Jenny Sachweh

We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...

Congrats David!

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Course Offerings | Marine Biological Laboratory

🔬 Applications are now open!

Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.

➡️Apply today: go.mbl.edu/courses

Figure 1 from the preprint

Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️

www.biorxiv.org/content/10.1...
#teamtomo

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?

www.biorxiv.org/content/10.1...

Video by Vittorio Boscaro.

1/n

If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...

Thanks :)

How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!

Thanks Carolin!!

Thanks Iskander!

Thanks Tamas! Hope you’re doing well!

Special thanks from my side also to @sonjawelsch.bsky.social who keeps the electron microscopy facility @mpibp.bsky.social running!

Thanks to everyone involved: Mandy Börmel, Sven Klumpe (@svenklumpe.bsky.social), Anja Becker, Reiya Taniguchi, Marta Kubańska, Verena Pintschovius, Eva Kaindl, Jürgen Plitzko, Florian Wilfling (@wilflinglab.bsky.social),
Martin Beck (@becklab.bsky.social) and Bernhard Hampölz!

The small GTPase Ran defines nuclear pore complex asymmetry Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

At EMBL Grenoble, lead an independent research group using bold, original approaches to integrate complementary structural biology methods with emerging nano X-ray imaging technologies, bridging scales and modalities to unravel molecular mechanisms.

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

The Molecular Systems Biology Unit is looking for an independent research group leader in one of many different areas from integrative structural biology to synthetic biology, and from AI-driven approaches to engineering biological systems.

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...

The MPG is advertising directorships - powerful positions for which recruitment is usually started by them reaching out to potential candidates. Let’s hope this open call will get some great (but maybe overlooked) scientists on the candidate list and doesn’t accidentally select for oversized egos…

It's fun to let the angle t run though the whole range and M_xy = M_z = n_s is the only spot that doesn't change - same mag for all spatial frequencies!

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!

Beautiful cutting-edge in situ cryoET work (with very pretty figures) from the Grange lab!

Great to see how the field is getting closer to doing structural work in tissues and how development in FIB technology, lift-out procedures, and correlative light microscopy contribute!

Hey optical tech dev folks: how do you do alignment? Can you outline your alignment procedures for positioning optics and verifying their correct positioning?

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps https://www.biorxiv.org/content/10.1101/2025.05.27.656403v1

A cityscape at twilight, from the middle of a street.

1. Can you figure out where I was standing when I took this picture?

ChatGPT could. Given the photograph (scrubbed of all header information), the new chain of thought model, ChatGPT o.3, was able to pinpoint the location with a few meters.

Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures | PNAS The physical limit in determining the atomic structure of biological molecules is radiation damage. In electron cryomicroscopy, there have been num...

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...

Using the 'right tool for the job'. It's not fashionable, but a powerful and often underappreciated approach...

-> Here's the yeast lifespan machine. Just a simple microscope with incubation, but full control over the hardware & software produced an excellent data platform!

doi.org/10.1101/2022...

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...