@bacteriocins.bsky.social

Day out with the group. First stop at the Museum für Brot und Kunst to see its current exhibition „Winzige Giganten“ (tiny giants) which includes pieces created by our very own PhD student Karo introducing our work on the impact of fertilization on the soil microbiome (project IMPALA)

Impact of Fertilisation on the Bacterial Core Microbiome of Grassland Soils: Abundance in the Field and Growth In Vitro Effects of different organic fertilisation regimes on the bacterial microbiome of grassland soil were analysed by 16S rRNA amplicon sequencing. Different fertilisation regimes led to distinct changes....

As announced a few days ago, Rostand's first paper was accepted in Environmental Microbiology Reports. The paper is now online.
Here is the link: enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....
Huge thanks to the Baden-Württemberg Foundation for funding.

Also today: I realized that we are at 993 followers. C'mon bluesky, get us over the hump to make it 1000.

Also today, we received the proofs of his first paper. Will post the link as soon as the final version is available online

Excellent day. Our very own PhD student Rostand successfully defended his thesis on the impact of organic fertilization on the soil microbiome of grassland ecosystems. Congratulations Rostand, well done.

Keep on keepin‘ on

Finally out: the first paper of our #IMPALA project on the impact of organic fertilization on microbiomes in grassland ecosystems. Here we analyse 16S amplicons. Soon to come #bacteriocin gene clusters in metagenomes of the same samples
academic.oup.com/ismecommun/a...

Great meeting today at Bielefeld University to discuss progress and next steps in WP1 of our EU project #iCulture on production of antimicrobial peptides using biomass of marine macroalgae and the German microbe of the year C. glutamicum

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum N-glycans are highly common sources of nutrition for human colonic-dwelling bacteria. These microbes have evolved a several methods to remove N-glycans from proteins; herein we describe the biochemica...

🚨 New preprint klaxon 🚨
We characterised the structure of a PNGaseA superfamily member from Bifidobacterium bifidum LMG13195 and highlight its preference for N-glycan structures attached to a peptide, rather than to a native or denatured protein 💫 @imibirmingham.bsky.social

So true. And if you want to hear how we try to produce #bacteriocins and other antimicrobial/antiviral peptides using a biotech workhorse organism, come to my talk tomorrow at 11:30h in the Biotechniology for Health Session (Amber 1&2 hall) of #FEMS2025. Or to Poster 395.16P on Thursday.

Ready, set, go for the opening plenary session of #FEMS2025

Bacteriocins.bsky.social will be attending #FEMS2025.
Found out yesterday that my abstract was selected for a talk and poster 😱. All Emails were moved to Spam for some reason 🤯.
Will do my best to give a convincing presentation on recombinant production of #bacteriocins

Had to go through the Editorial Board pinpointing to the publication guidelines. Got the strain in the end.

Once had the same argument with aomw guys from the US. Main result of a paper in Nucleic Acids Research was an E. coli strain to make extracts for SLiCE cloning (similar to Golden Gate Cloning and Gibson Assembly). Strain was commercialized after publication.

How a Biofilm’s Strange Shape Emerges From Cellular Geometry | Quanta Magazine Micro decisions can have macro consequences. A soft matter physicist reveals how interactions within simple cellular collectives can lead to emergent physical traits.

www.quantamagazine.org/how-a-biofil...

#FEMS2025 in Milano and @bacteriocins.bsky.social will be there. Gettin‘ jiggy with it.

Ulmer Münster - Download Free 3D model by LAD BW (@ladbw) Ulmer Münster Ulm (Stadt Ulm) Interaktive Karte aller Modelle Fotos: Martin Schaich 2020 (c) Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart - Ulmer Münster - Download Free 3D model b...

Fantasic digital 3D model of The Ulmer Münster. Highest church tower in Germany and the world (as long as Sagrada Familia in Barcelona remains unfinished)
sketchfab.com/3d-models/ul...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com/articles/s41...

The additional task this year: isolation of bacteria that are able to degrade and utilize polysaccharides of macroalgae for our EU-project #iCULTURE

During steps 1 and 2 we got some really nice isolates with potent antimicrobial activity. And whilst fishing in the dark we also picked up some rally bright, luminescent guys. Back to lab, we are now doing the sequencing part to identify the biosynthetic gene clusters.

Sailing, Sampling, Sequencing - Edition 2025

Question in the recent microbiology exam: What does the abbreviation „LUCA“ stand for?
Answer of one of the students:
„last useless common ancestor“
🤷‍♂️

Bifidobacteria support optimal infant vaccine responses - Nature Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

Once again my old love bifidobacteria prove to be important for proper development of the immune system and may help against reduced vaccine responses indiced by antibiotics
www.nature.com/articles/s41...

Frog-derived synthetic peptides display anti-infective activity against Gram-negative pathogens Synthetic peptides, inspired by the natural defenses of amphibians, demonstrate selective activity against Gram-negative pathogens while sparing the gut microbiota and Gram-positive strains. Rationall...

Great work be the @delafuentelab.bsky.social using Andersonin-D1, an antimicrobial peptide of a frog, as basis to generate potent synthetic peptide antimicrobials by structure-guided design
www.cell.com/trends/biote...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

RIPP family of lasso peptides act by binding to the ribosome and inhibition of protein synthesis www.nature.com/articles/s41...

Just an example of the dedication of women in science: an agar art logo of our iculture-project.eu made by my PhD student Julia

International Day of Women and Girls in Science | United Nations The purpose of the day is to achieve full and equal access to and participation in science for women and girls.

Here’s to all the ladies in science out there and in my lab. You run the show. www.un.org/en/observanc...

I really like reviewing for ASM journals. But since this is going on, I reply to all requests that I am not considering to review again until I ASM is clear about its position on this. Sad.

The system described in 1962 in Aequorea victoria by Osamo Shimomura to start the success of GFP as the most widely used reporter - now put together by synthetic biology to give a set of 20 colours. Amazing.

Things that make the live of a microbiologist easier!