Alexandra Boegli

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and viruses in the gastrointestinal tract by a poorly-understood mechanism. This study shows that NLRP6 forms...

Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.

New insights into the activation of the most elusive and (so far) the least understood human inflammasome: NLRP6 is a sensor of endolysosomal damage

Thank you Kateryna!

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage
link.springer.com/article/10.1... @embojournal.org @chmee2.bsky.social @alexandraboegli.bsky.social @brozlab.bsky.social

You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...

Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org

link.springer.com/article/10.1...

NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.

www.embopress.org/doi/full/10....

Beautifully written news and views article by Weber and Rosenstiel about our new NLRP6 story that I was honoured to spear-head 👩‍🔬🔬Perfect for a quick summary!

Happy to announce that our paper is finally out! Thanks to @brozlab.bsky.social and co-authors @elliottbernard.bsky.social @ehartenian.bsky.social 🥳 the NLRP6 inflammasome is activated by sterile- or pathogen-induced endolysosomal damage @embojournal.org

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉

Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!

#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social

🔗 www.nature.com/articles/s42...
🧵1/17

Für Naturwissenschaftliche Fächer haben übrigens doppelt so viele Männer, die John heißen , einen Nobelpreis gekriegt, wie Frauen.

Hypothese: das liegt nicht daran, dass Frauen schlechtere Naturwissenschafter:innen sind als Johns.

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

Dr. Jane Goodall, 1934-2025

An exceptional scientist, and a singular woman in science

#WomeninScience 🐒

www.nytimes.com/2025/10/01/o...

The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.

Congratulations to Urs Jenal for been awarded the Novo Nordisk Foundation grant!

Prof. Urs Jenal ujenal.bsky.social, @biozentrum.unibas.ch, @unibas.ch, @nccr-antiresist.bsky.social shares the grant with Tim Tolker-Nielsen Lab, University of Copenhagen.

#TransformingAntimicrobialResearch #AMR

Photo of Dr Leire Bejarano (left) receiving her award from Prof Margot Thome-Miazza (right)

Huge congratulations to Dr Leire Bejarano, an amazing postdoc from our lab, who received the "Young Researcher in Basic Sciences Award" from the Faculty of Biology & Medicine UNIL

Super proud of you @lbejarano.bsky.social !! 🎉🥳🤩

@fbm-unil.bsky.social @unil.bsky.social

www.unil.ch/news/1749042...

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

📢ONLINE @natgenet.nature.com

📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen.

By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues.

⬇️

www.nature.com/articles/s41...

The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award!

More info: www.unil.ch/news/1749042...

Thank you!

PhDone! 🥳 It has been a pleasure to work in the fantastic @brozlab.bsky.social and celebrate with friends and family! Thanks also to my experts @jelenalab.bsky.social and @veeninglab.com and my president Thierry Roger!

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW

From left to right are Shannon W. Lucid, Margaret Rhea Seddon, Kathryn D. Sullivan, Judith A. Resnik, Anna L. Fisher, and Sally K. Ride. NASA selected all six women as their first female astronaut candidates in January 1978.

Maybe we should honor the women who were real astronauts.

From left to right are Shannon W. Lucid, Margaret Rhea Seddon, Kathryn D. Sullivan, Judith A. Resnik, Anna L. Fisher, and Sally K. Ride. NASA selected all six women as their first female astronaut candidates in January 1978.

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.

Most inflammasome mutations in humans are gain of function, which complicates the question of why we have these molecular machines. @sunnyshinlab.bsky.social et al provide strong evidence that we need inflammasomes to prevent Salmonella infection. A must read! elifesciences.org/articles/90107

Congratulations Sunny and team! Exciting 🥳

Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)

Gigantic birth study paints most detailed picture of pregnancy’s toll on body Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

Biologists have built one of the most detailed pictures ever of the changes that occur in women’s bodies before and after pregnancy, by pooling and studying around 44 million physiological measurements from more than 300,000 births

https://go.nature.com/4236GSV

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

Delighted to see our latest paper selected as “Research Highlight” by @natrevrheumatol.bsky.social !
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky

Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers.

wp.unil.ch/immunobiolog...

Congrats to lab member Elliott for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳 @dib-unil.bsky.social @lifesciswitzerland.bsky.social

The European Federation of Immunological Societies is leading a Women in Immunology 🔬🧪 campaign 🙌

From Feb 11- International Day of Women and Girls in Science, to Mar 8- International Women’s Day

Follow along for their different activities - and thanks for selecting our #gender #equality article 😀

Composite image of women scientists from the Joyce lab over the past 20 years

Happy International Day of Women and Girls in Science!

Its been a privilege to work with these extraordinary scientists in my lab over the years - all making an incredible impact throughout the world 🙌

We must never give up on #equality #diversity & #inclusion 💪

#WomeninScience #GirlsInSTEM 🧪🔬🔭🚀