BrownLab @Mt.Sinai

In IL-12.aFOLR2.CAR–treated tumors, cancer cells are closely juxtaposed with GZMB⁺ CD8⁺ T cells, consistent with antigen-dependent cytotoxic engagement. But that's not the only way the cancer cells die! To find out more, see the paper for full data, figures and the amazing co-authors!

This resulted in tumor control in models of disseminated ovarian and lung cancer, even though the CAR T cells were not targeting cancer cells.

At low dose and without prior lymphodepletion, this therapy triggered a profound resetting and reprogramming of the TME, with significant infiltration of endogenous CD8 T cells reactive to tumor cells and immunostimulatory CXCL9+ macrophages.

We describe IL-12–armored CAR T cells that target tumor-associated macrophages rather than cancer cells, by recognizing the tumor macrophage markers FOLR2 or TREM2. We show these CAR T cells both kill immunosuppressive tumor macrophages and localize IL-12 activity within the tumor microenvironment.

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth Tumor-associated macrophages (TAMs), which commonly express FOLR2 or TREM2, are enriched in solid tumors and keep the tumor microenvironment (TME) imm…

I am thrilled to announce that our latest paper is out now in @cp-cancercell.bsky.social! 1/n www.sciencedirect.com/science/arti...

New **RESOURCE** in @natcancer.nature.com - a landmark single-cell Immune Atlas of multiple myeloma—1.3M+ bone marrow cells from 337 patients. Led by the Immune Atlas Consortium with major contributions from Sacha Gnjatic, @edgargk.bsky.social & HIMC profiling teams 🧐 www.nature.com/articles/s43...

Statewide Town Hall to Fund New York Science Over the past year, we have been fighting back against attacks on science and higher education. While we’ve made progress, many of us continue to be deeply impacted by cuts to federal grants and the p...

📣 VIRTUAL TOWNHALL 📣

This Friday. Organized by NY-CURES & postdoc unions ✍️ >>> docs.google.com/forms/d/e/1F...

Find out how the proposed Empire Biomedical Research Institute can help solve issues NY State is grappling with: affordability, workforce stability and long-term health & economic growth.

A whimsical, vintage-style Christmas illustration shows Santa Claus flying in a sleigh over Albany, New York. Santa wears a vibrant blue-green suit with white fur trim and holds a scroll titled "This Year’s Nice List," featuring items like "New tools for prevention, diagnostics, and therapeutics" and "Supported postdocs and early-career scientists." His sleigh, shaded in coordinating tones of teal and blue-green, is overflowing with scientific lab equipment such as test tubes, microscopes, and conical tubes. Cheerful reindeer, each dressed in tiny white lab coats, pull the sleigh through a snowy, star-filled sky. Below, Albany’s Capitol buildings glow warmly amid a snowy landscape, completing the festive and science-themed scene.

New York’s research ecosystem delivered plenty of “nice list” rewards this year. Now we need Albany to deliver EBRI so we can keep that impact growing. Research is the gift that keeps on giving, so for a healthier and wealthier New Year for all New Yorkers, sign our letter to 🎅 >>> c.org/hwy54dWJDb

Need more info before signing petition for state-backed research institute? Get the full behind-the-scenes 🎞️ of how the Empire Biomedical Research Institute proposal came to be, what’s needed to move it forward, and how other states can follow suit: keypoint.keystonesymposia.org/home/shruti-...

NY medical schools press Gov. Hochul to put up billions for scientific research The request comes amid continuing uncertainty over federal funding, with research and thousands of jobs on the line.

🗞️ in @gothamist.com from @clewisreports.bsky.social.

Our 2 cents: EBRI doesn’t compete with other urgent needs — it equips NYS to meet them. Not funding it now worsens pressures; funding it grows the economy to help fix them.
State-backed research is a win-win-win-win. gothamist.com/news/ny-medi...

Natural killer cells in kidney immune surveillance, injury and fibrosis Nature Reviews Nephrology - This Review discusses the latest advances in natural killer cell biology, including insights into population heterogeneity, and examines the roles of these innate...

🚨 REVIEW 🚨

Amir Horowitz & Peter Heeger in @natrevneph.nature.com highlight how diverse NK cells in the kidney support immune surveillance but also drive injury in many diseases and contribute to transplant damage, with high-resolution profiling revealing new therapeutic targets. 🧐 rdcu.be/eUgor

Sign the Petition Support a New York State Biomedical Institute for a Healthier, More Affordable Future

Petition for a NY Biomedical Institute. This is a no-brainer to support science in NY, similar to programs in CA/TX.

www.change.org/p/support-a-...

Immunologists Push for State Biomedical Research Funding in New York - AAI News Dr. Shruti Naik is one of the immunologists in New York state behind NY-CURES, advocating for state investment in biomedical research.

Wondering why you should ✍ our petition? c.org/nDnRNSsVcq

In @aai.org, founder @drshrutinaik.bsky.social reveals why the coalition was formed, why NY needs a state-backed research institute, and how scientists should organize for systemic support — here and nationwide.
news.aai.org/2025/11/20/n...

Sign the Petition Support a New York State Biomedical Institute for a Healthier, More Affordable Future

Run a lab? Work in a lab? Wondering where your future research funding will come from?

New York has an unprecedented opportunity on the table — a bold proposal to supercharge biomedical research and innovation across the state.

👉 Sign the petition & share to help make it happen.: c.org/TDMy2H9JTW

a black and white photo of a man and a woman with the words there 's nothing you can 't do Alt: GIF of Jay-Z and Alicia Keys Empire State of Mind video with the words there 's nothing you can’t do

We’re in a proud, confident and ambitious Empire State of mind! If you believe in building a better and brighter tomorrow, hustle on over to sign and share the petition for an Empire Biomedical Research Institute to fuel the future and the people like you who power discovery. c.org/hwy54dWJDb

Sign the Petition Support a New York State Biomedical Institute for a Healthier, More Affordable Future

📢 SIGN & SHARE THE PETITION! 📢

New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

With co-authors Bram Teunissen & @yizhoudonglab.bsky.social, we dive into emerging ways to make LNPs more precise—from tuning their chemistry to reprogramming RNA expression and even controlling protein stability & localization >>> a road🗺️ for more intelligent delivery & broader applications ahead.

A major hurdle for next-gen LNPs? We still don’t have great tools to see where they go or what they do in vivo.

Tracking the nanoparticle, RNA cargo, and protein output in real time is key to designing smarter, more targeted systems.

Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level Nature Biomedical Engineering - This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic...

Our new review in @natbiomedeng.nature.com is out!
RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits.
free to read 🔗 rdcu.be/eLxGs

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.

Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.

Wondering what *exactly* we’re up to?

Our first coalition email is about to go out—introducing the statewide biomedical institute we’re proposing and how you can help power it forward THIS WEEK!

Sign up now so you don’t miss it: www.nycures.org/

New York Cures – NY-CURESNew York Cures Website NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.

From patient to scientist: Sergei German beat cancer thanks to clinical trials, inspiring him to leave his career in finance and drive research @nygenome.org

A NY statewide biomedical institute will make more incredible stories like his possible.

Help make this happen, sign up at www.nycures.org/

Scientists—let’s use our agency!

NY-CURES is championing a landmark statewide biomedical institute for New York, built to restore and grow science for all

Working FOR a brighter future gives us hope, purpose, and momentum.

Want to be part of it? Follow us + DM—we’ve got many ways to get involved.

New York Cures – NY-CURESNew York Cures Website NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.

The BIGGEST impact you can have with 1 minute today ⏱️

Add your name to show NY is ready for a statewide biomedical institute.

CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.

✍️ www.nycures.org/

YouTube video by Concordia A Conversation with New York Governor Kathy Hochul | 2025 Concordia Annual Summit

“States like New York have an opportunity to position ourselves as real leaders in so many different areas.” @governor.ny.gov

Like her, we believe NY is ready for revitalization—by launching a state-wide biomedical institute that boosts jobs, the economy & cures. www.youtube.com/watch?v=WVtF...

Behind every scientist is an army of workers who keep the biomedical research ecosystem running. Hear from these workers and how they contribute at www.nycures.org/ and SIGN UP to have your voice heard!

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...

🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...

Forbes Best Employers By State 2025 List - Best Companies To Work For Forbes ranks the best employers to work for in each state. Discover companies with great benefits, excellent workplace culture, and high employee satisfaction.

Research powerhouses 💪 in @forbes.com Best-in-State list with @roswellpark.bsky.social in NY top10 🏆.

Also listed: @stonybrooku.bsky.social @mskcancercenter.bsky.social @northwellhealth.bsky.social.

To keep more talent here we must invest statewide in biomedicine. www.forbes.com/lists/best-e...

Impact Across California – CIRM For two decades, CIRM has been at the forefront of regenerative medicine, funding over 100 clinical trials and building the infrastructure that drives innovation in stem cell and gene therapies.

New York leads in science & medicine but without state investment, we risk losing talent, cures, jobs, & billions in economic return.

Every $1 California invested in biomedical research returned $4 to the state economy. This isn’t just science—it’s smart economics: www.cirm.ca.gov/our-impact/