Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.

doi.org/10.1016/j.kint.2025.07.037

#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social

Executive summary of the #KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV)

doi.org/10.1016/j.kint.2025.04.003

#OpenAccess #MedSky #NephSky @kdigo.org

Among hypertensive adults with ambulatory AKI, this #ASNCJASN study found plasma biomarkers reflecting impaired kidney tubule health measured at the time of ambulatory AKI are associated with subsequent non-recovery in kidney function. Read more: kidney.pub/CJASN0910

Le Diabète dans tous ses états Un blog, comme aucun autre, pour découvrir et tout comprendre des mille et une facettes du diabète et de l’obésité.

📚 Déjà 97 articles sur le blog 'Le #diabète dans tous ses états' !
Un contenu rigoureux et accessible.
Physiopathologie, traitements, complications, innovations…
Une ressource unique pour comprendre toutes les facettes de cette maladie complexe
www.le-diabete-dans-tous-ses-etats.precidiab.org

Syndrome d’auto-brasserie : être ivre sans boire une goutte d’alcool
Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang.
www.lemonde.fr/blog/realite... [Rediff]

In this episode, Marie Jeansson explains how the paper's findings suggest that TIE2 activation via angiopoietin-2–binding and TIE2-activating antibody warrants investigation as a therapy in human… Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation

Video Abstract: Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation: youtu.be/oSB3CP5UDPE

@kidneyint.bsky.social

Cancer : la France doit savoir pourquoi elle est surexposée L’étude du « Lancet », qui a placé la France en tête des pays les plus touchés, doit servir de signal d’alarme. Qu’un pays développé ignore l’ensemble des causes d’une incidence singulière du cancer n’est pas acceptable.

Cancer : la France doit savoir pourquoi elle est surexposée

Mineralocorticoid Receptor #MR inhibition in parietal epithelial cells #PEC prevents #FSGS and #crescenticGN. Furthermore, we didn’t find 11βHSD in PECs, suggesting that standard of care could stimulate MR, which is not optimal.
@isgd.bsky.social
doi.org/10.1016/j.ki...

Perturbation of the circadian clock in chronic diseases involving organ fibrosis

This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...

Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of #diabetes and #metabolic syndrome?

Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. Focal segmental glomerulosclerosis (FSGS) is a common histological lesion in adults worldwide. It results from initial podocyte injury, followed by a …

Inhibiting MR protects against glomerular damage by preventing the activation of parietal epithelial cells. A novel mechanism that should impact medical practice.
www.sciencedirect.com/science/arti...
@parcc-inserm.bsky.social @olilen.bsky.social
@upcite.bsky.social @inserm.fr

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation

go.nature.com/3KBRg2W

Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az

Hoover, Hacohen, Davidson @northwellhealth.bsky.social et al. analyze the intrarenal myeloid compartment in four #lupus #nephritis mouse models and 155 humans using single-cell profiling, spatial transcriptomics, and functional studies. rupress.org/jem/article/...

Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...

Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study

Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011

Original article: doi.org/10.1016/j.kint.2025.04.017

#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph

Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline

doi.org/10.1016/j.kint.2025.07.024

#NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social

Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions

doi.org/10.1016/j.kint.2025.07.022

#NephSky #MedSky #AKI #acutekidneyinjury

ICYMI: Chemotaxis as a driver in immune privilege.

O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.

buff.ly/Mwn8t1c

ICYMI:

‼️EXTRAORDINARY WORLD RECORD

Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m !
WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl

BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit)

Also crazy 46.1C Bunji 🇵🇰1469m asl

History is rewritten again

Organ clocks for post-menopausal women taking estrogen or not taking estrogen

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...

Hot day on the French Riviera:
With 37.4C Sete broke its record of July highest temperature on record.

East Asia: The hell is coming.

Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C.

Records will be hundreds (at best)

New COVID Variant NB.1.8.1 'Nimbus' Now Driving 37% of Cases in US: Know These Symptoms A highly transmissible new COVID-19 variant called NB.1.8.1, aka "Nimbus," is spreading in the United States, CDC data show. What to know about symptoms and vaccines.

A highly transmissible new COVID-19 variant is spreading in the U.S.

“Those in high-risk groups should consider getting the vaccine now if they haven’t been vaccinated in the last six months," Prof. Albert Ko told TODAY.
www.today.com/health...

A proof-of-concept study for determining the functional impact of variants of uncertain significance (VUS)!

Muthiah Bose et al. used CRISPR-Select as a tool in the classification of rare VUS in the PALB2-binding domain of BRCA2: buff.ly/oFc574N

ICYMI:
A smooth operator for blood pressure!

Katherine Gallagher & team show the histone demethylase JMJD3 in vascular smooth muscle cells regulates endothelin receptor expression and blood pressure: buff.ly/K8b0CnB

EXTRAORDINARY- MOST EXTREME HEAT WAVE IN WORLD CLIMATIC HISTORY

52.6 in Kuwait,widespread 49/50C in a dozen countries.
44C at 45 latitude in Kazakhstan with night minimums up to 29C

Next days Dozens of thousands of records from Morocco to Japan broken locally with 5/6C margins