Jacob Kimmel

we're entering a new phase @newlimitbio.bsky.social & beginning to progress our first medicines for aging & disease.

now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life.

it's a privilege to build this future with generational partners.

health is both the most valuable commodity & a Jevons good.

the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.

close to heaven, could only be better with tartine bread

Introducing Ai2 Paper Finder | Ai2 Ai2 Paper Finder is an LLM-powered literature search system that mimics the iterative paper-finding process.

AI2's paper finder is one of the best improvements to my research workflow in years

highly recommended:

Noam is a hero. It’s a shame there are no good books about him. “Man who fed the world” doesn’t do him justice.

YouTube video by NewLimit NewLimit Progress Update 2025

each year @newlimitbio.bsky.social, we share an update on our progress with the public

this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon.

watch here: m.youtube.com/watch?v=HR0-...

January // February 2025 Progress Update Therapeutic beginnings

early winter @newlimitbio.bsky.social:

- +3 TF sets with efficacy in animal disease models
- +3 TF sets that restore youthful function in old T cells
- 20X increase in humanized liver screening throughput
- 2X better in silico reprogramming than the best baseline

details: bit.ly/4iuBvqC

cognitive drills are substantially underrated in molecular biology & genomics

half of creativity is having the ingredients for invention top of mind

building a Borgesian mental library of enzymes & reactions pays dividends

thanks for sharing, reached out :)

2024 Year in Review Restoring youthful function

2024 @newlimitbio.bsky.social:

- 10X Engine throughput
- Discovered TF sets that reprogram cell age & preserve type
- Restored youthful function in a disease model with drug-like reprogramming

we demonstrated that reprogramming medicines are possible

2025: we start to develop them

bit.ly/4h7rrD3

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation - Nature Genetics Borzoi adapts the Enformer sequence-to-expression model to directly predict RNA-seq coverage, enabling the in-silico analysis of variant effects across multiple layers of gene regulation.

Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction.

www.nature.com/articles/s41... 1/

this is gorgeous! any trick to spotting these events?

would love to meet while you’re in town

for hotels, South SF is probably a good 80/20. mostly oriented toward biotech travelers & ~15’ from downtown.

the Sound Life Cohort from Allen Immunology has 100+ patients for PBMCs.

Unfortunately I don’t think there are any multi-tissue unified efforts at that scale yet, so the best data available today might need to integrate across studies.

zenodo wrapped: which supplemental methods did you most rely upon 🙂

excited to dig into this, congratulations to the team 🎉

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

obesity installs an epigenetic memory that persists even after weight loss

this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient

imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time

we remodeled also @newlimitbio.bsky.social hq.

we stole design ideas from bell labs & skunk works, then added glass everywhere to mimic the future we're trying to build.

we're all excited for the discoveries to come in our new space.

we've previously discovered TF sets that reverse T cell age using a phenotypic approach. for each TF set, we ask if it makes old T cells "look" younger based on gene expression.

last month, we developed our 1st functional screening system that directly measures the impact of 100s of TF sets at once

discovering TF sets that reverse cell age is only the first step to making a medicine. next, we'll need to formulate these TF sets into drugs.

@newlimitbio.bsky.social is leveraging LNP-mRNA technology to achieve this, similar to the COVID vaccines.

our Metabolism team developed 2 gold-standard pre-clinical models for hepatocytes.

consistent with our previous results, old hepatocytes are more susceptible to damage than young in both settings.

We've ported our Engine technology to human hepatocytes and received our first in vivo screening results

to our knowledge, these are the first in vivo screening data for human hepatocytes & the first 70 reprogramming sets tested to date. already we're seeing promising signals.

September // October 2024 Progress Update In chimerico reprogramming

early autumn @newlimitbio.bsky.social:

- 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system
- +2779 TF sets tested in T cells
- +51 sets that reverse phenotypic age in T cells
- 5 → 7 functional assays for hepatocyte age
- 0 → 80% efficiency LNP-mRNA delivery

bit.ly/4g0NKJV

jacob let’s be honest we all know you mostly use fruits

July-August 2023 Progress Update Recursive record setting

late summer @newlimit

- world's largest partial reprogramming screen (again)
- 3x'd speed of sequencing turn-around
- 5x'd reprog factor library size
- built our first integrated reprog corpus for model training
- team += 3

blog.newlimit.com/p/july-augus...