@bacteriocins.bsky.social

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum N-glycans are highly common sources of nutrition for human colonic-dwelling bacteria. These microbes have evolved a several methods to remove N-glycans from proteins; herein we describe the biochemica...

🚨 New preprint klaxon 🚨
We characterised the structure of a PNGaseA superfamily member from Bifidobacterium bifidum LMG13195 and highlight its preference for N-glycan structures attached to a peptide, rather than to a native or denatured protein 💫 @imibirmingham.bsky.social

So true. And if you want to hear how we try to produce #bacteriocins and other antimicrobial/antiviral peptides using a biotech workhorse organism, come to my talk tomorrow at 11:30h in the Biotechniology for Health Session (Amber 1&2 hall) of #FEMS2025. Or to Poster 395.16P on Thursday.

Ready, set, go for the opening plenary session of #FEMS2025

Bacteriocins.bsky.social will be attending #FEMS2025.
Found out yesterday that my abstract was selected for a talk and poster 😱. All Emails were moved to Spam for some reason 🤯.
Will do my best to give a convincing presentation on recombinant production of #bacteriocins

Had to go through the Editorial Board pinpointing to the publication guidelines. Got the strain in the end.

Once had the same argument with aomw guys from the US. Main result of a paper in Nucleic Acids Research was an E. coli strain to make extracts for SLiCE cloning (similar to Golden Gate Cloning and Gibson Assembly). Strain was commercialized after publication.

How a Biofilm’s Strange Shape Emerges From Cellular Geometry | Quanta Magazine Micro decisions can have macro consequences. A soft matter physicist reveals how interactions within simple cellular collectives can lead to emergent physical traits.

www.quantamagazine.org/how-a-biofil...

#FEMS2025 in Milano and @bacteriocins.bsky.social will be there. Gettin‘ jiggy with it.

Ulmer Münster - Download Free 3D model by LAD BW (@ladbw) Ulmer Münster Ulm (Stadt Ulm) Interaktive Karte aller Modelle Fotos: Martin Schaich 2020 (c) Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart - Ulmer Münster - Download Free 3D model b...

Fantasic digital 3D model of The Ulmer Münster. Highest church tower in Germany and the world (as long as Sagrada Familia in Barcelona remains unfinished)
sketchfab.com/3d-models/ul...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com/articles/s41...

The additional task this year: isolation of bacteria that are able to degrade and utilize polysaccharides of macroalgae for our EU-project #iCULTURE

During steps 1 and 2 we got some really nice isolates with potent antimicrobial activity. And whilst fishing in the dark we also picked up some rally bright, luminescent guys. Back to lab, we are now doing the sequencing part to identify the biosynthetic gene clusters.

Sailing, Sampling, Sequencing - Edition 2025

Question in the recent microbiology exam: What does the abbreviation „LUCA“ stand for?
Answer of one of the students:
„last useless common ancestor“
🤷‍♂️

Bifidobacteria support optimal infant vaccine responses - Nature Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

Once again my old love bifidobacteria prove to be important for proper development of the immune system and may help against reduced vaccine responses indiced by antibiotics
www.nature.com/articles/s41...

Frog-derived synthetic peptides display anti-infective activity against Gram-negative pathogens Synthetic peptides, inspired by the natural defenses of amphibians, demonstrate selective activity against Gram-negative pathogens while sparing the gut microbiota and Gram-positive strains. Rationall...

Great work be the @delafuentelab.bsky.social using Andersonin-D1, an antimicrobial peptide of a frog, as basis to generate potent synthetic peptide antimicrobials by structure-guided design
www.cell.com/trends/biote...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

RIPP family of lasso peptides act by binding to the ribosome and inhibition of protein synthesis www.nature.com/articles/s41...

Just an example of the dedication of women in science: an agar art logo of our iculture-project.eu made by my PhD student Julia

International Day of Women and Girls in Science | United Nations The purpose of the day is to achieve full and equal access to and participation in science for women and girls.

Here’s to all the ladies in science out there and in my lab. You run the show. www.un.org/en/observanc...

I really like reviewing for ASM journals. But since this is going on, I reply to all requests that I am not considering to review again until I ASM is clear about its position on this. Sad.

The system described in 1962 in Aequorea victoria by Osamo Shimomura to start the success of GFP as the most widely used reporter - now put together by synthetic biology to give a set of 20 colours. Amazing.

Things that make the live of a microbiologist easier!

The bacteriocins band will be there. We try to get a full gig with three abstracts. See you at at #FEMS2025

Gezielter Eingriff in den Stoffwechsel von Bakterien Antibiotika sollen möglichst toxisch für krankmachende Bakterien sein und gleichzeitig harmlos für die Zellen des menschlichen Körpers. Das HIPS hat nun Wirkstoffkandidaten entwickelt, denen genau das...

#Antibiotika sollen aktiv gegen krankmachende Bakterien sein & dabei den Zellen des menschlichen Körpers nicht schaden. Ein Team des @helmholtzhips.bsky.social stellt nun Wirkstoffkandidaten vor, die den MEP-Weg angreifen, der nur bei Bakterien vorkommt. #AMR
www.helmholtz-hzi.de/media-center...

Excited to join the Bluesky Community 🌍! We - the Helmholtz Institute for One Health - exploring links between human, animal & environmental health to better understand global health challenges like zoonotic diseases and AMR. Follow us for insights & discoveries 🔬
#OneHealth #ScienceCommunication

Metabologenomics-Driven Discovery of Nocardimicins from a Psychrophilic Nocardia sp. Strain A combined strategy of 2D-NMR-metabolomics-driven substructure tracking with genome mining led to the targeted discovery of 10 nocobactin-type lipopeptides (1–10) from the Arctic-derived phychrophillic Nocardia sp. L-016, among which 1–5 are new compounds, named nocardimicins S–W. The phenoxazole moiety in 1–10, featuring unique NMR values and correlations, was used as a probe for tracking nocardimicin analogues. The structures of 1–5 were established based on extensive MS and NMR spectroscopic analyses. The biosynthesis of nocardimicins (1–10) in Nocardia sp. L-016 is proposed to be achieved by the noc biosynthetic gene cluster, which is composed of two sub-gene clusters (I and II) separated by a 228 kb region. Compounds 1–10 showed moderate inhibition against human cancer cell lines of HCT116 and HepG2 with IC50 values in the range of 3.5–10.2 μM. This work provides an effective application of paired-omics technologies in the discovery of new natural products.

Metabologenomics-Driven Discovery of Nocardimicins from a Psychrophilic Nocardia sp. Strain
pubs.acs.org/doi/10.1021/...

Ten species comprise half of the bacteriology literature, leaving most species unstudied Microbiology research has historically focused on a few species of model organisms. Our bibliographic analysis finds extreme bias in the distribution of bacteriology research across species, with half...

Our favorite biotech workhorse C. glutamicum has been named microbe of the year by the VAAM🎉. But it is not amongst the 50 most studied bacteria in literature 🥺. Still a lot of work to be done.
www.biorxiv.org/content/10.1...

It’s official: The Microbiology Society is on Bluesky!

Interesting study by the Kovaćs group showing that production of surfactin, a non-ribosomal lipopeptide supresses production of the bacteriocin subtilosin A by both autocrine and paracrine mechanisms. Looks like counterregulation of two antimicrobial peptides

Great work by the Drescher group showing that various Gram pos and neg bacteria sense peptidoglycan as a danger signal and protect themselves by producing ECM and formation of biofilms. The involves c-di-GMP signalling.
But what is the receptor? A bacterial TLR?