Rob Hagan

A comparative analysis of the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models https://www.biorxiv.org/content/10.64898/2026.02.17.706422v1

Your anti-ageing stack should include this vaccine The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

We live in a bizarre world where longevity influencers tell millions to take rapamycin, sit in hyperbaric oxygen chambers, blast themselves with red light therapy, and take 50+ supplements daily. Meanwhile something that cuts dementia risk by 20% Is invisible.

open.substack.com/pub/overmatt...

I am an Epic Chat conscientious objector (ICU, not ID) for 2 reasons. 1- It is a constant interruption. 2- Communication (big C) is important and Epic Chat is usually low quality (little c) communication. If someone needs to talk to the ICU there are many ways and Epic Chat is not the right one.

Don't give up!

On the one hand, I think it's great that someone mapped Bluesky users. On the other hand, I'm a bitworried that I map at some kind of Lagrange point between "Biomedical Research Scientists" (totally makes sense) and..."Brazilian Young Adults on Bluesky". Where's the cycling group?

Jeff Bezos clarifies that newspapers also die in darkness

News In Photo:

I like my thylakoids the way I like my pancakes:

Stacked so densly it causes iridescence and apprears blue when lit at the right angle.

Honestly. There is no easy fix to <waves in GenX> alla this. But a starting place could be to address the CRIME of Citizens United. Corporations are NOT people. Money is NOT speech. And the place we're in right now? Owes a LOT to those two things being perverted by Citizens United.

We've got ISSUES. Literally.

We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?

arxiv.org/abs/2601.07563

A 🧵 1/n

How does SARS-CoV-2 infection lead to dysregulation of the immune system in severe and #LongCovid?
An unanticipated mechanism described @pnas.org with depletion of specific immune T and dendritic cells, open-access
www.pnas.org/doi/suppl/10...

There must be an ICU snack that treats the headaches.

Spicy kimchi on baked potato.

As with Shakespeare, I always found myself coming out of a Stoppard play feeling more intelligent than when I went in.

A display of cheeses. Two in the front are vaguely torus shaped, sliced in half so you can see the shape, like a bagel cut in half to make two u-shapes. They look like drawings of the disk of matter around a black hole, narrow in the middle and flared on the outside.

For the astronomers: I found an accretion disk diagram cheese. A quesar.

A screen shot of the antibiotic personality quiz

It’s World AMR Awareness Week, and this year I had the honor to re-imagine and doodle the antibiotics in the antibiotic personality quiz 😇🖍️
Thank u @brxad.bsky.social for this amazing and fun opportunity!

C’mon, take the quiz, it’s a #WAAW tradition 😉💊
#IDSky

quiz.tryinteract.com#/59e68e3a8ec...

My residency director used to say never have more than 2 if you're on call.

Fairy Liquid unveiled as secret ingredient in University of Cambridge scientists’ near-universal magic formula It helps them with experiments studying the inside of cells.

It is not often that a new flow cytometry protocol makes the newspaper! I also got a kick out of seeing our science tagged as "quirky"!

www.cambridgeindependent.co.uk/news/fairy-l...

Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting

I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:

Rats filmed snatching bats from air for first time Stunning hunting behaviour captured in German cave

New - my first piece for @science.org !

Absolutely crazy footage of rat behaviour in Germany.

Rats filmed snatching bats from air for first time | Science | AAAS share.google/WAsAIQ8j0MKp...

An alien fleet appeared in Earth's orbit, and broadcast a message:

"Having studied you furtively, we now seek formal contact, and want to meet your greatest thinkers..."

A long list followed.

"How do we tell them?" world leaders wondered.

Topping the list were the names Calvin and Calvin's Dad.

Vital AF is the MICU vibe.

- calendar makes no sense
- half the riders and half the teams in most races don't influence the outcome
- Giro and Vuelta should be 2 weeks

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer Gene expression programs directed by MYC mediate oncogenic KRAS signaling in pancreatic cancer.

Researchers in #ScienceSignaling have mapped out the genetic and proteomic effects of a protein named MYC that is intimately linked to cancer growth—a discovery that could lead to new therapies aimed at this “undruggable” target. https://scim.ag/4nuQB1R

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Fox
Emily Kewageshig ~ Anishinaabe
2021

The drosophila Dscam1 gene presumably evolved specifically to mess with bioinformaticians

The Vuelta is a marshmallow. After the meal of the TdF, you neither want it nor need it. When you try it, it's briefly more enjoyable than you anticipated. And then you forget it ever happened. And then the next time you do it again.

I keep staring at this video showing the movement of aerosols in the atmosphere. It's so mesmerizing! That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Some people ride bikes for fitness, and others for transportation.

Some ride for _______

👇 ?