🔋Mitochondria Mechanic🔬

Figure from the textbook Bioenergetics 4th edition by Nicholls & Ferguson

Some more fun #mitochondria science for Friday, from Bioenergetics 4th edition by Nicholls & Ferguson. Mitochondrial charge, respiration, and oxidant production relationships: 🧪

Excellent review on mitochondria and inflammation exploring how endosymbiosis may explain some things. 🧪

www.nature.com/articles/s41...

A mitochondrial origin for inherited diabetes mellitus 🧪

www.nature.com/articles/s41...

“The theory of endosymbiosis provided us with a huge insight into the evolution of eukaryotic life; without this unlikely random event, we as a species would not have evolved to consider it.”

Excellent review on mitochondria and inflammation exploring how endosymbiosis may explain some things. 🧪

www.nature.com/articles/s41...

Figure from the textbook Bioenergetics 4th edition by Nicholls & Ferguson

Some more fun #mitochondria science for Friday, from Bioenergetics 4th edition by Nicholls & Ferguson. Mitochondrial charge, respiration, and oxidant production relationships: 🧪

Image of a textbook figure and legend describing protein import to mitochondria.

How do proteins get into mitochondria? Another graphic from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪

That phrase is definitely a bit outdated, but I think it does more good than harm! Always a good thing to have young scientists interested in the coolest organelle ever

Image of a textbook figure and legend describing protein import to mitochondria.

How do proteins get into mitochondria? Another graphic from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪

Image of a textbook figure outlining metabolic control analysis for isolated bioenergetic organelles.

Studying mitochondria in isolation has revealed complex bioenergetic relationships that are useful for understanding physiology in general. More good stuff from Bioenergetics 4th edition by Nicholls & Ferguson 🧪

"We breathe at the molecular level when mitochondria in our cells consume oxygen to extract energy from nutrients." Great first sentence of an abstract from this paper:

www.science.org/doi/10.1126/...

Hey. The fragmentation of the social media landscape has been hard on indie #scicomm 🧪 projects

So if you'd like to follow a podcast that's enthusiastic about #linguistics, could you check out @lingthusiasm.bsky.social?

And if you think your followers might like to, could you give this a repost?

Image of a textbook figure outlining metabolic control analysis for isolated bioenergetic organelles.

Studying mitochondria in isolation has revealed complex bioenergetic relationships that are useful for understanding physiology in general. More good stuff from Bioenergetics 4th edition by Nicholls & Ferguson 🧪

Mitochondria are the powerhouse of the cell

Image of a figure from a Bioenergetics textbook showing how mitochondria move in cells.

Mitochondria move around in cells 🔋🏎️ Heres another nice diagram from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪

Photo of a textbook figure showing electrochemical gradient composition in bioenergetic membranes.

Mitochondria use an electro⚡chemical🧪 proton gradient. It's usually mostly electric potential, but different circumstances can increase the contribution of diffusion potential. A deep cut from Bioenergetics 4th edition by Nicholls & Ferguson 🔋

Delta p = the entire potential
Delta psi = electric potential
Delta pH = diffusion potential

Delta p = delta psi + delta pH

Photo of a textbook figure showing electrochemical gradient composition in bioenergetic membranes.

Mitochondria use an electro⚡chemical🧪 proton gradient. It's usually mostly electric potential, but different circumstances can increase the contribution of diffusion potential. A deep cut from Bioenergetics 4th edition by Nicholls & Ferguson 🔋

Image from a figure in the textbook Bioenergetics 4th edition by Nicholls & Ferguson. It shows how mitochondrial function is similar to an electric circuit.

Mitochondria are little circuits in our cells. 🔌⚡💡🔋 Helpful analogy for interpreting many bioenergetics experiments. Another great figure from Bioenergetics 4th edition by Nicholls & Ferguson. 🧪

Resistance Exercise Training in Individuals With and Without Cardiovascular Disease: 2023 Update

Lift some weights! 💪 It doesn't take too much to protect your heart 🫀 and health 🧪

New @American_Heart statement:

professional.heart.org/en/science-n...

SARS-CoV-2 can damage mitochondrion in heart, other organs, study finds

"systemic immune and inflammatory responses may lead to more severe illness in some patients"
SARS-CoV-2 can damage mitochondrion in heart, other organs, study finds.

Would B12 help? B12 would help.
#helpmechangethefuture
CDC case# 1232781-B4W6H4

www.cidrap.umn.edu/covid-19/sar...

Organ aging signatures in the plasma proteome track health and disease - Nature Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and ...

What is human aging? We still don't really know, but our organs might predict healthy versus unhealthy aging. 🧪

www.nature.com/articles/s41...

Mitochondria, inflammation, and cardiovascular disease each influence one another. Interesting read: 🧪

journals.physiology.org/doi/abs/10.1...

Mitophagy in human health, ageing and disease - Nature Metabolism This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.

Replacing damaged mitochondria with new ones could be important for many human diseases; high-quality causal studies are needed to start translating this growing evidence. 🧪

www.nature.com/articles/s42...

Mitochondrial proton leak in cardiac aging Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the fundamental mechanisms of physiologic aging are poorly un...

Mitochondrial power and cardiac aging:🔋🫀🧪 Great review article on one of my favorite broad topics:

www.ncbi.nlm.nih.gov/pmc/articles...

‘Politicians don’t understand science’: advisers give evidence at UK COVID inquiry Patrick Vallance, Chris Witty and others reflect on advising the UK government during the ongoing investigation into the country’s pandemic response. Patrick Vallance, Chris Witty and others reflect...

"Politicians don't understand science"

... say the key science advisers during an inquiry that was set up to investigate how prepared the United Kingdom was for the COVID-19 pandemic.

I say "duh!"
🧪

www.nature.com/articles/d41...

Mitochondrial proton leak in cardiac aging Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the fundamental mechanisms of physiologic aging are poorly un...

Mitochondrial power and cardiac aging:🔋🫀🧪 Great review article on one of my favorite broad topics:

www.ncbi.nlm.nih.gov/pmc/articles...

Muscle mitochondrial bioenergetic capacities is associated with multimorbidity burden in older adult... medRxiv - The Preprint Server for Health Sciences

Can looking at muscle mitochondria predict how sick older people may be? Looks like yes. Mitochondrial decline is likely both a cause and a consequence of biological aging. 🧪 unreviewed preprint:

www.medrxiv.org/content/10.1...

i’m a metabolism scientist at city of hope who can’t stop thinking about NAD coenzymes

have some exciting results on a rare disease as well

what interests you?