MolinariLab-ER

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social

🚨 Job alert

We’re looking for a communications manager for the LifeArc Rare Respiratory Disease Centre. Deadline for applications 1st August

@lifearc.bsky.social

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

As an angler, getting old, … on your small boat looking down there, where you know pikes are waiting for you ... and then you stop the boat, and it only remains to knot your fishing hook … and you hardly see your fingers.

The expanding repertoire of ESCRT functions in cell biology and disease - Nature This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

The endoplasmic reticulum proteostasis network and bone disease Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...

Targeting proteostasis in multiple myeloma through inhibition of LTK Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX

The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles identi...

ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors.
www.biorxiv.org/content/10.1...

We've just posted a new preprint:

"A GCN1-independent activator of the kinase GCN2"

🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! | institut de Biologie Valrose - iBV 🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! Join the DYNABIO Cluster of Excellence at Université Côte d’Azur and launch your independent research program at the crossroads ...

Excellent opportunity for interdisciplinary scientists. Please repost...

www.linkedin.com/posts/instit...

A1F recognizes 2025 Grant Award Recipients during ATS  - Alpha-1 Foundation On Monday, May 19th, 2025, the Alpha-1 Foundation (A1F) hosted its annual A1F Grants Award Reception at the San Francisco [...]Read More... from A1F recognizes 2025 Grant Award Recipients during ATS

I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".

A1F recognizes 2025 Grant Award Recipients during ATS

alpha1.org/a1f-recogniz...

Testing oysters for the college?

Testing wines for the college?

Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social

What a terrific FASEB ER meeting! Exceptional science and community! ❤️ Plus we got to see sea turtles nesting on the beach and a spaceX rocket launch! Cool!

Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
@faseborg.bsky.social

Melbourne for the ER FASEB. Will check if they remember how to prepare the Manhattan. Pretty sure it will be the best of the day.

… still waiting my day off

Ilaria Fregno from @molinarilab-er.bsky.social is studying the client specific ER-to-Lysosome-Associated Degradation pathways that are engaged by large misfolded proteins (e.g., Serpins polymers, pro-collagen variants and many others) that fail to enter ERAD.

Somatic escape variants of alpha1 antitrypsin. Great presentation by Lily Wu @profmarciniak.bsky.social

Here we are.

N-glycan-dependent protein maturation and quality control in the ER - Nature Reviews Molecular Cell Biology N-glycosylation of secretory pathway proteins in the ER is crucial for their maturation and quality control. Recent insights into the enzymes and chaperones that facilitate N-glycosylation have expand...

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

📣 🥳 🧑‍💻 Our department is hiring:

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark

Deadline June 1st

Thanks for sharing!

mbg.au.dk/en/news-and-...

Dan Hebert Memorial Symposium May 9th, 2025 Room S330/340, Life Sciences Laboratory 240 Thatcher Road University of Massachusetts Amherst Please register by April 18th to help us with planning! Register Here!

For Dan!

sites.google.com/umass.edu/da...

Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Two structurally targeted allosteric regulators of GCase folding promote lysosomal transport of disease-causing variants, reduce ER stress and rescue lysosomal functions. Therapeutic potential for GD, PD, and Dementia with LB.
mdpi.com/3299382 #mdpiijms via @IJMS_MDPI

Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways.

eur02.safelinks.protection.outlook.com?url=https%3A...

NAP Recruitment Event Poster

Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇
www.ntu.edu.sg/science/rese...

🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast!

Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.