Jatin Nagpal

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria - Nature Microbiology A comprehensive genomic analysis reveals species- and strain-level heterogeneity in carbohydrate utilization potential across bifidobacteria of human origin.

New RESOURCE!

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co

#microbiomesky #microsky

www.nature.com/articles/s41...

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025.

Please Share

@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...

🧠 How does your gut talk to your brain? We’re diving into the Gut-Brain Axis at #BCNMicrobiome with two leading voices: Jane Foster from #UTSWMedCenter on Microbiome & Depression and @maburto.bsky.social on Microbiota-Brain Communication

Honoured and delighted to join the board of directors at ALBA Network. I look forward to contributing to the ALBA mission to promote equity and inclusion in neuroscience.
@ucc.ie @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social

Genomics of host–microbiome interactions in humans Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...

Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field.
rdcu.be/epoRR

@blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.

When all this pollution is causing you headaches...

💪🦠

Exciting fundamental discovery!

Early embryos fight bacteria WITHOUT immune cells

Zebrafish, mouse, and human embryos use epithelial cells (trophoectoderm)—not immune cells—to engulf and destroy 𝘌. 𝘤𝘰𝘭𝘪 and 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴

Hoijman Lab Barcelona 🇪🇸
𝘊𝘦𝘭𝘭 𝘏𝘰𝘴𝘵 𝘔𝘪𝘤𝘳𝘰𝘣𝘦

www.sciencedirect.com/science/arti...

Eight Arms to Taste Your Microbiome

This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...

A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain https://www.biorxiv.org/content/10.1101/2025.06.10.658982v1

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome

The microbiome for clinicians Preclinical studies suggest a rapidly growing potential for the application of microbiome research in improving patient outcomes. This perspective lays out the potential steps that can be taken toward...

Microbiome for the clinicians | Cell

www.cell.com/cell/fulltex...

Congratulations to APC's @jatinnagpal.bsky.social, @maburto.bsky.social, Koushika Chandrasekaran, Alexandre Cergneux & @drmoralesgarcia.bsky.social - INSPIRE MSCA who have won the Joint @ucc.ie Research Image of the Year for ‘Brain Pipelines’

Delighted to be awarded the joint @uccresearch.bsky.social image of the year for #zebrafish “Brain Pipelines”!

Great Team Effort - @maburto.bsky.social, @drmoralesgarcia.bsky.social, Koushika and Alex.

@apcmicrobiomeirel.bsky.social, @researchireland.ie, @zebrafishrock.bsky.social

International Booker Prize 2025: Indian author and translators are first to win with a short story collection Banu Mushtaq’s Heart Lamp, translated by Deepa Bhasthi, chronicles the lives of women in southern India

International Booker Prize 2025: Indian author and translators are first to win with a short story collection.

www.irishtimes.com/culture/book...

Grateful and proud to be among the 6 candidates on the ballot for joining the ALBA Network Board of Directors.

🗳️ Please vote and advance ALBA's actions for equity and diversity in neuroscience. Details: www.alba.network/elections

@ucc.ie
@apcmicrobiomeirel.bsky.social
@researchireland.ie

Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...

🥁 NEW:

Commentary in @cellcellpress.bsky.social!

by @msabrysarhan.bsky.social Giacomo Antonello @whansi.bsky.social @cengoni.bsky.social @dmascalzoni.bsky.social @leviwaldron1.bsky.social Nicola Segata, Christian Fuchsberger

www.cell.com/cell/fulltex...

1/4

Live bacteria in gut microbiome dictate asthma onset triggered by environmental particles via modulation of DNA methylation in dendritic cells Ramar et al. demonstrate that gut microbiome transplantation confers asthma predisposition elicited by maternal intra-airway exposure to environmental particles. Radiation sterilization or antibacteri...

Live bacteria in gut microbiome dictate asthma onset triggered by environmental particles via modulation of DNA methylation in dendritic cells | Cell Reports

www.cell.com/cell-reports...

A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis The gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction–associated steatohepatitis (MASH). Fungi are increasingly recognized as importa...

Researchers have found a new ally in the fight against a serious liver disease: a symbiotic gut-dwelling fungus that produces a molecule shown to be capable of reversing disease progression in mice. scim.ag/42ZzVrC

In utero human intestine contains maternally derived bacterial metabolites - Microbiome Background Understanding when host-microbiome interactions are first established is crucial for comprehending normal development and identifying disease prevention strategies. Furthermore, bacterially...

In utero human intestine contains maternally derived bacterial metabolites | Microbiome

microbiomejournal.biomedcentral.com/articles/10....

Our children will face unprecedented exposure to weather extremes.

Our paper led by Luke Grant and @wimthiery.bsky.social published in @nature.com shows that the generation of our children and grandchildren will be exposed to a lot more weather extremes than ours.

www.nature.com/articles/s41...

Many Congrats!

Gut commensal Phascolarctobacterium faecium retunes innate immunity to mitigate obesity and metabolic disease in mice - Nature Microbiology Gut microbiome member, Phascolarctobacterium faecium, mitigates the inflammatory phenotype associated with obesity by retuning the innate immune response in a mouse model of diet-induced obesity.

Gut commensal Phascolarctobacterium faecium retunes innate immunity to mitigate obesity and metabolic disease in mice. | Nature Microbiology

www.nature.com/articles/s41...

“Singularity (after Stephen Hawking)” by Marie Howe Poem by Marie Howe. Text and context: https://www.themarginalian.org/2020/04/23/singularity-marie-howe-animated/ Created for The Universe in Verse: https://www.themarginalian.org/the-universe-in-vers...

Marie Howe wins the 2025 #Pulitzer Prize for poetry.

vimeo.com/411239105

Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain - Nature Microbiology ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal information associated with e...

🚨 Out now!

Chronostrain - a method to profile low abundance strains in longitudinal microbiome samples 🦠💻

@travis.gibsonlab.io @younhk.bsky.social @gibsonlab.io @harvardmed.bsky.social @broadinstitute.org

#MicroSky 🦠 #MicrobiomeSky

www.nature.com/articles/s41...

A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis The gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction–associated steatohepatitis (MASH). Fungi are increasingly recognized as importa...

A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite–CerS6–ceramide axis. | Science

www.science.org/doi/10.1126/...

The gut-brain axis mechanism of normal appetite induced by kynurenic acid Feeding is a fundamental requirement for the survival of host and gut microbiota. Here, Pan et al. discovered how gut microbiota influences feeding behavior through KYNA. During fasting, increased KYN...

The gut-brain axis mechanism of normal appetite induced by kynurenic acid | Cell Reports

www.cell.com/cell-reports...

The image is a screenshot of a 2-page article titled James Baldwin: ignorance, power, justice

To mark the centenary of James Baldwin, I wrote a short essay for @TheLancet. On what he's taught me about responding to pushback.

To beware of "strategic ignorance" and "the imaginary line of selective judgment".

James Baldwin: ignorance, power, justice - www.thelancet.com/journals/lan...