Jiri Hofbrucker

High-resolution insights from the deep brain Discover the world’s best science and medicine | Nature.com

🧠What do neuroscientists think of DeepEn's holographic microendoscope?
How can they use it to study learning and memory processes?
Can it enable voltage imaging in deep brain structures to study processes behind neuronal firing?

⭐ Check the Nature’s article:
www.nature.com/articles/d42...

Excited to share we’ve been awarded the ERC StG 🎉 for our project ProSocial, studying neural mechanisms of prosocial behavior in health & disease. Huge thanks to my group for their amazing work & to great colleagues for their support! Positions opening soon—reach out if interested!

Are you the kind of neuroscientist who scripts analysis or can’t resist tinkering with hardware?
At DeepEn we’re building a fluorescence microscope to image deep in the brain through a single optical fiber. Join us to hack the future of neuroimaging: #ScienceJob
www.linkedin.com/jobs/view/42...

5th Day of Intravital Microscopy - German BioImaging Intravital microscopy (IVM) enables the observation and precise quantification of cellular processes within native tissue microenvironments, with resolutions unmatched by other techniques. This powerf...

⏰ Reminder: The early bird registration and abstract submission for our 5th Day of Intravital Microscopy close on September 5!
Don’t miss your chance to join us in Tübingen on 18–19 Sept. Secure your spot today!
👉 bit.ly/3IOlJtJ

Beautiful work!

Fun collaborative work together with the amazing lab of @sophiesteculorum.bsky.social now published!

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...

www.nature.com/articles/s41...

A fantastic overview of where three-photon microscopy stands relative to existing methods. It's clear that while the technology is still maturing, its advantages for deep-brain imaging!

Hippocampal vasculature is so pretty 😍
(mouse hippocampus perfused with Tomato Lectin and cleared)
#Neuroscience #Microscopy

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity and altered tuning of fa...

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...

Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!

Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)

TH staining in cyan
Virus injection in magenta

Zona Incerta is definitely a tough cookie 🍪 but getting there!

Beautiful axons indeed! A quick technical question. What technique did you use to target the amygdala during ferrule implantation?

A picture of a gigaseal during electrophysiological recording in neuron.

🧠 GABA! 🔬✨Explore groundbreaking research on the GABAergic system and its role in health and disease in humans and rodents.
Learn more by joining us #NeuronsInAction2025!
📍the Nencki Institute, Warsaw, Poland
📅 27-31 May, 2025
#nia2025 #neuronsinaction2025 #neuroscience #brain #nenckiinstitute

Excellent Norbert Elsner Lecture by Rui Costa @ruimcosta.bsky.social, Göttingen Meeting of @neurowissg.bsky.social

📣 1 week to go!

Get ready for a LIVE DEMO of our Holographic Microendoscope for high resolution deep brain imaging 🧠 🔬

📍at the 16th Göttingen Meeting of the German Neuroscience Society

Come to our booth and tell us about your research ideas!
#NWG2025
#GöttingenMeeting
#Neuroscience

In vivo image captured of a neuron labeled with a calcium indicator

Just so happened to see this beauty today while recording in Kash Lab @superkash.bsky.social. Happy #FluorescenceFriday 🤩🔬

Happy #BrainAwarenessWeek! Join this international celebration of the brain with this visual exploration of its makeup and neighborhoods: alleninstitute.org/news/what-ar...

🧠📈 @danafoundation.bsky.social

Do you want to join a great team and work on cutting-edge confocal microscopy systems?

Join us at Confocal NL as a Product Application Specialist and help researchers globally accelerate their discoveries with our disruptive technology!

Apply here: confocal.recruitee.com/o/product-ap...

MAC lab How does our prior knowledge impact how we learn new information? How do memories change over time? We use cognitive neuroscience methods to understand how the brain stores, organizes, and transforms ...

The MAC lab is hiring a full-time lab manager to start in June! You will have the opportunity to conduct research projects relating to long-term memory and concept knowledge (methods include online and in-person behavioral experiments, fMRI, TMS). Apply by March 26 careers.drexel.edu/cw/en-us/job...

As part of #NEUROGATE, the Haesler lab is helping develop a holographic endoscope for high-resolution, deep-brain imaging. Supported by a €2.5M EIC grant, this ultra-thin fiber technology could transform neuroscience & neurotech.
nerf.be/en/news#/new...

“With NEUROGATE, we are taking it to the next level to study neuronal activity under natural conditions with unprecedented precision. These findings could significantly expand our understanding of neurological diseases.” Tomáš Čižmár, Institute of Scientific Instruments of the CAS

The research team from @leibnizipht.bsky.social, DeepEn, the Institute of Scientific Instruments @czechacademy.bsky.social & @nerflabs.bsky.social is developing this innovative imaging technology to visualize neuronal processes in living organisms with high precision.

Dr. Jörg Philipps erhält den Robert Wartenberg-Preis 2025 für seine Arbeiten zu diagnostischen Anwendungen des hochauflösenden Nervenultraschalls in der #Neurologie. Herzlichen Glückwunsch! 👉 dgn.org/artikel/robe... #neuroskyence
Foto:© DGN/Claudius Pflug

Happy to provide a #TIM2025 Workshop and present together with Dr. Peter Hemmerich, from the CF Imaging of the Leibniz Institute on Aging – FLI, image Quality Control, restoration, deconvolution, denoising, and analysis of confocal and STED data. #microscopy #science

Excited to attend the 16th Göttingen Meeting of the @neurowissg.bsky.social in three weeks! Looking forward to insightful discussions and cutting-edge research. If you're attending, let’s connect—I’d love to catch up in person!
See you in Göttingen! 🚀🔬 #Neuroscience #GöttingenMeeting #NWG2025

🧠Job Opening!🧠

We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.

Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!

An innate drive to save a life In mice, two brain regions drive the impulse to revive an unconscious companion

Activation of neurons in the medial amygdala and oxytocin-expressing neurons in the hypothalamic paraventricular nucleus drive the impulse to revive an unconscious companion...

An innate drive to save a life | Science
#neuroskyence

www.science.org/doi/10.1126/...

Be part of our groundbreaking science!
We're hiring a Project Coordinator to support our research team.
Apply now: www.jobs.cam.ac.uk/job/50370/
Please share! #hiring #projectcoordinator #sciencejobs

🚀 We’re Hiring a Photonics Scientists
DeepEn develops minimally invasive microendoscopes for neuroscience applications. Using holographic light control, we transform a single optical fiber into a hair-thin imaging device, bringing microscopy into deep brain regions.
lnkd.in/ee6VMNaM
#ScienceJobs

a drawing of a brain with a rainbow and a blue one Alt: a drawing of a brain with a rainbow on one hemisphere and blue on the other

🚨 Job alert 🚨

We have a 1-year post-doc position available at @exetermed.bsky.social with @craigbeall-lab.bsky.social to study the impact of maternal diet on astrocytes during development.

Friendly and inclusive team in a beautiful location.
Application deadline 5th March

tinyurl.com/3zhd8wsm