Richard Mead

‘Scientists will not be silenced’: thousands protest Trump research cuts Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.

Standing with all my fellow scientists in solidarity 🧪 www.nature.com/articles/d41...

www.facebook.com/share/p/16De...

Wow. Read this 👇

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social

www.nature.com/articles/s41...

(Collaborative work with Panos Roussos and his team! )

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

It is very important that our research programme is visible and accessible to everyone, because it is funded by the generosity of our supporters.

Great to catch up earlier today with some of our MND Association funded researchers at SITraN, doing great work to understand and treat #ALS #MND

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

https://go.nature.com/4kd1vIu

Neuronal polyunsaturated fatty acids are protective in ALS/FTD Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...

Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf

I'm looking to see if the cuts & chaos at CDC and NIH have affected any clinical trials or research for drugs for the treatment of cancer, Alzheimer's, Parkinson's, or other serious diseases. If you know anything, please contact me at DavidCorn.99 at Signal.

Or if you have any other good stories.

Check out our new review of C9orf72 ALS in @thelancetneuro.bsky.social with Sarah Mizielinska, Rosa Rademakers and others! Was fun to co-write but tough to collate such incredible progress into a one article: authors.elsevier.com/c/1ke765FFzL...

A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds Summary: A C9orf72 bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifested ‘space cadet syndrome’ on two FVB backgrounds. Genetic backgrounds should thus be considered ...

New paper in collaboration with James Alix and others. No phenotype in the Liu et al (2016) C9orf72 BAC ALS model on either the Jax labs or Janvier FVB genetic backgrounds. The background itself has a known neurological phenotype which we confirmed.

journals.biologists.com/dmm/article/...

An infographic with the following text: Health apprenticeships at a glance 1,048 students have started health apprenticeships at the University of Sheffield 146 - the number of NHS Trusts, healthcare organisations and other employer partners we work with 84% Achievement rate - 34% above the national average (2022/23 academic year) “Good” - the Ofsted Rating we received at our latest inspection (published in January 2025), in recognition of the quality of our apprenticeships According to the GOV.UK 'Find apprenticeship training' service we have been rated "Excellent" by employers and "Good" by apprentices

What better way to bring #NationalApprenticeshipWeek to a close than by taking note of our achievements as a health apprenticeships provider?🎉
Here's just some of the reasons we have to celebrate this #CelebrationFriday ⬇️
@sheffielduni.bsky.social

🚨 A groundbreaking drug screening programme is set to transform MND treatment!

🔬 EXPERTS-ALS will rapidly assess potential ALS drugs, testing their ability to slow nerve damage before large trials.

www.sheffield.ac.uk/news/groundb...

Please sign if you believe the Royal Society needs to stand up for values we all hold dear

An update on Ellorarxine - UKMNDRI Why this statement? As neurologists specialising in the care of people living with motor neuron disease, we are receiving increasing enquiries about a drug called ellorarxine. Many of our patients are...

Our statement on Ellorarxine in #ALS #MND

Testing a drug takes a lot of time, a lot of commitment from people living with MND, and a lot of money. We must be sure that we put our efforts in the right place to find new and effective treatments as quickly as possible.

ukmndri.org/2025/02/07/a...

Associate or Senior Editor, Nature Communications (Stem Cell and Developmental Biology) Title: Associate or Senior Editor, Nature Communications (Stem Cell and Developmental Biology) Location(s): New York, Jersey City, Philadelphia, Berlin or Heidelberg Application Deadline: About Spring...

My team @naturecomms.bsky.social is looking for a new editor! We need someone to help handle all of the awesome #stemcell and #devbio papers we're getting. DM me if you're interested or have questions about the role or interview process.
springernature.wd3.myworkdayjobs.com/en-US/Spring...

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x

Nice paper from the Barmada lab (not on here?) and highly actionable target for TDP-43 proteinopathy in ALS? We certainly need more of those!

Bill Gates calls Elon Musk’s embrace of far-right politicians abroad ‘insane shit’ Microsoft co-founder and philanthropist calls fellow tech titan ‘super-smart’ but guilty of ‘overreach’

Well not all tech titans are alike. Bill Gates is indeed doing God's work! www.theguardian.com/us-news/2025...

Nice job. Are you available to quote for some work?

Maximizing the translational potential of neurophysiology in amyotrophic lateral sclerosis: a study on compound muscle action potentials Mouse models of amyotrophic lateral sclerosis (ALS) enable testing of novel therapeutic interventions. However, treatments that have extended survival in mice have often failed to translate into hu...

Please check out our new paper using CMAP to bridge from preclinical to clinical studies in ALS.

Mouse models have been blamed for clinical failures, but how you use them is key. This approach is one step towards improving discovery of new drugs for ALS

www.tandfonline.com/doi/full/10....