Daniel Hurdiss

A prophage-encoded abortive infection protein preserves host and prophage spread - Nature A Gifsy-1 prophage–encoded higher eukaryotes and prokaryotes nucleotide-binding protein, HepS, senses Siphoviridae infection, activates abortive defence by cleaving host transfer RNAs, blocks rival ph...

A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...

Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...

Tick-borne viruses: discovery, clinical aspects, influencing factors and control - Nature Reviews Microbiology Pathogenic tick-borne viruses (TBVs) are a global threat to public and veterinary health. In this Review, Cao and colleagues highlight the diversity of the tick virome, review human and animal TBV pathogens, outline clinical features of human TBV infections, describe factors impacting ticks and TBV spread, and discuss the need for integrated One Health control strategies.

Tick-borne viruses surge globally, driven by climate change and ecological shifts, challenging public health with rising infection complexity and control hurdles.

by Ye RZ, Li YY, Wang XY and Cao WC in Nat Rev Microbiol #MedSky

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Genomic features associated with sustained mammalian transmission of avian influenza A viruses Nature Microbiology, Published online: 27 January 2026; doi:10.1038/s41564-025-02257-4Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.

Out Now! Genomic features associated with sustained mammalian transmission of avian influenza A viruses #MicroSky

Check out our new paper in @natcomms.nature.com .com where we used #cryoEM together with biochemical and mutational analyses investigated the cotranslational protein folding by Ssb in yeast.

Publication: doi.org/10.1038/s41467-025-67685-6

Check below for the cryoEM centric feed. 👇

Australian strains of the avian coronavirus infectious bronchitis virus predominantly target the respiratory tract rather than the kidneys in specific-pathogen-free chickens Coronaviruses evolve rapidly, with recombination and mutation fostering the emergence of variant strains. The avian coronavirus infectious bronchitis virus (IBV) is an important poultry pathogen and a...

Australian strains of the avian coronavirus infectious bronchitis virus predominantly target the respiratory tract rather than the kidneys in specific-pathogen-free chickens

www.microbiologyresearch.org/content/jour...

The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis - npj Viruses npj Viruses - The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis

The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis

www.nature.com/articles/s44...

Genomic features associated with sustained mammalian transmission of avian influenza A viruses - Nature Microbiology Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.

Genomic features associated with sustained mammalian transmission of avian influenza A viruses

www.nature.com/articles/s41...

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens www.biorxiv.org/content/10.64898/2026.01.26.701809v1 #cryoEM

Recent Advances in Targeting Regions of Interest for In Situ Cryo-Electron Tomography of Cellular Architecture pubmed.ncbi.nlm.nih.gov/41581770/ #cryoEM

Regulatory hotspot on the influenza A virus polymerase revealed through the structure of the NEP-polymerase complex Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus.

Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought
www.science.org/doi/10.1126/...

Replicon-based genome-wide CRISPR knockout screening for the identification of host factors involved in viral replication - Nature Communications Cheng et al., use non-infectious stable viral replicon cell lines in genome-wide CRISPR KO screens across diverse viral pathogens to identify host factors specifically involved in the intracellular st...

www.nature.com/articles/s41...

Visualization of EGFR Assembly and Activation Induced by a Protein Nanocage Using Cryo-Electron Tomography pubmed.ncbi.nlm.nih.gov/41564420/ #cryoEM

Loss of α2,3-linked sialoside in the receptor-binding site of a H5N1 influenza hemagglutinin identified in a human patient www.biorxiv.org/content/10.64898/2026.01.19.700419v1 #cryoEM

Conserved assembly architecture of the essential herpesvirus packaging accessory factor www.biorxiv.org/content/10.64898/2026.01.22.701024v1 #cryoEM

Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...

Structural characterization of the HDV virion and its ribonucleoprotein pubmed.ncbi.nlm.nih.gov/41564123/ #cryoEM

Establishing the molecular basis for MDA5 mutation-linked autoimmunity www.biorxiv.org/content/10.64898/2026.01.20.700587v1 #cryoEM

Fully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography www.biorxiv.org/content/10.64898/2026.01.16.700029v1 #cryoEM

CL3- Research Assistant The Pirbright Institute The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic a...

Interested in high containment work on viruses?

We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...

Still more new NSP1 mutations in the BA.3.2 uploaded from the Netherlands today. We've never seen anything like this kind of rapid evolution in NSP1 (whose primary role is to shut down host-protein translation and degrade host mRNA).

I've labeled all BA.3.2-specific NSP1 muts here. 1/3

Dengue virus shaped the evolution of SARS-CoV-2 Two viruses can co-evolve in dengue-endemic regions

Dengue virus shaped the evolution of SARS-CoV-2 www.nature.com/articles/d44...

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

Strategic variations in sarbecovirus and merbecovirus Nsp1 linker regions for translation inhibition pubmed.ncbi.nlm.nih.gov/41538319/ #cryoEM

Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context www.biorxiv.org/content/10.64898/2026.01.15.699503v1 #cryoEM

The structure of a thermostable phage's portal vertex and neck complex illuminates the headful maturation mechanism pubmed.ncbi.nlm.nih.gov/41544933/ #cryoEM

Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter pubmed.ncbi.nlm.nih.gov/41544142/ #cryoEM

Back from the Physics of Viruses and Protein Cages GRC in the beautiful Tuscan hills. Great to see the latest developments in the field and to catch up with familiar faces.

Thanks to the organisers for the invitation to present, and to everyone I spoke with for the excellent discussions.

Cryo-EM structures of antibodies elicited by germline-targeting HIV MPER epitope scaffolds pubmed.ncbi.nlm.nih.gov/41528847/ #cryoEM