This is figure 2, which shows the effect of COVID-19 and the pandemic on brain ageing.
Rates of brain ageing accelerated during the COVID-19 pandemic, even among those who did not get infected with SARS-CoV-2, suggests a study of nearly 1,000 UK adults published in Nature Communications. go.nature.com/4lZA5Xf #medsky 🧪
22.07.2025 22:18 — 👍 32 🔁 13 💬 2 📌 2
Translating brain anatomy and neurodegenerative disease from mouse to human through latent gene expression space
The mouse model is by far the most widely used animal model in preclinical neuroscience, but translating findings to humans suffers from the lack of a formal framework establishing the correspondence between the mouse and the human brain. In this study, we build on the concept of common brain space, and on previous work embedding gene expression profiles, to bring the two species into alignment for comparative analysis. Using a variational autoencoder (VAE) combined with a latent classifier, we create a latent space that strikes a balance between abstract features related to reconstruction and features pertaining to regional segregation. This approach demonstrates improved cross-species homology and within-species locality compared to existing comparative models. In addition, we show that brain alterations in mouse disease models can be translated to humans, predicting patterns of brain changes in Alzheimer's and Parkinson's diseases. The flexibility and scalability of this approach offer a promising framework to bridge between more animal models, comparing quantitative imaging modalities, and disease phenotypes. This in turn will help advance our understanding of species similarities and differences, enhancing both fundamental translational neuroscience and disease modelling. ### Competing Interest Statement The authors have declared no competing interest.
Preprint alert: www.biorxiv.org/content/10.1...
02.04.2025 08:24 — 👍 3 🔁 3 💬 0 📌 0
Imaging Neuroscience new-paper posts from 2023. At the end of December we'll post the much bigger 2024 montage (even Rocky had a montage).
06.12.2024 06:20 — 👍 61 🔁 15 💬 1 📌 2
New paper in Imaging Neuroscience by Christoph Arthofer, Frederik J. Lange, et al:
Internally consistent and fully unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM
doi.org/10.1162/imag...
02.12.2024 13:02 — 👍 24 🔁 6 💬 0 📌 0
First post!
New preprint led by @josepemanzano.bsky.social on amortised simulation-based inference #SBI to map orientation #uncertainty and perform brain #tractography. Great collaboration with @jakhmack.bsky.social, @ppjgoncalves.bsky.social, @deismic.bsky.social.
21.11.2024 14:06 — 👍 18 🔁 8 💬 0 📌 1
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Medical-image Analysis and Statistical Interpretation Lab (Director). Vanderbilt University (Professor). All opinions are my own.
Also X: @MASI_Lab
https://my.vanderbilt.edu/masi/
M&C Lab @ Vanderbilt University Medical Center
(PI: Kurt Schilling)
https://microstructure-connectivity-lab.com/
Neuroscientist and connectome researcher. Human & chimpanzee brain connectivity / microstructure using diffusion MRI. Learning & brain plasticity @ MPI CBS, Leipzig
We develop and deploy neuroimaging and related technologies to solve big challenges in basic neuroscience and brain health.
@imaging_cancer MR Core Lab lead, imaging scientist, mum, treehugger, ex-gymnast #ClinicalTranslation #MRISustainability
Assistant Professor at Instituto Superior Técnico, Universidade de Lisboa, Portugal
Science journalist covering all fields. Formerly an editor at New Scientist and Nature. Particular fan of health, mushrooms, amphibians, marine life and nature 🧪🐸 🍄
Selection of articles here: https://www.newscientist.com/author/chris-simms/
European Research Council, set up by the EU, funds top researchers of any nationality, helping them pursue great ideas at the frontiers of knowledge. #HorizonEU
I usually do diffusion MRI stuff.
UKRI Future Leaders Fellow,
Professor of Computational Neurology, Newcastle University.
Working on epilepsy, surgery, neuroimaging, EEG, nonlinear dynamics, complex networks.
www.cnnp-lab.com
A world-class university research partnership, pooling the collective excellence of universities in the Midlands.
The Cognition and Brain Circuitry Lab at OSU, focusing on brain connectivity, function, and behavior, with a special focus on visual perception and attention. Thoughts and opinions are our own.
Lab website: https://www.davidosher.com/index.html
www.sysneuro.org
Melbourne, Australia
Equation loving Magnetic Resonance Imaging (MRI) scientist and pre-developer at Siemens Healthineers.
#MRI Physicist @UWHealth.bsky.social
Faculty @UWiscRadiology.bsky.social
#bassist, #motorbike rider, and #generalAviation pilot
samuel.hurley@pm.me
www.paradime.net
www.qmri.net
Never go against a Sicilian when death is on the line!
