J.-F. Cavalier

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1

Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.

Now out in Trends In Microbiology! Iron-sulfur proteins in mycobacteria: Master regulators of physiology and pathogenesis. Kudos to Valentin Berdal and Wassim Daher. Fantastic exchanges and discussions with leaders in the field: Béatrice Py, Sandrine Ollagnier de Choudens
lnkd.in/dKGd2P8S

Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…

🚨 New review from our group!
PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases.
@ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social

www.sciencedirect.com/science/arti...

Kien Lam UNG is a recipient of the 2025 ATIP-Avenir program - IPBS-Toulouse Kien Lam UNG obtained his PhD from the University of Montpellier, where he worked on[…]

🎉🎉🎉 Big congrats to Kien Lam UNG, recipient of the 2025 #ATIP-Avenir award!
From decoding antibiotic resistance in M. abscessus to revealing plant hormone transporters in Nature, he is now launching a bold project on how sugar tweaks shape host–pathogen battles. Sweet science! 👏👏👏

shorturl.at/TJiHg

The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae Gram-negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high-priority pathogens. One strategy that has increased is the u...

Today is a great day!
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...

👉 onlinelibrary.wiley.com/doi/10.1002/...

Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...

It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊

pubs.acs.org/doi/10.1021/...

⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org

pubs.rsc.org/en/content/a...

Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria Despite the availability of antibiotics, tuberculosis (TB), caused by Mycobacterium tuberculosis, was once again declared the world's leading cause of…

Happy to share our new article in Current Research in Microbial Sciences @canaanlab.bsky.social
Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb.

www.sciencedirect.com/science/arti...

Chemical strategies for targeting lipid pathways in bacterial pathogens Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio
www.sciencedirect.com/science/arti...

With Trump review, a Harvard infectious disease researcher stands to lose it all "This looks bad"’ A Harvard infectious disease researcher is targeted in President Trump’s review

"This looks bad"’ A Harvard infectious disease researcher is targeted in President Trump’s review

Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation | mSystems Tuberculosis is a devastating human disease that kills over 1.2 million people a year. This disease is caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb). Mtb excels at surviving in the...

New paper from the Beatty Lab! 👇
Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation | mSystems journals.asm.org/doi/10.1128/...

£3.4m awarded to study effectiveness of antibiotics against TB Crick Group Leader Max Gutierrez has received a £3.4 million Wellcome Discovery Award to investigate how differences in immune cells impact the effectiveness of antibiotics against tuberculosis.

Congratulations to group leader @maxgg.bsky.social, who received a £3.4m @wellcometrust.bsky.social Discovery Award to study the effectiveness of antibiotics against tuberculosis.

www.crick.ac.uk/news/2025-04...

Great collaborative work @lkremer1.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social @audebertstephane.bsky.social and more!

Thrilled to share the last work from the lab! Generating a mycobacterial strain lacking all T7SS and studying the contribution of ESX-3 and ESX-4 in M. abscessus pathogenesis. Great collab with E Tocheva and JL Herrmann.
rdcu.be/d8uHH

Watch out for those bastard professors

Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of:
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8

🔊 JOB ALERT!

L'IPBS Toulouse recrute un personnel technique pour rejoindre l'équipe émergente "Biochimie et Biologie Structurale des Protéines Membranaires" dirigée par le Dr Kien Lam UNG @unglam.bsky.social à partir de février 2025.

Voir l'offre et candidater :

emploi.cnrs.fr/Offres/CDD/U...

Relaxation time and Christmas lunch at @canaanlab.bsky.social

FEBS Press Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...

After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more

febs.onlinelibrary.wiley.com/doi/10.1002/...

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social

jbiomedsci.biomedcentral.com/articles/10....

FEBS Press Genetic engineering and quantitative fluorescence imaging are key approaches in modern biology research. In this research letter, we report the development and the validation of a new subset of Esche...

🚀💥🔥Happy to Share that Our Latest Story is Now Published in FEBS Letters! 💙💎💡

Have a look & find out about the new subset of Mycobacterial CRISPRi vectors we optimised for our community! 🦠🔦🔬💊

@cnrs.bsky.social
@addgene.bsky.social

👇👇👇

febs.onlinelibrary.wiley.com/doi/full/10....

An mRNA Display Approach for Covalent Targeting of a Staphylococcus aureus Virulence Factor Staphylococcus aureus ( S. aureus ) is an opportunistic human pathogen that causes over one million deaths around the world each year. We recently identified a family of serine hydrolases termed fluor...

A new preprint from Matthew Bogyo. They developed and screened cyclic peptide libraries using mRNA display with a genetically encoded oxadiazolone (Ox) electrophile that was previously shown to potently and covalently inhibit multiple Fph enzymes in S. aureus.

www.biorxiv.org/content/10.1...

I made a Starter Pack for the Myco & TB community.
Hope to find more good friends here on Bluesky to keep in touch about mycobacterial infections. Please join and repost!

go.bsky.app/3nwpcVV