RiemerLab @ UoCologne

Nice work together with the @jaelab.bsky.social on Fam136A as a novel Disulfide Relay substrate and guardian of proteostasis in the mitochondrial IMS - www.sciencedirect.com/science/arti.... Accompanied by a small graphical abstract…

Such an engaged community & pure excitement about organelles.
Fantastic days in Hyderabad with @riemerlab.bsky.social
#EMBOCCMB25 #EMBO

Interaction with AK2A links AIFM1 to cellular energy metabolism AIFM1 is crucial for mitochondrial function. Here, Rothemann, Pavlenko et al. show that AK2A interacts with NADH-dependent AIFM1 dimers. They demonstrate that this interaction stabilizes AIFM1 dimers and enhances their activity. Given the proximity to ADP/ATP translocases and ATP synthase, the AIFM1-AK2A complex may contribute to metabolic adaptation.

Interaction with AK2A links AIFM1 to cellular energy metabolism

Big Hurra for the first authors Alex and Egor. Published in Mol Cell, doi.org/10.1016/j.mo..., similar nice work from the rappsilber lab in the same issue. As usual accompanied by a small illustration

New work in a great team effort with the @poepsel-lab.bsky.social. We identified novel interactors of AIFM1 and found that this protein once only associated with cell death is a master organizer of the mito-IMS: By interaction with AK2 and SLC25 family members ensuring metabolic adaptation.

@dfg.de retreats are great, especially when they come with a foosball table with integrated shot glasses - best networking!

Cheers to that, SPP2453

@warscheidlab.bsky.social
@cmunch.bsky.social
@herrmannlab.bsky.social
@riemerlab.bsky.social
@jaelab.bsky.social

The evolving role of mitochondria in metabolism The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…

Join us at the EMBO/FEBS lecture course:
The evolving role of mitochondria in metabolism
14 – 18 September 2025 | Belgrade, Serbia:
meetings.embo.org/event/25-mit...

Great work by Konstantin!

A new tool from our lab :-). Together with the Brachvogel, Bogeski and Mielenz labs. We developed a genetically encoded sensor to monitor activity of the dipeptidases DPP8 and DPP9 in cells allowing us to ask fundamental questions about their spatiotemporal regulation. DOI: 10.26508/lsa.202403076

A new study from the @riemerlab.bsky.social and the bange lab. We found a new mode how specific degradation motifs become unmasked by DPP8/9. Really nice work by Kim, Konstantin and Franziska. As usual accompanied by a special graphical abstract. doi.org/10.1038/s443...

Monitoring subcellular NADP redox state with NAPstar biosensors

Monitoring subcellular NADP redox state with NAPstar biosensors @riemerlab.bsky.social @morganlab-saarland.bsky.social
@jan-oleniemeier.bsky.social

www.sciencedirect.com/science/arti...

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature Communications This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...

A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫

Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱

Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...

Again, glutathione comes to the rescue. In yeast, Tsa1 oxidizes glutathione at moderate H2O2 concentrations when the TRX system becomes inactivated by oxidation. A study together with the Morganlab and the Depontelab. doi.org/10.1016/j.fr...

We just published a study on the first endogenous cysteine-free interactor of the mitochondrial disulfide relay - HAX1. HAX1 relies on MIA40 for folding and stability and does not require the redox fxn of MIA40. Nice collaboration w/ #ulrichlab. doi.org/10.1111/febs...

This week, the @crc1678 kick-off retreat brought all the project leaders together! 🚀 A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! 💡👩‍🔬🧑‍🔬 #Research #Collaboration