Febri Gunawan Sugiokto

Photo: Cecilia Odlind

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

2025 Nobel Prize in Physiology or Medicine #nobelprize

E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Strengthening nucleic acid biosecurity screening against generative protein design tools www.science.org/doi/10.1126/... 🧬🖥️🧪

Imagine a scientific journal called Infection and Immunity not focusing on viruses and the immune response?!

Congrats!

Our enthusiastic student talk: Febri Gunawan Sugiokto from PMI
#bgsa #symposium #studenttalks

Check out PMI talks tomorrow at the SOM Grad Student Symposium:
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !

ASM 🥳

Faculty Professor Associate - Full-Time | Vaughn Cooper We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

ASM Issues Joint Statement Calling For Secretary Kennedy Resignation The American Society for Microbiology joined national medical, scientific, public health and patient organizations to call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Protecting public health is our responsibility as physicians, scientists and patient advocates. It is also the responsibility of our elected officials, and we call for their support at this critical moment to protect the health of the nation.

Thanks to @asm.org and colleagues for stadning up for public health. Call Congress today and demand Kennedy's resignation
asm.org/press-releas...

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

As RFK testifies in front of the Senate today, ASV wants to emphasize the risks posed by his decisions related to virus outbreaks and the public health of Americans. Together with our partner organizations, we call for RFK's resignation: asm.org/press-releas...

🧬 New preprint! We find PIAS1 regulates EBNA1, the key EBV protein for episome maintenance. PIAS1 binds oriP & SUMOylates EBNA1, stabilizing episomes + restricting lytic replication. 🚨 PIAS1 may also regulate KSHV & HPV → a potential pan-viral therapeutic target?

EBNA1 SUMOylation by PIAS1 Suppresses EBV Lytic Replication and Enhances Episome Maintenance https://www.biorxiv.org/content/10.1101/2025.09.01.673444v1

Congrats

Congrats

Win for #openscience!

Mars: simplifying bioinformatics workflows through a containerized approach to tool integration and management academic.oup.com/bioinformati... 🧬🖥️🧪 github.com/GenomicAI/mars

NIH PostBac program is open again! And I will be hiring! #JobPostComing

www.training.nih.gov/research-tra...

US reviewing federal contracts, grants to Harvard over antisemitism allegations The administration of Republican President Donald Trump announced a review on Monday of federal contracts and grants at Harvard University over allegations of antisemitism.

Challenging times.

Harvard at risk of losing $9 billion in federal funds as US launches review

www.reuters.com/world/us/us-...

It even can make western blot result out of nowhere 😢😢😢 @thatsregrettab1.bsky.social

2 years, 100+ citations amazing

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New this evening (3/28): Major update in NIH grant termination numbers.

❌ 695 NIH grants now terminated (up from 429)
❌ 232 on HIV/AIDS
❌ 44 on cancer
❌ 28 on Alzheimer's
❌ 123 on Covid*

*And this doesn't count cancelled non-NIH Covid grants.

HUGE THANKS to @noamross.net for pushing the updates!

Overseas universities see opportunity in U.S. ‘brain drain’ But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own

“If large numbers of academics working in the U.S. do decide to leave, Gold doubts other countries will be able to absorb them all. The end result, he warns, could be an exodus of talent from global science. “My biggest fear,” he says, is that “we’re going to lose a cohort of researchers.”” 🧪

These frustrated scientists want to leave the United States – do you? Take Nature’s poll Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.

Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration

Are you thinking about leaving?

https://go.nature.com/4bMGd0J

Many forms of Long Covid: Long Covid is a multisystemic disease with sequelae that affect almost all organ systems. Various putative mechanisms that underlie these sequelae are not mutually exclusive and may explain the myriad health effects seen in Long Covid. Therapeutics that target these pathways, such as antivirals, anti-inflammatory agents, microbiome restoration, and anticoagulant drugs, may ameliorate symptoms.

A #SciencePerspective by @zalaly.bsky.social and @erictopol.bsky.social identifies key issues that need to be prioritized in the study of #LongCovid.

Learn more on #LongCovidAwarenessDay: scim.ag/3XKbds3

TGFβ links EBV to multisystem inflammatory syndrome in children - Nature Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

Uncovering the road to MIS-C…

-TGFβ links EBV to multisystem inflammatory syndrome in children-

Brilliant work by a massively brilliant team.

#LongCovid #MISC #KD

www.nature.com/articles/s41...

This is really, really bad. Columbia made the mistake of thinking that placating the administration would spare them. Other universities made the mistake of thinking it would stop with Columbia. It won’t stop without disciplined pushback; it’s an existential question for American universities.

Thousands gather across U.S. in Stand Up for Science events Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration

Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4

PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...