Leo Scheller

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

Watch out, one of the best in the field! 😀

Molecular basis for anti-jumbo phage immunity by AVAST Type 5 Jumbo phages protect their genomes from DNA-sensing bacterial defense systems by enclosing them within vesicles and nucleus-like compartments. Very little is known about defense systems specialized to...

We (meaning Aswin and Stan www.biorxiv.org/content/10.1...) found this jumbophage protein homologue of PhiKZ_124 that activates Avast5 and we solved a 2.1A cryoEM structure of but we have no idea what it does. Let me know it you got some idea. www.rcsb.org/structure/9RP3

My highest recommendation! Working with Martin is the ideal entry point into protein design.

Humanized Caffeine-Inducible Systems for Controlling Cellular Functions https://www.biorxiv.org/content/10.1101/2025.06.13.659463v1

Caffeine-regulated molecular switches for functional control of CAR T cells in vivo https://www.biorxiv.org/content/10.1101/2025.06.13.659487v1

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️

Adapting ProteinMPNN for antibody design without retraining The neural network ProteinMPNN designs protein sequences capable of folding into predefined tertiary structures and quaternary assemblies. It has become widely used due to its high success rates when ...

"Adapting ProteinMPNN for antibody design without retraining"

Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted

a cat is sitting in front of a laptop computer asking for advice ALT: a cat is sitting in front of a laptop computer asking for advice

Hi everyone! I’m a #NewPI just starting my lab and would love to hear your advice on lab management and building the lab culture. Any tips, lessons learned, or resources you’ve found helpful are very welcome! Feel free to reply, message me, or email me at rcastellsg(at)cnio.es
thanks a lot!! 🤗

Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social.
I'm so excited about this!
www.biorxiv.org/content/10.1...

Modular Engineering of Thermo-Responsive Allosteric Proteins Thermogenetics enables non-invasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membra...

www.biorxiv.org/content/10.1...

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.

Programmable protein stabilization with language model-derived peptide guides - Nature Communications Dysregulated protein degradation drives diseases like cancer. Here, authors use protein language models to design target-binding peptides, which are subsequently attached to the catalytic domain of th...

Programmable protein stabilization with language model-derived peptide guides

www.nature.com/articles/s41...

You’ve heard of vibe coding—meet vibe protein design. Click, launch, and watch the binders roll in. That’s what we're unveiling with @ariaxbio.bsky.social today.

AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵
🌐 afesm.foldseek.com
📄 www.biorxiv.org/content/10.1...

Baker lab PyMOL config 👇

Thank you, Lennart! I'm very excited to join the newly founded Carl Zeiss Center for Synthetic Genomics and KIT with your lab nextdoor! Exciting times ahead!

Work With Us The LIT welcomes individuals from all life paths and academic backgrounds. If you are passionate about science we could be the perfect home for you.

I’m looking for a BTA and a Postdoc to help set up the Structural Biochemistry group at the Leibniz Institute for Immunotherapy (LIT) in Regensburg 😀.

We apply synthetic biology and protein design to address key challenges in immunotherapy.
lit.eu/work-with-us/
#SynBio #ProteinDesign #Immunotherapy

Academic Europe - Postdoctoral scientist (m/f/d)

Job - Alert 🌱

‼️ POSTDOCTORAL SCIENTIST (M/F/D)

Deadline: 2025-04-06
Location: Germany, Regensburg, Bayern

www.academiceurope.com/job/?id=7176

#hiring #Immunotherapy #Postdoc #LIT #syntheticbiology #proteindesign

new blogpost on protein binder design blog.booleanbiotech.com/protein-bind...

Hello bluesky

Hats off to all our american colleagues out there protesting in the streets today, scientific progress is the only way to a better future and no government should stand in the way of that ✊🏼

@synbio4allafrica.bsky.social #PlantSynBio education project will enable local students to sequence a native plant species and gain hands-on research and data analysis skills. They’ve secured ~76% of their microgrant.
Now they need our help to cross the finish line: experiment.com/projects/exp...

Same 😀 🙌

Sure, let’s chat 😀

Leibniz Institute for Immunotherapy The LIT develops innovative therapies for the treatment of cancer, autoimmunity, and chronic inflammation by reprogramming immune cells.

I’m happy to share that I will join the LIT in Regensburg (lit.eu) as a Group Leader in Structural Biochemistry in May. We will combine synthetic biology and protein design to develop synthetic receptors and protein therapeutics to improve immunotherapy. Job openings will be available soon!

FAMPNN architecture

All-atom fixed backbone protein sequence design with FAMPNN

@richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social

www.biorxiv.org/content/10.1...

De novo design of transmembrane fluorescence-activating proteins pubmed.ncbi.nlm.nih.gov/39972138/ #cryoEM

Abundant clock proteins point to missing molecular regulation in the plant circadian clock | Molecular Systems Biology imageimage~100,000 copies of plant circadian clock proteins per cell were predicted from RNA levels and included in detailed models. Protein levels and DNA-binding were validated, using NanoLUC report...

Abundant clock proteins point to missing regulation in the plant circadian clock www.embopress.org/doi/full/10.... first experimental determination of the abundance of transcription factors in Plants and for the circadian clock. It was such a challenge but finally out after peer review !!!