Daniel Hurdiss

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Recovery of infectious recombinant human norovirus using zebrafish embryos | PNAS www.pnas.org/doi/abs/10.1...

Structural and catalytic diversity of coronavirus proofreading exoribonuclease pubmed.ncbi.nlm.nih.gov/41361186/ #cryoEM

📄 Loop-mediated regulation and base flipping drive RNA cleavage by human mitochondrial PNPase

✍🏼 @bmhallberg.bsky.social @hdas29.bsky.social

📔Nucleic Acid Research @narjournal.bsky.social

✨New preprint!

🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬

🔗👇

A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement pubmed.ncbi.nlm.nih.gov/41352342/ #cryoEM

Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology pubmed.ncbi.nlm.nih.gov/41355025/ #cryoEM

Structural insights into VLDLR recognition by western equine encephalitis virus pubmed.ncbi.nlm.nih.gov/41353198/ #cryoEM

Insights into the structure and initial host attachment of the flagellotropic bacteriophage 7-7-1 pubmed.ncbi.nlm.nih.gov/41353512/ #cryoEM

Structural basis of Retron-Eco8-mediated anti-phage defense www.biorxiv.org/content/10.64898/2025.12.04.692459v1 #cryoEM

Lipid dependence of connexin-32 gap junction channel conformations pubmed.ncbi.nlm.nih.gov/41350533/ #cryoEM

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane - Communications Biology Multi-scale molecular dynamics simulations reveal that polymyxins form polymyxin-protein aggregates upon associating with the E. coli outer membrane thereby reducing lateral mobility of outer membrane...

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42...

To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo - Nature Communications The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of p6...

Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.

Molecular insights into species-specific ACE2 recognition of coronavirus HKU5 - Nature Communications This study reveals how the bat coronavirus HKU5 recognizes ACE2 receptors across mammals and birds, uncovering a cross-class receptor usage in coronaviruses and highlighting its potential for interspe...

Molecular insights into species-specific ACE2 recognition of coronavirus HKU5

www.nature.com/articles/s41...

Structural insights into the role of eIF3 in translation mediated by the HCV IRES pubmed.ncbi.nlm.nih.gov/41337487/ #cryoEM

The gH/gL/gO Complex of Elephant Endotheliotropic Herpesvirus 1A Functions as a Receptor Binding Complex https://www.biorxiv.org/content/10.64898/2025.12.03.692000v1

My favourite experiment in the whole study is the negative-stain polyclonal epitope mapping we did using elephant serum, affectionately known in the lab as Ellie-EMPEM 😄

A huge thank you to Tabitha, Ollie and the entire EEHV team for this fun and rewarding collaboration! Tabitha is the driving force behind the EEHV work in the Utrecht Virology Lab and, if you haven’t done so already, I encourage you to check out more of the fantastic work she has done in this area.

How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬

Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉

www.biorxiv.org/content/10.6...

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation A model for hit-and-run viral carcinogenesis in the bladder.

What causes bladder cancer initiating mutations?
Our paper in Science Advances asks the question: can BK virus infections of normal urothelium lead to the APOBEC3 mutational signatures found in bladder cancers?
We found that they can!

Structural diversity and conservation among CRESS-DNA bacilladnaviruses revealed through cryo-EM and computational modelling pubmed.ncbi.nlm.nih.gov/41327231/ #cryoEM

SBGrid webinars are hosted with partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis of Belmont University.… TomoNet

For our November software webinar we heard from Hui Wang from UCLA on TomoNet - Automatic Particle Picking of Flexible Lattice-Like Structures for CryoET.

If you missed it, you can watch it on SBGrid's YouTube channel:

buff.ly/gnhR2AV

#SBGrid #Webinars

GitHub - swing-research/icecream: 🍦Icecream: a self-supervised framework for cryo-ET reconstruction 🍦Icecream: a self-supervised framework for cryo-ET reconstruction - swing-research/icecream

We just released version v0.3.1 of 🍦Icecream!
Importantly, this fixes a bug in missing wedge correction. Please update, and let us know how it works for you!
#CryoET #TeamTomo

github.com/swing-resear...

Structural characterization of plum pox virus by cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/41326719/ #cryoEM

Ten years of the CCP-EM Spring Symposium pubmed.ncbi.nlm.nih.gov/41324471/ #cryoEM

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome!

Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

Honoured to be selected as one of this year’s EMBO Young Investigators!

Grateful to my team and colleagues for all their support, and excited about the opportunities this will create for my group and for our work in structural virology.

www.embo.org/press-releas...

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

Visualizing the translation landscape in human cells at high resolution pubmed.ncbi.nlm.nih.gov/41315256/ #cryoEM