MolinariLab-ER

Grazie Stefan!

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Organellophagy receptors display cytoplasmic intrinsically disordered regions (IDRS). The IDRs of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for ER and mitochondria fragmentation that precedes lysosomal clearance of the organelle’s portions.
rdcu.be/eF5DR

Why the foam on Belgian beers lasts so long ETH Zurich researchers have found the holy grail of brewing: the formula for stable beer foam. But it's not just breweries that will benefit from these findings.

An interesting study from the ETH-Zurich

ethz.ch/en/news-and-...

Come join us @science.org. We’re looking for a new editor to look after infectious disease and microbiome submissions.
Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...

From Switzerland to Portugal … and back. 🤔

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux - Nature Cell Biology Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as ...

💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation.
bit.ly/4fLWe99

Thank you Yasin, I have shared this in my Country😀. “We all leave in a … splendid isolation” reminds me a Beatles song …

Grok3, 3 attempts

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social

🚨 Job alert

We’re looking for a communications manager for the LifeArc Rare Respiratory Disease Centre. Deadline for applications 1st August

@lifearc.bsky.social

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

As an angler, getting old, … on your small boat looking down there, where you know pikes are waiting for you ... and then you stop the boat, and it only remains to knot your fishing hook … and you hardly see your fingers.

The expanding repertoire of ESCRT functions in cell biology and disease - Nature This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

The endoplasmic reticulum proteostasis network and bone disease Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...

Targeting proteostasis in multiple myeloma through inhibition of LTK Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX

The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles identi...

ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors.
www.biorxiv.org/content/10.1...

We've just posted a new preprint:

"A GCN1-independent activator of the kinase GCN2"

🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! | institut de Biologie Valrose - iBV 🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! Join the DYNABIO Cluster of Excellence at Université Côte d’Azur and launch your independent research program at the crossroads ...

Excellent opportunity for interdisciplinary scientists. Please repost...

www.linkedin.com/posts/instit...

A1F recognizes 2025 Grant Award Recipients during ATS  - Alpha-1 Foundation On Monday, May 19th, 2025, the Alpha-1 Foundation (A1F) hosted its annual A1F Grants Award Reception at the San Francisco [...]Read More... from A1F recognizes 2025 Grant Award Recipients during ATS

I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".

A1F recognizes 2025 Grant Award Recipients during ATS

alpha1.org/a1f-recogniz...

Testing oysters for the college?

Testing wines for the college?

Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social

What a terrific FASEB ER meeting! Exceptional science and community! ❤️ Plus we got to see sea turtles nesting on the beach and a spaceX rocket launch! Cool!

Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
@faseborg.bsky.social

Melbourne for the ER FASEB. Will check if they remember how to prepare the Manhattan. Pretty sure it will be the best of the day.

… still waiting my day off

Ilaria Fregno from @molinarilab-er.bsky.social is studying the client specific ER-to-Lysosome-Associated Degradation pathways that are engaged by large misfolded proteins (e.g., Serpins polymers, pro-collagen variants and many others) that fail to enter ERAD.

Somatic escape variants of alpha1 antitrypsin. Great presentation by Lily Wu @profmarciniak.bsky.social

Here we are.