Thomas Henry

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

02.09.2025 16:22 — 👍 18    🔁 11    💬 0    📌 0

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

19.05.2025 10:46 — 👍 15    🔁 10    💬 1    📌 1

Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8 licenses noncanonical inflammasome activation and pyroptosis during intracellular bacterial infections in human...

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

17.07.2025 12:12 — 👍 19    🔁 10    💬 3    📌 0

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...

03.06.2025 11:26 — 👍 22    🔁 5    💬 2    📌 0

Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...

15.04.2025 18:18 — 👍 5    🔁 3    💬 0    📌 0

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

13.04.2025 15:58 — 👍 50    🔁 44    💬 9    📌 0

Another link between RHO GTPases and inflammasomes. RAC2 GoF variants activate the NLRP3 inflammasome, Congrats to the Boyer group @lauboye.bsky.social!
bsky.app/profile/jem....

11.04.2025 07:17 — 👍 5    🔁 1    💬 1    📌 0

Many phages encode "sponge" proteins that catch immune signaling molecules to block bacterial immunity. Two preprints report a defense system plugged the other way around: the signaling molecule constitutively inhibits the effector, so that sponges trigger effector activity 🤯 what a wild mechanism!

01.04.2025 06:54 — 👍 12    🔁 7    💬 1    📌 0

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

21.03.2025 15:16 — 👍 254    🔁 109    💬 7    📌 15

Portimine A #toxin causes #SkinInflammation through ZAKα-dependent #NLRP1 inflammasome activation

By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues

🗞️https://doi.org/10.1038/s44321-025-00197-4

14.02.2025 20:24 — 👍 4    🔁 3    💬 0    📌 0

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG

11.02.2025 09:57 — 👍 50    🔁 19    💬 6    📌 1