Kathrin Lang

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77

Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factor...

www.science.org/doi/10.1126/... le 🦠💫💫💫 #ribosome #rnasky

Structural basis for the ubiquitin chain recognition of the human 26S proteasome Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann
Let me walk you through it 🧵 1/9

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no toxicity towards human cells.

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

https://go.nature.com/4iECjJz

Wow!! Exciting news! Congrats Georg!! 🥳🤩🥂

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

Congrats abhishek and team!!

Optimized Directed Evolution of E. coli leucyl‐tRNA Synthetase adds many Noncanonical Amino Acids into the Eukaryotic Genetic Code Including Ornithine and Nϵ‐Acetyl‐Methyllysine The pyrrolysyl pair has dominated noncanonical amino acids (ncAAs) incorporation in eukaryotes, but additional engineerable pairs are needed to further expand this toolbox. Although E. coli leucyl-tR....

Elise and Tarah's work on engineering leucyl-tRNA synthetase to incorporate numerous ncAAs in mammalian cells now published! A bit of good news amidst these chaotic times onlinelibrary.wiley.com/doi/10.1002/...

📢 The Louis-Jeantet Foundation is happy to announce the 2025 #LouisJeantetPrizes, awarded to VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social and to GILLES LAURENT @ maxplanck.de

CONGRATULATIONS!!!

👉 jeantet.ch/en
👇 follow thread

table of contents graphic for review titled synthetic lipid biology

abstract of review article

Po-Hsun Brian Chen

Xiang-Ling (Julia) Li

Overjoyed and honestly relieved to share a Chem Rev magnum opus from Brian Chen & Julia Li titled Synthetic Lipid Biology! In it, we organize efforts across numerous fields to create, manipulate, and analyze lipids and biomembranes. Check it out! doi.org/10.1021/acs.... #lipidtime #chemsky #chembio

E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination

www.nature.com/articles/s41...

Engineering covalent small molecule–RNA complexes in living cells - Nature Chemical Biology Small-molecule ligands have been developed that covalently attach to their cognate RNA aptamers in vitro and in living cells. This strategy opens up new avenues for RNA imaging applications (for examp...

Exciting paper by the groups of Ronald Micura and Alexandra Lusser in @nchembio.bsky.social. Covalent binders to structured RNA based on alkyl halides and alkyl mesylates show engagement of the preQ1 and Pepper aptamers in vitro and in cells. www.nature.com/articles/s41...

Die Fachgruppe Biochemie der @gdch.bsky.social wünscht ein frohes neues Jahr!

Wir hatten ein großartiges 2024 mit einer fantastischen Biochemie-Tagung. Wenn Sie in 2024 eine herausragende Doktorarbeit oder Veröffentlichung in Ihrer Gruppe hatten, nominieren Sie für unseren Förderpreis!

Efficient circular RNA synthesis for potent rolling circle translation - Nature Biomedical Engineering Trans-splicing-based methods that are independent of bacterial sequences and that allow the incorporation of RNA modifications enable the reliable synthesis of circular RNAs and enhance the efficiency...

Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social!
www.nature.com/articles/s41...
#RNA #RNABiology #RNAsky #Translation #mRNA

WOW!!! Beautiful new Nature paper from Burkart Lab UCSD reveals how non-ribosomal peptide natural product synthetases work together.

They use tetrazine click chemistry to capture these huge protein complexes mid-reaction. 3 different snapshots show different states.

www.nature.com/articles/s41...

person in front of microscope and microscopy image

Curious what we do in my new lab at D-CHAB @ethzurich.bsky.social 🔬⚗️? Save the date for my inaugural lecture on April 3, 2025 and if you can’t wait to know more check out the news article and the associated video. chab.ethz.ch/en/news-and-...

Happy to see my Medicinal Chemistry and Chemical Biology Highlight out in the current CHIMIA and online. Thank you to @klanglab.bsky.social for the invitation!
www.chimia.ch/chimia/artic...

Thanks for contributing this highlight Nathalie!

First paper of our lab today @natureportfolio.bsky.social by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!

@embl.org #RNAbiology #RNASky

t.co/a24Xxcxdo0

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway https://www.biorxiv.org/content/10.1101/2024.11.21.623953v1 Ubiquitination is a fundamental and highly conserved protein post-translational modification pathway

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway https://www.biorxiv.org/content/10.1101/2024.11.21.623953v1

👋 +1 🙏☺️

Very creative use of a prebiotic-inspired, hybridization-accelerated covalent reaction for capture of charged aminoacyl-tRNAs.

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

Hi Bluesky! New here and a bit surprised not to see a starter pack dedicated to Chemical Biology so.. here we go!
go.bsky.app/DDpDuvo

Thanks!

Hi! I’d also happily join 😊

Professor of Synthetic Organic Chemistry and Professor of (Bio)Analytical Chemistry

🔈🔥! We have two open full professor positions at our institute (LOC) at ETH Zurich!
1. Synthetic Organic Chemistry
2. (Bio)analytical Chemistry

Amazing students, staff, colleagues, infrastructure, location and long-term perspectives.

🫵 Apply and be our colleague!!

ethz.ch/en/the-eth-z...