@jeffsparks.bsky.social
Rheumatologist | Associate Professor of Medicine | @BrighamWomens | @harvardmed | Investigating rheumatoid arthritis susceptibility, RA-ILD, and outcomes | ⚡️⚡️
🆕 Collaboration with RheumNow 🔵
3-Part Series on Interstitial Lung Disease
Part 2: Diagnosis & Subtypes of #ILD
👩🏻⚕️ What to look for on Physical Exam
🧪 Serologic Testing & Diagnostic Workup
🫁 Differentiating ILD Subtypes on Imaging
#RheumSky #PulmSky #MedSky #InterstitialLungDisease
I updated website for The COVID–19 Global Rheumatology Alliance so that the full GRA curriculum vitae is on the main page: rheum-covid.org
11.08.2025 01:07 — 👍 2 🔁 2 💬 1 📌 0Happy to have compiled this review on the role of the intestinal mucosa in RA and SpA with my friends @kknoop.bsky.social, Joyce, Mario, and Kentaro.
We challenge the "leaky gut" hypothesis and why we shouldn't use that term that oversimplifies how our microbiome shapes immunity.
Alu expression in dermatomyositis muscle tissue
doi.org/10.1002/art....
Characterizing a cohort of patients with SpA spectrum disorders initially presenting as PMR
doi.org/10.1002/art....
Patients with RA-associated lung disease at increased risk of serious infection
doi.org/10.1002/art....
↓
and NIAMS!
31.05.2025 10:42 — 👍 2 🔁 0 💬 0 📌 0
ICYMI in our May issue—Survival in patients with rheumatoid #arthritis and recently diagnosed early-stage colorectal, lung, or prostate #cancer receiving TNF inhibitors bit.ly/3Q9Or8N
Plus, linked Comment by @jeffsparks.bsky.social & @nasingh.bsky.social bit.ly/42XQnsw
#Medsky #Rheumsky
EULAR/ACR risk stratification criteria (after simplification) for individuals with arthralgia at risk for rheumatoid arthritis, to be used in presence or absence of imaging
Figure 2. Predicted risks (graph) and test characteristics and predictive values for several score cutoffs (table) for the risk stratification criteria with- out or with imaging. Predicted risks for the sum scores obtained in Table 4. Test characteristics and predictive values for several cutoffs of risk scores are shown; an extensive list of cutoffs with test characteristics and data on the percentage of persons with these cutoffs is presented in Supplemental Table S8. The area under the curve of the criteria without imaging is 0.80 and with MRI data is 0.85. MRI, magnetic resonance imaging; NPV, negative predictive value; PPV, positive predictive value; RA, rheumatoid arthritis; Sens, sensitivity; Spec, specificity
EULAR/American College of Rheumatology Risk Stratification Criteria for Development of Rheumatoid Arthritis in the Risk Stage of Arthralgia
doi.org/10.1002/art....
Published simultaneously in Annals of Rheumatic Diseases
#Medsky #Rheumsky
⏰ It’s Today! 3:15, Charter 3
🗣️ BSR SARD-ILD Guidelines working group!
👋🏽 me - management
👋🏽 Muhammad Nisar - monitoring
👋🏽 Nazia Chaudari - screening
🪑 Clive Kelly @cliveryton
Come join us!! #ILD 🫁 🖐️!!
#BSR2025
Thank you to the #NephMadness Selection Committee members who helped us develop the teams in each region:
- @jordybc.bsky.social
- Mehmet Sever
- @thenestor.bsky.social
- @jeffsparks.bsky.social
- Mariana Murea
- @lawdishu.bsky.social
- Swee-Ling Levea
- Babak Orandi
- Susan Samuel
#NephMadness 2025 Champion: CAR-T for Autoimmune Diseases
bit.ly/NM25Champ
@nephrosparks.bsky.social @annaburgner.bsky.social @kidneywars.bsky.social @jrkott27.bsky.social @catochita.bsky.social
The final results of #RheumMadness 2025 are out!
Read more about the panel's choices on our website, plus our list of thank you-s to all our collaborators who make this possible!
sites.duke.edu/rheummadness/
Thank you all for another great year!
Research Article
Serum Biomarkers of Pulmonary Damage and Risk for Progression of Rheumatoid Arthritis–Associated Interstitial Lung Disease
📖 www.jrheum.org/cgi/content/...
@jeffsparks.bsky.social
#biologicalmarkers #rheumatoidarthritis #interstitiallungdisease
Never played #RheumMadness ?
Think you don't have enough time to submit your bracket?
Think again. Submit with two simple steps:
1. Watch the 2-minute explainer video below
2. Head over to the tournament website and submit a bracket (IT'S FREE)
26.5 hours left!
tourneytopia.com/RheumMadness...
Only 1.5 days left to submit your #RheumMadness bracket!
Next up on our countdown: SGCAPS + MSKUS prediction tool for #giantcellarteritis, by fellows from MCW.
Read it here:
sites.duke.edu/rheummadness...
Tolvaptan for hyponatremia was the first paper I ever summarized during journal club as a medical student! @nephrosparks.bsky.social
26.03.2025 01:34 — 👍 1 🔁 0 💬 0 📌 0Incredible honor to participate in this year's #NephMadness- the tournament my brother @nephrosparks.bsky.social helped found years ago
My commentary about basketball (#Razorbacks), brotherhood, and RheumOnc / CAR-T
Also make sure to participate in #RheumMadness- CAR-T team there too
#NephMadness 2025: CAR-T for Autoimmunity – Driving to the Championship
Any my brother getting involved this year !!!! @jeffsparks.bsky.social
ajkdblog.org/2025/03/21/n...
#NephMadness 2025: CAR-T for Autoimmunity – Driving to the Championship
Awesome to have the Sparks brothers in Nephmadness! @nephrosparks.bsky.social @jeffsparks.bsky.social
ajkdblog.org/2025/03/21/n...
#NephMadness 2025 Commentary by @jeffsparks.bsky.social:
CAR-T for Autoimmunity – Driving to the Championship
bit.ly/NM25SparksCo...
Patients with systemic autoimmune rheumatic diseases remain at risk for hospitalisation for COVID-19 infection in the Omicron era (2022–2024): a retrospective cohort study rmdopen.bmj.com/content/11/1...
14.03.2025 01:21 — 👍 3 🔁 2 💬 0 📌 0#RheumMadness + #NephMadness podcast is up!
CAR-T discussion starts at min 22:30
Find it here 👇
rheummadness.buzzsprout.com/1465681/epis...
@jeffsparks.bsky.social @nephmadness.bsky.social
one of those was on placebo though ?
12.03.2025 01:54 — 👍 2 🔁 0 💬 1 📌 0
#NephMadness 2025: The PodCrawl
buff.ly/p3xR3cg
Podcasts:
- @thecurbsiders.bsky.social
- Life as a Nephrology Professional @nkf-professionals.bsky.social
- GN in Ten
- @rheummadness.bsky.social
- @freelyfiltered.bsky.social
- Poison Lab
- Nephron Segment
- Kidney Chronicles
#NephMadness 2025: CAR-T for Kidney Disease Region
buff.ly/iEgImMW
Teams:
- CAR-T for Autoimmune Disease
- CAR-T Side Effects
Expert: @jeffsparks.bsky.social
Writer: Yara Mouawad
Execs: Dia Waguespack & @annaburgner.bsky.social
#NephMadness 2025 is here!!! ajkdblog.org/2025/03/01/w...
01.03.2025 12:16 — 👍 18 🔁 14 💬 0 📌 1
Our March issue is live!
Including research on #ILD in #RheumatoidArthritis and #SystemicSclerosis, cardiovascular protection in #gout, and the burden of #arthritis in Australia, plus much more! www.thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky
At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis!
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
