Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer Aberrant microRNA expression is common in cancer, yet cell-type-specific microRNA activity in the tumor microenvironment (TME) remains poorly understood. Here, we show that germline deletion of miR-21...

We’re pleased to share our new bioRxiv study:
Among the first glimpses of miRNA activity at single-cell resolution in situ in a solid tumor.
Loss of miR-21 slows MYC-driven prostate cancer and disrupts the immunosuppressive TME.
www.biorxiv.org/content/10.1...
#miRNA #ProstateCancer #scRNAseq