A color-tailored fluorogenic sensor for hydrogen peroxide Nature Chemical Biology - Hydrogen peroxide is a signaling molecule that can also cause damage if its levels are too high. Here, the authors report HyPerFLEX, a fluorescent sensor with tenable...

Check it out: rdcu.be/eLkJb

Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈 HyPerFLEX tracks cellular stress in real time, glows in multiple colours, works in low-oxygen environments, and could revolutionise research on aging, inflammation & disease!

4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...

Our first post on Bluesky!
1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins.
www.biorxiv.org/content/10.1...

Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!