Amir Toor

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T cell tolerant fraction as a predictor of graft-vs-host disease following allogeneic hematopoietic cell transplantation Background Donor T cell reconstitution following allogeneic hematopoietic cell transplantation (HCT) is crucial for protective immunity against infections and cancer relapse. However, its use remains ...

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B cells targeting parasites capture spatially linked antigens to secure T cell help Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.

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Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.

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Tumor Lysis Syndrome | NEJM Tumor lysis syndrome has evolved and become less predictable with the introduction of new cancer therapies. This review explores risk factors and causes of the syndrome, as well as strategies for t...

Tumor Lysis Syndrome | New England Journal of Medicine www.nejm.org/doi/full/10....

The IL-33 and IL-4Rα blocking antibodies itepekimab and dupilumab modulate both distinct and common inflammatory mediators in asthma | Science Translational Medicine www.science.org/doi/10.1126/...

Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.

Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine | Science Immunology www.science.org/doi/10.1126/...

Tumours might be sensitized to immune therapy by COVID mRNA vaccines COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.

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People with some cancers live longer after a COVID vaccine mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.

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Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

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Nobel Prize in Physics 2025 The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electri...

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New radioactive isotope therapies promise more targeted attacks on cancer Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies

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The immunology of brain tumors The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

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Adenosine 2A receptor–dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogramming Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.

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Design of a potent interleukin-21 mimic for cancer immunotherapy A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

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T-cell lymphopenia characterizes immunodeficiency in a broad spectrum of TBDs. buff.ly/6B7IlyR #hemesky

Newcastle University hopes to improve sepsis treatment nationwide Sepsis is treated by antibiotics but using the medication too much can lead to deadly superbugs.

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Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1 mTORC1 activation by components of a cytokine cocktail enhances NK cell cytotoxicity toward cancer cells.

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Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

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Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

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Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

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Depriving brain tumours of an amino acid could enhance chemotherapy Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.

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Newfound immune cell in mice hints at why inflammation spikes with old age Pathogen-consuming cells found in fat tissue also play a part in lipid balance.

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Here’s how the first proteins might have assembled, sparking life RNA could have helped amino acids join up without preexisting protein machinery, lab study suggests

New research offers a glimpse of how RNA might have helped form the first simple proteins—an event that could have set the stage for evolution. https://scim.ag/466Rkz0

Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

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First day of classes at @jhuartssciences.bsky.social. A glorious day to learn #QuantumMechanics!

I'm teaching two courses - QM for physics majors, and Philosophy of Cosmology for a general audience. I'm going to try to maintain a thread saying what happens in each class, let's see how I do.

Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy | NEJM A rare T-cell lymphoma after chimeric antigen receptor (CAR) T-cell therapy for myeloma was linked to CCR4 overexpression and vector integration, which highlights the need for monitoring after CAR ...

Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy | New England Journal of Medicine www.nejm.org/doi/full/10....

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...

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Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy Treg cells expressing a short FOXP3 isoform exhibit a TH-like cell phenotype with reduced suppressive function and mediate antitumor immunity.

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