Matt Slein

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens www.biorxiv.org/content/10.64898/2026.01.26.701809v1 #cryoEM

Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...

I'm honored to receive a MacArthur Fellowship. As always, I extend my sincerest thanks to all my wonderful mentors, colleagues, collaborators, admins, and trainees who make this work possible. #MacFellow

Excited to have contributed to Volume 12 of Annual Review of Virology! www.annualreviews.org/content/jour...

Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice Glycoprotein B (gB) serves as the viral fusion protein for herpes simplex virus (HSV), mediating fusion between viral and host membranes resulting in infection. As such, gB represents a potentially cr...

Excited to share a portion of my PhD work describing the mechanisms of antibody-mediated protection against HSV infection. Here we show that a panel of 5 mAbs targeting gB all required Fc effector functions to be protective in a mouse model of neonatal HSV infection. www.biorxiv.org/content/10.1...

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates Nonstabilized SARS-CoV-2 spike mRNA vaccination elicited distinct antibodies to either Omicron variants of concern or preemergent sarbecoviruses.

A paper from our pancoronavirus vaccine P01 grant group is now out in Science Translational Medicine.

Here we show that non-stabilized spike delivered as mRNA is sufficient to elicit broadly neutralizing antibodies in monkeys.

@alexschaefer.bsky.social

www.science.org/doi/10.1126/...

Antibody-mediated restriction of M. tuberculosis is associated with reorganization of the tissue-level immune response to infection and depends on the collaboration of antibody Fab and Fc @cp-immunity.bsky.social Alter/Fortune
www.cell.com/immunity/ful...

A review I wrote for the upcoming issue of Annual Review of Virology is now live as a Review in Advance! tinyurl.com/ARV2025 Here we talk about the multifaceted role of maternal antibodies in protection against three important congenital viral infections. #virology

Successfully defended my thesis two weeks ago! Couldn’t have asked for better labs to do my PhD work in