Thelonevirologist

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2 SARS-CoV-2 is a positive-sense RNA virus and was responsible for the devastating COVID-19 pandemic. Although the current disease burden is less severe, there are limited treatment options, significant...

Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2 www.biorxiv.org/content/10.1...

At today’s parent-teacher conference our 8yo’s teacher told us that she was surprised that he not only can spell “ubiquitous” but also can use the word correctly in context. And that he reads books with 400 pages. We knew.

Protection from flu vaccine around 50% for Southern Hemisphere, data reveal

Protection from flu vaccine around 50% for Southern Hemisphere, data reveal www.cidrap.umn.edu/influenza-va...

Los Angeles County documents 2nd case of locally acquired clade 1 mpox The county announced the detection yesterday, and it involves an adult with no recent travel to mpox-endemic areas.

Los Angeles County documents 2nd case of locally acquired clade 1 mpox www.cidrap.umn.edu/mpox/los-ang...

Ebola virus in Kasai revives 50-year-old questions on viral latency On Sept 4, 2025, DR Congo declared its 16th Ebola virus outbreak. The epicentre of this outbreak occurred in the Kasai province—the first resurgence in this region since 2008.1 Genomic analysis identi...

Ebola virus in Kasai revives 50-year-old questions on viral latency www.thelancet.com/journals/lan...

Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding Author summary Recent epidemic-causing coronaviruses, including SARS-CoV-2, originated in bats. Large numbers of such viruses circulate in bats and pose clear and present risks to humans. However, our...

Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding

journals.plos.org/plospathogen...

The integrin protein ITGβ1 effectively suppresses porcine epidemic diarrhea virus replication through facilitating MDA5 oligomerization and subsequent activation of the type I interferon signaling pat... Porcine epidemic diarrhea virus (PEDV), an alpha coronavirus, severely impacts newborn piglets, leading to acute manifestations including vomiting, diarrhea, dehydration, and high mortality rates in s...

The integrin protein ITGβ1 effectively suppresses porcine epidemic diarrhea virus replication through facilitating MDA5 oligomerization and subsequent activation of the type I interferon signaling pathway journals.asm.org/doi/10.1128/...

Insights into Persistent SARS-CoV-2 Reservoirs in Chronic Long COVID

www.mdpi.com/1999-4915/17...

First locally acquired US case of more severe clade 1 mpox identified in California

First locally acquired US case of more severe clade 1 mpox identified in California www.cidrap.umn.edu/mpox/first-l...

On an Arctic archipelago, frozen soil may preserve a hidden history of viruses Scientists are hunting for ancient RNA in Svalbard’s permafrost, hoping to shed light on the evolution of viral diseases

On an Arctic archipelago, frozen soil may preserve a hidden history of viruses www.science.org/content/arti...

Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates - Nature Immunology The authors report that an AS03-adjuvanted chimeric hemagglutinin-based influenza vaccine induces persistent stalk-specific serum antibody and bone marrow plasma cell responses in nonhuman primates, o...

Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates

www.nature.com/articles/s41...

An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques Mucosal delivery of a rhesus adenovirus–vectored H5N1 influenza vaccine confers protection against lethal challenge in cynomolgus macaques.

An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques www.science.org/doi/10.1126/...

Ultrapotent human antibodies lock E protein dimers central region of diverse DENV3 morphological variants - Nature Communications Human antibodies DENV-290 and DENV-115 are ultrapotent against dengue virus 3 strains with differing particle morphologies. CryoEM shows both bind across two protomers at the center of the envelope pr...

Ultrapotent human antibodies lock E protein dimers central region of diverse DENV3 morphological variants

www.nature.com/articles/s41...

A replicating RNA vaccine protects against severe fever with thrombocytopenia syndrome virus infection in mice - npj Vaccines npj Vaccines - A replicating RNA vaccine protects against severe fever with thrombocytopenia syndrome virus infection in mice

A replicating RNA vaccine protects against severe fever with thrombocytopenia syndrome virus infection in mice

www.nature.com/articles/s41...

Three large turkey farms in Minnesota hit with H5N1 avian flu APHIS also notes several outbreaks in backyard flocks.

Three large turkey farms in Minnesota hit with H5N1 avian flu www.cidrap.umn.edu/avian-influe...

Viewpoint: We owe parents real data before we mess with kids' vaccination schedule

Viewpoint: We owe parents real data before we mess with kids' vaccination schedule www.cidrap.umn.edu/childhood-va...

Study finds no link between mRNA COVID vaccines early in pregnancy and birth defects

Study finds no link between mRNA COVID vaccines early in pregnancy and birth defects www.cidrap.umn.edu/covid-19/stu...

More measles in South Carolina as US nears 1,600 confirmed cases

More measles in South Carolina as US nears 1,600 confirmed cases www.cidrap.umn.edu/measles/more...

A vaccine central in A(H5) influenza antigenic space confers broad immunity - Nature A high-resolution antigenic map of influenza A(H5) haemagglutinin (HA) enables the design of immunogenic and antigenically central vaccine HA antigens that elicit antibody responses broadly covering t...

A vaccine central in A(H5) influenza antigenic space confers broad immunity

www.nature.com/articles/s41...

How my stutter is teaching me humility—in science and beyond “I will always face the burden of coaxing my body to do what comes naturally and effortlessly for most,” this assistant professor writes

How my stutter is teaching me humility—in science and beyond www.science.org/content/arti...

Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates

www.nature.com/articles/s41...

The free-living ciliate Tetrahymena pyriformis inactivates engulfed influenza A(H1N1)pdm09 virus via two distinct types of endosomes - Scientific Reports Scientific Reports - The free-living ciliate Tetrahymena pyriformis inactivates engulfed influenza A(H1N1)pdm09 virus via two distinct types of endosomes

The free-living ciliate Tetrahymena pyriformis inactivates engulfed influenza A(H1N1)pdm09 virus via two distinct types of endosomes

www.nature.com/articles/s41...

The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition - Nature Microbiology Viruses generally have compact genomes, resulting in many viral mRNAs with short 5’ untranslated regions. An antiviral complex exploits this feature of viral mRNAs to selectively inhibit viral protein...

The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition

www.nature.com/articles/s41...

Virion aggregation shapes infection dynamics and evolutionary potential | Journal of Virology A deeper understanding of the processes shaping viral evolution will advance our ability to anticipate viral emergence, escape from immune responses, and resistance to therapeutics. Although much is known about how genetic variation fuels viral evolution, how modes of viral spread influence the generation and structure of genetic variation remains poorly characterized. Here, we examine how the collective dissemination of viruses modulates early infection dynamics and viral diversity. We find that, although infection in groups reduces the number of independently infected cells, it results in a more genetically diverse progeny population, an outcome that may enhance evolutionary potential.

Virion aggregation shapes infection dynamics and evolutionary potential journals.asm.org/doi/10.1128/...

Galectin 3-binding protein suppresses PRRSV replication via Cullin3-mediated ubiquitination degradation of non-structural protein 12 | Journal of Virology Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major challenge to global swine production due to its genetic diversity, rapid mutation rate, and ability to evade host immunity. ...

Galectin 3-binding protein suppresses PRRSV replication via Cullin3-mediated ubiquitination degradation of non-structural protein 12 journals.asm.org/doi/10.1128/...

Report proposes new framework to prepare for future pandemics

Report proposes new framework to prepare for future pandemics www.cidrap.umn.edu/public-healt...

Mucosal Taï Forest virus infection causes disease in ferrets Author summary Filoviruses are zoonotic pathogens known to cause outbreaks of hemorrhagic disease in humans. Filovirus human-to-human transmission occurs via bodily fluids likely by exposure of mucosa...

Mucosal Taï Forest virus infection causes disease in ferrets

journals.plos.org/plospathogen...

Host cell Z-RNAs activate ZBP1 during virus infections

www.nature.com/articles/s41...

Central Zika virus infection causes hypothalamic inflammation and persistent insulin resistance in adult mice

www.nature.com/articles/s41...

Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses

www.nature.com/articles/s41...