Daniel Hurdiss

Automated removal of corrupted tilts in cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40741136/ #cryoEM

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

Virion motility of sialoglycan-cleaving respiratory viruses - npj Viruses npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses

New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

"Respiratory viral infections awaken metastatic breast cancer cells in lungs"

www.nature.com/articles/s41...

Antibody-like recognition of a γδ T cell receptor toward a foreign antigen Rashleigh et al. utilized phycoerythrin, a bacterial derived protein, to explore immune reactivity of B cells, αβ T cells, and γδ T cells. All lymphocytes directly recognized PE, while T cell recognit...

Excited to get some of my PhD work published! Utilising single particle cryo-EM we display convergent recognition by three lineages of lymphocyte to the same epitope.

#gdTcells #CryoEM

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

a bald man in a blue suit is making a face . ALT: a bald man in a blue suit is making a face .

Preprint on tandem split-GFP influenza viruses is now up! We strung 7 copies of GFP11 together to make a bright virus with minimal fitness defects. Fluorescence requires GFP1-10 from cells, so we made a few that are relevant for flu. See this fluorescent love story: www.biorxiv.org/cgi/content/...

Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale www.biorxiv.org/content/10.1101/2025.07.22.666177v1 #cryoEM

Alphaherpesvirus pUL21 homologues use non-canonical motifs to compete with cellular adaptors for protein phosphatase 1 binding Protein phosphatase 1 (PP1) is a key regulator of cellular phosphorylation and its activity is regulated via binding to cellular regulatory proteins via conserved short linear motifs (SLiMs). The herp...

How does #herpes hijack a human phosphatase to promote virus replication? We have a new @biorxivpreprint.bsky.social preprint showing how #HSV and #VZV use a novel motif to compete with canonical cellular #PP1 adaptors.
www.biorxiv.org/content/10.1...
🧵👇

New preprint: In situ Architecture of #Plasmodesmata.

Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.

🔗 doi.org/10.1101/2025...

🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

Capsid Restructuring Activates Semi-Conservative dsRNA Transcription in Cystovirus Φ6 www.biorxiv.org/content/10.1101/2025.07.23.666269v1 #cryoEM

Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...

"Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells"

www.biorxiv.org/content/10.1...

HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors pubmed.ncbi.nlm.nih.gov/40707428/ #cryoEM

Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets Prior infection with the 2009 pandemic H1N1 influenza virus confers protection against H5N1 infection and disease in ferrets.

Exciting new work from my @ciddpsu.bsky.social colleagues showing that pandemic H1N1 immunity reduces susceptibility to H5N1 infection and disease in ferrets.

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

Delighted to see our publication with industry partners out! 🎉
Huge shoutout to @jbrwhite.bsky.social and @oksana-degtjarik.bsky.social for their contributions to the structural work!
Many thanks to @chingshinhuang.bsky.social & the whole team for an excellent collaboration!
#CryoEM #drugdiscovery

Finally out!
I’m thrilled to share our new paper (Wolin et al., Cell 2025).

This paper describes SPIDR, a high-throughput method for mapping RBP binding sites.

By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110

Architecture and regulation of filamentous human cystathionine beta-synthase - Nature Communications Cystathionine beta-synthase is a conserved essential enzyme of one-carbon metabolism. Here, the authors show that the enzyme oligomerises to form filaments that undergo conformational and morphologica...

The EMPIAR datasets related to my work on human cystathionine beta-synthase are now released. Hopefully they are useful unusual filament cases for #cryoEM data processing
www.nature.com/articles/s41...
1. www.ebi.ac.uk/empiar/EMPIA...
2. www.ebi.ac.uk/empiar/EMPIA...
3. www.ebi.ac.uk/empiar/EMPIA...

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social

AlphaFold - A practical guide AlphaFold - A practical guide

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good!

There are also little quizzes and interactives.
www.ebi.ac.uk/training/onl...

The Trump administration is making viruses great again | Arwa Mahdawi Measles cases are at their highest rate in the US in decades. Robert F Kennedy doesn’t seem too bothered

The Trump administration is making viruses great again | Arwa Mahdawi

Virus glycoprotein nanodisc platform for vaccine design pubmed.ncbi.nlm.nih.gov/40666859/ #cryoEM

Cryogenic Electron Tomography Redefines Herpesvirus Capsid Assembly Intermediates Inside the Cell Nucleus pubmed.ncbi.nlm.nih.gov/40666836/ #cryoEM

A highly potent human antibody neutralizing all serotypes of BK polyomavirus Author summary BK polyomavirus (BKPyV) is a common virus that infects most people during childhood and typically remains dormant in the kidneys without causing harm. However, in kidney transplant pati...

"A highly potent human antibody neutralizing all serotypes of BK polyomavirus"

journals.plos.org/plospathogen...

As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3

Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome www.biorxiv.org/content/10.1101/2025.07.14.664651v1 #cryoEM

🚨 New @biorxivpreprint alert! 🚨
We are thrilled to share our latest findings—building on our earlier work on suppressors of helper NLRs of the NRC family—a Phytophthora infestans L-shaped effector captures resistosome assembly intermediates of tomato NRC3!
www.biorxiv.org/content/10.1...
1/10

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...