content/10.1...

New work from us where we put the Huc hydrogenase to work to see if it can generate a proton motive force. It can!
cc: @ashleighkropp.bsky.social @rhyswg.bsky.social @greening.bsky.social

19.03.2025 03:21 โ€” ๐Ÿ‘ 27    ๐Ÿ” 12    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
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Discovery of metabolites prevails amid in-source fragmentation - Nature Metabolism Nature Metabolism - Discovery of metabolites prevails amid in-source fragmentation

"There are more real metabolites in mass spectrometry metabolomics, Horatio, than are dreamt of in your philosophy of in-source fragmentation artifacts."

Nice article from @pieterdorrestein.bsky.social and cols.

www.nature.com/articles/s42...

07.03.2025 16:28 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@luizcarvalholab is following 20 prominent accounts