Seth Bannon

The non-monarchies that put their sitting leaders on money:

Iraq
Syria
Turkmenistan
Ghana
Uganda
Libya
Turkey
Kenya
Tanzania
Malawi
Zambia
Guinea
Dominican Republic
Bangladesh
Vietnam
Indonesia
Botswana
Tunisia
North Vietnam

The best and the brightest from around the world studying at American universities is great for America.

Our universities are magnets for the world's top talent. They draw them into America, where they often stay, build incredible companies, open great labs, become Americans!

When you create a maximally truth seeking AI and it conflicts with your worldview, you can do one of two things...

Ambition without mission is a sprint to nowhere.

IT'S TIME TO BUILD

Big things. Bold things. Like replacing your local car dealership’s receptionist with ChatGPT apparently.

Fifty Years Fifty Years – We back the indispensable using technology to solve the world's biggest problems.

No program or course has given me more transformative insights into #company building and personal development than the 5050 UK program (www.fiftyyears.com).

Each week, the @FiftyYears team mentors us on how to develop the traits of great founders…

Thread.

www.linkedin.com/posts/bjorno...

The best possible future is one in which the US and China build the future together as allies.

www.politico.com/news/2025/05...

Convening a dozen federal agencies. To tackle healthcare? AI policy? Economic growth?

No. To go after Harvard.

80% of Chinese STEM grads stay in the US. They build American companies, advance American science, power the American economy.

The ones that go back home PAID to be influenced by America. They often return with a love of the USA and a deep connection to America.

Harvard’s refusal to bow to authoritarian pressure is goddamn impressive.

A great strength of America is that the best and brightest from around the world clamor to come here. To innovate and build on our shores. Why are we fighting to change that?

Israel and the United States causing and allowing the mass starvation of women and children will only radicalize another generation. It's the surest way to prolong the cycle of violence. It makes Israel less safe and is unfathomably cruel to the people of Gaza.

It’s fair to ask why everyone in the US gets due process before deportation, including those here illegally.

The answer is simple: without due process for everyone, the government could deport citizens, because due process is how citizens prove they are citizens.

Metformin might be the most studied longevity drug that’s already FDA approved. Improves insulin sensitivity, fitness, and immune function in healthy adults.

elicit.com/review/22d92...

The great strength of America is that it attracts the best and the brightest from around the world. For the first time in modern history, America is facing a brain drain. This is how you give up the future.

www.nature.com/articles/d41...

If you wanted to absolutely gut American manufacturing capabilities, you would tax manufacturing inputs to drive up the cost of manufacturing things in the US, while taxing imported finished products at a lower rate, to advantage companies that manufacture overseas.

None of those are reasons we need to test in animals. They're reasons we needed to test in animals. We're on the cusp of having better modeling and non-animal systems to get this data.

FDA Announces Plan to Phase Out Animal Testing Requirement for Monoclonal Antibodies and Other Drugs FDA Announces Plan to Phase Out Animal Testing Requirement for Monoclonal Antibodies and Other Drugs

10/ The announcement

www.fda.gov/news-events/...

9/ We’re entering an era where the slowest part of medicine won’t be the science -- it’ll be the willingness of institutions to evolve.

Good to see the FDA modernizing like this!

8/ The old dogma: “We have to test it in animals.”

The new ethos: “We should test it in systems that work.”

That means leveraging AI, synthetic biology, and human-relevant models.

7/ The downstream effect?

💊 Cheaper drugs
🐭 Fewer animals used
⚡️ Faster approvals
🧠 More accurate models of human biology

6/ This isn’t just a policy update. It’s a signal.

The regulatory state is catching up to the science.

And that opens the door to faster, safer, and more ethical drug development.

5/ The FDA just released new draft guidance:

🧪 Removing routine animal tests for mAbs targeting non-human antigens
🧠 Encouraging case-by-case waivers for other biologics
👀 Eyeing “stepwise” expansion of non-animal approaches

4/ The focus now is monoclonal antibodies (mAbs), the engine behind many of the most important therapies in cancer, autoimmune disease, and infectious disease.

3/ This shift stems from the 2022 FDA Modernization Act, which for the first time allows non-animal alternatives like computational models, organ-on-a-chip systems, and advanced in vitro assays.

2/ For decades, animal testing has been a regulatory bottleneck in drug development.

Not always predictive. Not always necessary. Very expensive. Often cruel.

We have better tools now. The FDA is now acknowledging that.

1/ GOODBYE ANIMAL TESTING

Big news from the FDA: They're starting to phase out animal testing requirements for monoclonal antibodies and other biologics.

HUGE DEAL for science, ethics, and innovation.

So much potential is lost to shallow but lucrative pursuits.

So next time you hear "trade deficit," don't picture a country getting scammed. Picture a wealthy nation swiping its card because it can.