Nayan Arora

We need goat yoga for after the #kidneywk run next year

as far as I know the fish oil craze started with bad math over an Icelandic or Greenland study, and has been a cesspit of bad science since then and this finding reminds me of what my mom said:

if it is to good to be true, it is

Agreed - already have some proactive DMI folks on Finerenone - has been safe and lowers proteinuria in my hands

Agreed - seems a little “fishy”

This is like the Rockies winning the World Series….

We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk

jamanetwork.com/journals/jam...

Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk

Simultaneous pub in NEJM

www.nejm.org/doi/full/10....

For finerenone in type 1 DKD I think albuminuria is OK

For Atacicept - this is preliminary data which gets them accelerated FDA approval and a few months of making 💰until the GFR slope analysis comes through?

#KidneyWk

While I agree, here in Australia the drugs will not get funded by the govt without the harder endpoints unless of course the price is okay which of course is not going to happen. It’s exciting to see all these new therapeutics but unless the cost comes down I doubt we will see them in Australia soon

Finerenone has already shown benefit in type 2 DM and the benefit was primarily driven by albuminuria reduction. To me the type 1 diabetes trial was simply a safety trial since there’s no reason to believe the mechanism would be any different so I’m fine with the albuminuria surrogate

@sophia-kidney.bsky.social is working really hard at this conference #kidneywk

Midodrine and octreotide should not be first line therapy for HRS-AKI #kidneywk

@sophia-kidney.bsky.social got shoved into a corner by ASN but well
worth the trek to check out her poster and try out abcKidney #kidneywk

Move on - once it became approved as a surrogate endpoint there is zero incentive for trials to use hard endpoints as primary outcomes. Trials are shorter and more importantly cheaper.

Small trial of lysine chloride in euvolemic patients with heart failure. Median furosemide dose was 80mg. Chloride supplementation reduced plasma volume and improved diuretic response. Interesting but maybe not the population I would use it in? #kidneywk

All of them

#kidneywk has puppies!

We have a new therapy for type 1 diabetes! FINE-ONE with significant proteinuria reduction compared to placebo on a background of RASi with an acceptable safety profile. Where’s the simultaneous pub?? Sglt2 inhibitors are next…#kidneywk

Interim analysis of atacicept (dual BAFF/APRIL inhibitor) shows successful proteinuria reduction vs placebo. Also reduced Gd-IgA1 levels. Adding to the IgA armamentarium. Simultaneous pub 👇🏾 #kidneywk

www.nejm.org/doi/full/10....

New episode of Freely Filtered with @brendonneuen.bsky.social @hswapnil.medsky.social @captainchloride.bsky.social @sophia-kidney.bsky.social and author Muth Vaduganathan discussing the CONVINCE trial

www.nephjc.com/freelyfilter...

With chapters, refs, and pictures

I would accept a UNa

Substantial Discrepancy Between Fluid and Weight Loss During Acute Decompensated Heart Failure Treatment - PubMed Considerable discrepancy between fluid balance and weight loss is common in patients treated for acute decompensated heart failure. Awareness of the limitations inherent to these commonly used metrics...

Good luck getting an accurate weight. Plus are you going to wait 24 hours before dose escalation? And then there’s 👇🏾

pubmed.ncbi.nlm.nih.gov/25595470/

Going to add this to my lecture slides.

Loop Diuretic Dose Intensification versus Adjuvant Thiazide ... : Journal of the American Society of Nephrology g diuretic resistance mechanism could optimize diuretic response. Methods: Patients hospitalized with heart failure and diuretic resistance (6-hour cumulative natriuresis <100 mmol after IV loop di...

Interesting diuretic resistance study. Adunctive thiazides take the lead over loop intensification? Nice discussion on mechanisms of DR, both practical and hypothetical. #nephsky

journals.lww.com/jasn/abstrac...

New blood pressure guidelines recommend skipping alcohol and an earlier start to treatment | CNN The next time you get your blood pressure checked, expect your medical provider to be a little more aggressive about high levels. And if you like a glass of wine with dinner or a cocktail on the weeke...

🤔 I happen to know @jordybc.bsky.social is a scotch aficionado

www.cnn.com/2025/08/14/h...

You can try and avoid chloride but you will suffer the wrath of God

Seems like a bit of a line in the sand. When kidney function worsens > than a certain threshold with decongestion you have to wonder about low flow states, pre-capillary pHTN, etc. Also not clear to me if they assessed GDMT use post d/c and if creatinine went up >40% perhaps less use of these meds?

FF 82 DDAVP up the nose to prevent biopsy bleeding — NephJC Nasal DDAVP to prevent bleeding complications from renal biopsy, the results of two randoized, placebo controlled, trials.

Latest episode of @freelyfiltered.bsky.social is live! This one on the two RCTs of DDAVP to prevent renal biopsy bleeding. We had special guest Vandana Niyyar join us. @medpeedskidneys.bsky.social @captainchloride.bsky.social

www.nephjc.com/freelyfilter...

Remote Measurement of Volume Status in Heart Failure : Journal of the American Society of Nephrology ed with telemedicine services, have failed to improve outcomes. Implantable hemodynamic monitors allow clinicians to obtain meaningful, objective data, with an opportunity for early intervention to im...

Thank you to @asnpublications.bsky.social #JASN for letting us write this. Important topic that's unfortunately devoid of robust data for many of our patients. #nephsky

journals.lww.com/jasn/abstrac...

Ugh you’re right! Fat fingers strike again