Fabian Spill

ER shaping closes the gap in wound healing Nature Cell Biology - During wound healing, epithelial gaps trigger curvature-dependent ER remodelling. Tubules form at convex cell edges and promote lamellipodial crawling, whereas ER sheets at...

Thanks Craig Blackstone for the news & views @natcellbio.nature.com about our article thats shows how ER shape and mechanics determine the mode of cell migration. Collaboration with Simran, Pradeep and @tamaldastifrh.bsky.social. rdcu.be/eJZWf

🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.

Come do a PhD with us www.crick.ac.uk/careers-stud...

The role of contact guidance and ECM remodelling in cancer invasion: a computational study The extracellular matrix (ECM) is a complex network of fibrous proteins and other macro-molecules that provides crucial mechanical and biochemical cues that regulate cancer cell invasion and tumour pr...

Congrats Margherita on completing her @physicell.bsky.social model investigating the effect of ECM organisation and remodelling and the interplay with chemotaxis on invasion www.biorxiv.org/content/10.1... Great collaboration with @jmetzcar.bsky.social , @mathcancer.bsky.social and Pradeep

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

RESEARCH | ‪@mic-certo.bsky.social‬ C Mauro et al. (U Birmingham)

Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.

overcomes the challenges. Great work by Cass and Gianni, and great collaboration, with Vijay, John, Sean and many others 2/2

The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression A multi-omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machine...

How does the heart age? One challenge to answering this is the lack of available human samples, and another is to integrate different molecular changes. Our paper The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression onlinelibrary.wiley.com/doi/10.1111/... 1/

Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode - Nature Cell Biology Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization ...

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration.
bit.ly/3HFAQ8S

Excited to launch the 1st UK Maths Bio Conference with a freat talk by @tiinaroose.bsky.social on image based modelling of soil

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

lactate regulates immune aggregations in an autoimmune disease nature.com/articles/s42... Study led by great collaborators Mic Certo, Elena Pontarini, Michele Bombardieri and Claudio Mauro 2/2

Lactate was known as a metabolic waste product from glycolysis, but more and more evidence shows it acts as a signaling molecule. Happy to have contributed with former great student @seb-math-bio.bsky.social‬ to the data analysis of a study in
/@natmetabolism.nature.com
showing how 1/

Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds Cellular membranes are dynamic, heterogeneous structures where lipid nanodomains (e.g., lipid rafts) play key roles in signalling, membrane trafficking, and protein function. Single-Molecule Localisat...

Congrats Kylie for publishing her first article from her PhD 'Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds' in ‪@biophysj.bsky.social‬
www.cell.com/biophysj/abs...

Frontiers | A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening

Congrats Margherita for her new paper, where she investigated how cancer spheroids grow in collagen matrices with varying stiffness, implementing varying ECM properties in @physicell.bsky.social Thanks Tom Susan John and Pradeep for the collaboration
www.frontiersin.org/journals/bio...

We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter

Continuum Mechanics in Biology 2025 A three-day workshop addressing the growing interface between continuum mechanics and the life sciences

Meeting at the mathematical modelling/biology interface, in Birmingham in July, organised by @rosemaryjdyson.bsky.social & colleagues.

sites.google.com/view/continu...

🧪🌱🌿

@xiaofu90.bsky.social

@blindmath.bsky.social

@krasimiratsaneva.bsky.social

@kityates.bsky.social

@micromotility.bsky.social

@profruthbaker.bsky.social

@gibin.bsky.social

Excited to announce that registration for UK Maths Bio 2025 is open. We have an exciting list of confirmed speakers and are looking for more exciting talks and posters from the community. Please submit your abstract by 31 March 25.

ukmathbioconference.github.io

Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Compu...

Our new review discusses how mathematical models can help understand the similarities and differences between endothelial and epithelial cells. Thanks
Pradeep, Raul, Maria Jose and
Effie for the collaboration www.cell.com/trends/cell-...

The role of mutants in the spatio-temporal progression of inflammatory bowel disease: three classes of permanent form travelling waves Despite its high prevalence and impact on the lives of those affected, a complete understanding of the cause of inflammatory bowel disease (IBD) is lacking. In this paper, we investigate a novel mecha...

arxiv.org/abs/2501.07205

And congrats @Blaine_VR again, I can't recall I ever had two papers on ArXiv on the same day :) This model is about IBD and identified how mutants and inflammation affect the spread

Eco-evolutionary dynamics of a trait-structured predator-prey model The coupling between evolutionary and ecological changes (eco-evolutionary dynamics) has been shown to be relevant among diverse species, and is also of interest outside of ecology, i.e. in cancer evo...

Congrats Blaine for completing the paper 'Eco-evolutionary dynamics of a trait-structured predator-prey model' which features an analytic analysis of a model with population heterogeneity, transient, and long-term dynamics arxiv.org/abs/2501.07379

@blindmath.bsky.social @krasimiratsaneva.bsky.social @kityates.bsky.social @micromotility.bsky.social @profruthbaker.bsky.social @gibin.bsky.social

Excited to announce the first UK Maths Bio Conference 4-5 September in Birmingham ukmathbioconference.github.io . Registration will open in a few weeks, save the date! Thanks to my amazing co-organisers Valeria, Kyle, Rachel and Phil for all their work planning the conference.

iTARGET: Interpretable Tailored Age Regression for Grouped Epigenetic Traits Accurately predicting chronological age from DNA methylation patterns is crucial for advancing biological age estimation. However, this task is made challenging by Epigenetic Correlation Drift (ECD) a...

Congrats Zipeng on completing his paper iTARGET:Interpretable Tailored Age Regression for Grouped Epigenetic Traits arxiv.org/abs/2501.02401

could be used to identify researchers working on any disease in any region or country Congrats again Rico, great work that started with his master thesis work, thanks to our colleagues Natanya and Sue at BMS and also Sam and Jean-Baptiste for the collaboration 3/3

multiple myeloma in sub-Saharan Africa, and wanted a tool that can be used to identify leading research institutes or hospitals with expertise in myeloma in specific locations. But the network tool Rico developed 2/

Congrats Rico on publishing his article 'Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa'. This paper was motivated to increase global representation in biomedical research. Our collaborators at BMS were specifically interested in t.co/Tj6ShrUoVA 1/

Systems-Mechanobiology - Jobs

Still time to apply for positions in Maths @unibirmingham. We hire on every level, from PhD students to prestigious 125 Anniversary Chair positions, deadline early January. Please spread the word! www.systems-mechanobiology.com/jobs

and inferring how these affect cell functions, such as metabolism or cell migration, in ageing and diseases. But we are open to hearing about your ideas within the broad space of systems models in ageing and diseases edzz.fa.em3.oraclecloud.com/hcmUI/Candid... 2/2