Abraham Acevedo

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...

🚨 New #ALS #MND publication from our lab (co-lead @drchayts.bsky.social), in collaboration with Bernát Nógrádi and colleagues from Hungary and Sonia Alonso-Martin and colleagues from Spain, just published in @natcomms.nature.com -> rdcu.be/eyNIs

'There's an arrogance to the way they move around the city': is it time for digital nomads like me to leave Lisbon? Like so many others, I moved from London to Portugal’s capital for the sun, lifestyle – and the tax break. But as tensions rise with struggling locals, many of us are beginning to wonder whether we’re doing more harm than good …

'There's an arrogance to the way they move around the city': is it time for digital nomads like me to leave Lisbon?

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

Nature research paper: Imidazole propionate is a driver and therapeutic target in atherosclerosis

go.nature.com/44Te0SA

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

“Sleep, like ageing, may be a inescapable consequence of an aerobic metabolism” 🤔

www.nature.com/articles/s41...

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

Job alert!! Postdoctoral position (3 years) available soon in our lab in Tenerife to study immunity and cell signalling in neurodegeneration using mouse models. If you are interested, please email me with a CV and motivation letter: aacevedolab@gmail.com

This is a great piece on failure in academia. "“Has the author considered submitting to a smaller, more specialized journal?” Yes, I have." 😀

Thrilled to share that we've got a #CaixaResearch
Grant! Super excited to start working w/amazing collaborators @acevedolab.bsky.social (#FIISC) and @cabimer.bsky.social colleague @daniel-rico-bio.bsky.social @csic.es. Stay tuned, we'll all be recruiting postdocs soon! @unisevilla.bsky.social

All babies in England to get DNA test to assess risk of diseases within 10 years Newborns will have whole genome sequencing to enable personalised healthcare that predicts and prevents illness

All babies in England to get DNA test to assess risk of diseases within 10 years www.theguardian.com/science/2025...

If you're struggling to visualise mouse NMJs, we've got a protocol just for you!

bio-protocol.org/en/bpdetail?...

Dissection and whole-mount immunofluorescent staining of mouse hind paw muscles for #NMJ analysis

Lovely work from Rebecca Simkin @uclqsion.bsky.social @nicolbirsa.bsky.social‬

Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London on FindAPhD.com PhD Project - Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London, listed on FindAPhD.com

If you are looking for a PhD, are passionate about neurobiology and enjoy microscopy, come and join us for a PhD project on axonal pathophysiology in ALS!

www.findaphd.com/phds/project...
Applications close on Friday 4th July 2025

@mndassoc.bsky.social
@uclqsion.bsky.social

🌍 Por el #DíaMundialDeLaELA te invitamos a conocer SEED-ALS, proyecto colaborativo y multidisciplinar que impulsa la investigación en ELA

📣Si eres paciente, familiar o asociación
🗓 18 de junio
🕐 13:00h

🔗 Enlace: teams.microsoft.com/l/meetup-joi...

¡Conéctate! 🌱
#ELA #CienciaxELA

Brian Wilson, visionary creative spirit for the Beach Boys, dies aged 82 Musician, who suffered from mental health problems, wrote and produced the 1966 album Pet Sounds – seen by many as the greatest album of all time Brian Wilson, the Beach Boys musician, songwriter and producer who created some of history’s most purely beautiful pop music, has died aged 82. In a post shared on Instagram on Wednesday, Wilson’s family wrote: “We are heartbroken to announce that our beloved father Brian Wilson has passed away. We are at a loss for words right now. Please respect our privacy at this time as our family is grieving. We realize that we are sharing our grief with the world. Love & Mercy.” Continue reading...

Brian Wilson, visionary creative spirit for the Beach Boys, dies aged 82

DNA-guided transcription factor interactions extend human gene regulatory code - Nature A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1
www.nature.com/articles/s41...

🔴 NEWS |

"Desarrollan en el #IBiS el primer ratón modelo de una grave enfermedad neurodegenerativa un siglo después de su descubrimiento"

Noticia completa ➡️ www.ibis-sevilla.es/es/noticias/...

@csic.es @csicandalextrem.bsky.social @unisevilla.bsky.social

World’s first personalized CRISPR therapy given to baby with genetic disease Treatment seems to have been effective, but it is not clear whether such bespoke therapies can be widely applied.

A baby boy with a devastating genetic disease is thriving after becoming the first known person to receive a bespoke, CRISPR therapy-for-one, designed to correct his specific disease-causing mutation

https://go.nature.com/45bprqu

"Researchers recruited to work in the UK have to fund a £1,035 annual immigration health surcharge, which must be paid in full in advance, as well as up to £1,519 in visa fees. For a family of four, the upfront costs can total almost £30,000."

Unsplash image of the Earth, mostly the nightside with a tracery of city lights on every continent.

OK, this is wild.

In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.

It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.

What the HELL?

1/

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial With this treatment schedule, IL-2LD resulted in a non-significant reduction in mortality in the primary unadjusted analysis. However, the difference between the results of unadjusted and adjusted ana...

Our paper describing the results of the MIROCALS trial of low-dose interleukin-2 in #ALS #MND is out in the Lancet @thelancet.bsky.social

Open access

Read it here:
www.thelancet.com/journals/lan...

🔴 Consulta la convocatoria y bases de la 'Subvención para la adquisición de equipamiento científico-técnico para la I+D+i en biomedicina'. El #CabildodeTenerife dedica 435.000€ en ayudas a organismos públicos de investigación en #biomedicina en #Tenerife
www.fundacionbioavance.org/tablon-de-an...

Including a hopefully useful table with all currently available TDP-43 mouse strains and how they model the different aspects of TDP-43 pathology.

Our new review on the challenges of modelling TDP-43 pathology in mice is just out:
rdcu.be/ejZ5a
As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.

Sung Min Son & David Rubinsztein (UK DRI Cam) have identified a key enzyme driving forms of Parkinson’s. Blocking it restores normal function in animal and cell models, offering a promising new drug target.
www.clinical-neuroscience.cam.ac.uk/news/metabol...

@ukdri.ac.uk @camneuro.bsky.social

Opinion | Larry David: My Dinner With Adolf When a private meeting goes unexpectedly.

Maravilloso.

www.nytimes.com/2025/04/21/o...

Unthinkable just 10 years ago:

Almost 3/4 of the EU’s electricity in 2024 was from renewable energy sources and nuclear.

Gas and coal electricity generation is at record low levels.

Donald Trump has added a political risk premium to US assets Parking money in America is no longer the routine, fuss-free, neutral option

"As Lech Wałęsa once remarked, you can’t turn a fish soup back into an aquarium. It is hard to see a path back to normality." My colleague @katie0martin.ft.com excellent on the Trump hit to America's safe haven status. www.ft.com/content/fbe7...

We are witnessing the destruction of science in America | Paul Darren Bieniasz If we stay on this administration’s course, future life-saving medicines may never be invented

We are witnessing the destruction of science in America | Paul Darren Bieniasz

Fantastic graphic from the WSJ. Trump just increased the price of a iPhone by nearly 60 percent. Obviously completely unsustainable so won’t be sustained. An American Liz Truss moment

Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic aggregation ...

Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...

Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @science.org @evolutionvu.bsky.social @rokaslab.bsky.social

www.science.org/doi/10.1126/...