Jiri Hofbrucker's Avatar

Jiri Hofbrucker

@deepjdog.bsky.social

Empowering neuroscientists with fiber-based microscopic systems for imaging at any brain depth CTO at DeepEn, @deepen-imaging.bsky.social ( https://deepen-imaging.com/ )

549 Followers  |  513 Following  |  21 Posts  |  Joined: 13.11.2024  |  1.7712

Latest posts by deepjdog.bsky.social on Bluesky

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As Neurophotonics developers, we love learning about in vivo imaging directly from scientists.
We’re recruiting 20participants for our in vivo imaging survey.
⏱️ ~10 min
🎁 Free neuron socks
Work with in vivo animal imaging? Contact us at info@deepen-imaging.com.
#neuroscience #microscopy#neuroimaging

12.02.2026 10:09 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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As Neurophotonics developers, we love learning about in vivo imaging directly from scientists.
We’re recruiting 20participants for our in vivo imaging survey.
⏱️ ~10 min
🎁 Free neuron socks
Work with in vivo animal imaging? Contact us at info@deepen-imaging.com.
#neuroscience #microscopy#neuroimaging

12.02.2026 10:09 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

πŸš€ Excited to announce that I'm looking for people (PhD/Postdoc) to join my Cognitive Modelling group @uniosnabrueck.bsky.social.

If you want to join a genuinely curious, welcoming and inclusive community of Coxis, apply here:
tinyurl.com/coxijobs

Please RT - deadline is Jan 4‼️

18.12.2025 14:52 β€” πŸ‘ 76    πŸ” 54    πŸ’¬ 1    πŸ“Œ 5
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#SfN25 is now over!
Thanks to all the lovely people who came to our booth and shared their science stories with us!
It was an inspirational week for DeepEn!
Thanks to @sfn.org for an extraordinary meeting!

20.11.2025 16:18 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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πŸ§ πŸ“’ New preprint alert

Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧡

#neuroskyence #compneurosky

05.12.2025 20:42 β€” πŸ‘ 72    πŸ” 31    πŸ’¬ 3    πŸ“Œ 1
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DeepEn is at NEUROSCIENCE 2025 #SfN25 ! πŸ§ πŸ”¬πŸŒ΄
Come to our BOOTH #3027, check our microendoscope for deep brain imaging with sub cellular resolution and minimal tissue damage.
And meet Hana, Tomas, Patrick and Jiri!

#neuroimaging

17.11.2025 17:22 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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I'm excited to join #SfN2025 next week. Stop by booth #3027 to connect and learn more about structural and functional imaging in-vivo anywhere in the brain! I’d love to hear about your research and ideas! Looking forward to meeting you there.

07.11.2025 07:36 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: β€œCyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, β€œEngineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.

Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: β€œCyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, β€œEngineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.

This new miBrain model from MIT has it all:

🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
βš™οΈ Key features & functions of the human brain
πŸ‘©β€πŸ‘¦ Specificity to individual donors
🧬 Customizability via gene editing
πŸ“ˆ Scalability for large projects

03.11.2025 19:31 β€” πŸ‘ 22    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0
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High-resolution insights from the deep brain Discover the world’s best science and medicine | Nature.com

🧠What do neuroscientists think of DeepEn's holographic microendoscope?
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?

⭐ Check the Nature’s article:
www.nature.com/articles/d42...

07.10.2025 11:53 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Excited to share we’ve been awarded the ERC StG πŸŽ‰ for our project ProSocial, studying neural mechanisms of prosocial behavior in health & disease. Huge thanks to my group for their amazing work & to great colleagues for their support! Positions opening soonβ€”reach out if interested!

04.09.2025 14:20 β€” πŸ‘ 25    πŸ” 5    πŸ’¬ 7    πŸ“Œ 0
DeepEn hiring Neuroscience Imaging Scientist (Microscopy + Applications) in Jena, Thuringia, Germany | LinkedIn Posted 8:01:32 PM. DeepEn develops minimally invasive microendoscopes for neuroscience applications. We transform a…See this and similar jobs on LinkedIn.

Are you the kind of neuroscientist who scripts analysis or can’t resist tinkering with hardware?
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...

02.09.2025 06:12 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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5th Day of Intravital Microscopy - German BioImaging Intravital microscopy (IVM) enables the observation and precise quantification of cellular processes within native tissue microenvironments, with resolutions unmatched by other techniques. This powerf...

⏰ Reminder: The early bird registration and abstract submission for our 5th Day of Intravital Microscopy close on September 5!
Don’t miss your chance to join us in TΓΌbingen on 18–19 Sept. Secure your spot today!
πŸ‘‰ bit.ly/3IOlJtJ

01.09.2025 08:25 β€” πŸ‘ 6    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Beautiful work!

01.09.2025 09:22 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Fun collaborative work together with the amazing lab of @sophiesteculorum.bsky.social now published!

11.06.2025 14:36 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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A mouse brain stereotaxic topographic atlas with isotropic 1-ΞΌm resolution - Nature A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-ΞΌm resolution, achieved through continuous micro-optical sectioning tomography, promise...

www.nature.com/articles/s41...

07.07.2025 15:30 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

A fantastic overview of where three-photon microscopy stands relative to existing methods. It's clear that while the technology is still maturing, its advantages for deep-brain imaging!

07.07.2025 07:17 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Hippocampal vasculature is so pretty 😍
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy

14.05.2025 21:25 β€” πŸ‘ 35    πŸ” 5    πŸ’¬ 3    πŸ“Œ 0
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Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity and altered tuning of fa...

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...

08.05.2025 19:51 β€” πŸ‘ 25    πŸ” 10    πŸ’¬ 1    πŸ“Œ 1
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Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!

20.01.2025 10:22 β€” πŸ‘ 49    πŸ” 28    πŸ’¬ 2    πŸ“Œ 2
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Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)

TH staining in cyan
Virus injection in magenta

Zona Incerta is definitely a tough cookie πŸͺ but getting there!

01.05.2025 18:58 β€” πŸ‘ 22    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Beautiful axons indeed! A quick technical question. What technique did you use to target the amygdala during ferrule implantation?

03.05.2025 12:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
A picture of a gigaseal during electrophysiological recording in neuron.

A picture of a gigaseal during electrophysiological recording in neuron.

🧠 GABA! πŸ”¬βœ¨Explore groundbreaking research on the GABAergic system and its role in health and disease in humans and rodents.
Learn more by joining us #NeuronsInAction2025!
πŸ“the Nencki Institute, Warsaw, Poland
πŸ“… 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute

30.03.2025 19:31 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Excellent Norbert Elsner Lecture by Rui Costa @ruimcosta.bsky.social, GΓΆttingen Meeting of @neurowissg.bsky.social

28.03.2025 08:30 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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πŸ“£ 1 week to go!

Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 πŸ”¬

πŸ“at the 16th GΓΆttingen Meeting of the German Neuroscience Society

Come to our booth and tell us about your research ideas!
#NWG2025
#GΓΆttingenMeeting
#Neuroscience

20.03.2025 12:31 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
In vivo image captured of a neuron labeled with a calcium indicator

In vivo image captured of a neuron labeled with a calcium indicator

Just so happened to see this beauty today while recording in Kash Lab @superkash.bsky.social. Happy #FluorescenceFriday πŸ€©πŸ”¬

14.03.2025 22:18 β€” πŸ‘ 36    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Happy #BrainAwarenessWeek! Join this international celebration of the brain with this visual exploration of its makeup and neighborhoods: alleninstitute.org/news/what-ar...

πŸ§ πŸ“ˆ @danafoundation.bsky.social

13.03.2025 18:48 β€” πŸ‘ 13    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0
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Do you want to join a great team and work on cutting-edge confocal microscopy systems?

Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!

Apply here: confocal.recruitee.com/o/product-ap...

10.03.2025 12:43 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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MAC lab How does our prior knowledge impact how we learn new information? How do memories change over time? We use cognitive neuroscience methods to understand how the brain stores, organizes, and transforms ...

The MAC lab is hiring a full-time lab manager to start in June! You will have the opportunity to conduct research projects relating to long-term memory and concept knowledge (methods include online and in-person behavioral experiments, fMRI, TMS). Apply by March 26 careers.drexel.edu/cw/en-us/job...

10.03.2025 20:55 β€” πŸ‘ 12    πŸ” 10    πŸ’¬ 1    πŸ“Œ 1
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As part of #NEUROGATE, the Haesler lab is helping develop a holographic endoscope for high-resolution, deep-brain imaging. Supported by a €2.5M EIC grant, this ultra-thin fiber technology could transform neuroscience & neurotech.
nerf.be/en/news#/new...

11.02.2025 10:22 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
β€œWith NEUROGATE, we are taking it to the next level to study neuronal activity under natural conditions with unprecedented precision. These findings could significantly expand our understanding of neurological diseases.” TomΓ‘Ε‘ ČiΕΎmΓ‘r, Institute of Scientific Instruments of the CAS

β€œWith NEUROGATE, we are taking it to the next level to study neuronal activity under natural conditions with unprecedented precision. These findings could significantly expand our understanding of neurological diseases.” TomΓ‘Ε‘ ČiΕΎmΓ‘r, Institute of Scientific Instruments of the CAS

The research team from @leibnizipht.bsky.social, DeepEn, the Institute of Scientific Instruments @czechacademy.bsky.social & @nerflabs.bsky.social is developing this innovative imaging technology to visualize neuronal processes in living organisms with high precision.

03.02.2025 13:07 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

@deepjdog is following 20 prominent accounts