Pranav NM Shah

If we dont put in place checks and balances purpose built for our times we condemn ourselves to this morass and i would go so far as to say we would then deserve that fate.

Anything can work, the real question is whether the will to entertain, implement, adopt radical ideas exists within the community. While knowledge has been irredeemably commoditised on our collective watch, is there anything we can do to prevent its enshittification?

Caveolins are conserved (metazoan) proteins essential for forming membrane-derived vesicles called caveolae.

While evolutionarily distant caveolins have similar structures, we found they do not maintain caveolae-generating capabilities (movie).

What determines this? Check out our new preprint!

Check out this cool thread on the latest preprint by Gaurav Kumar, @james-r-barrett.bsky.social, @phaips.vd.st from our lab and colleagues, dissecting the physics of Rubisco condensates!

You're in for some stunning #cryoET of the pyrenoid - in Chlamy, of course 😉

Congrats to all involved!

Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others!

Apply!

Amazing!!

i updated my binaries just a couple of weeks ago... currently using `5.1.0-52aa4815`

Interesting… i’ve never had issues… but now i might have jinxed it 🙊

Launch relion w/o the —tomo flag and process as if it were an SPA dataset…

I am using 3d warp corrected subtomos… these work w/o issues and i believe that part of the code base hasnt changed since v3.0…

In that case switch to 3d… not had any significant issues processing data that way…

Using 2d or 3d inputs?

Recovery of infectious recombinant human norovirus using zebrafish embryos | PNAS www.pnas.org/doi/abs/10.1...

GenBio DTP Optional supporting text

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!

My exact same thoughts 🙈

It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.

#virology #cryoEM

go.bsky.app/Qxv95BL

ProteinCHAOS runs entirely in the browser and lets you choose how to visualize your protein structures.
It supports PDB files from the PDB and AlphaFold servers and offers several visual themes so you can "paint" abstract art with protein traces. I hope it helps you create some interesting images!

A particular highlight was to be able to see a bose-einstein condensate in Jorg Schmidmeyers lab at TU Wien.

10 days and 4 Uni’s later, happy to be back in Oxford with a head full of ideas! Thanks once again @danielhurdiss.bsky.social, Panagiotis Kastritis, @schurlab.bsky.social and Pradyumna Paranjape for hosting me! Enjoyed discussing science with you and your colleagues and lab members!

Spent my childhood in my G’Pa’s chem lab, loved birds then photography and the photography of viruses. Been capturing virus images since 2010 and across 3 continents.

Scientific journals: we don’t want you using generative AI because it makes shit up.

Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote

Same journal: AI cover art which makes no sense? Oooh!

Insightful!

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

Thank you for hosting me @danielhurdiss.bsky.social at @utrechtvirology.bsky.social! It was wonderful to visit and spend time with the members of the group. Until next time!

MPI-WIS postdoc application Max-Planck–Weizmann Postdoc (4-year, co-mentored) Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using recombinant pr...

MPI–Weizmann Postdoc (4-year, co-mentored)
Together with Ori Avinoam (Weizmann), we’re recruiting a postdoc to uncover membrane remodelling mechanisms in muscle development using cryo-EM of recombinant proteins, and cell imaging/CLEM. Apply here by 21.11.25 forms.gle/ZtDWUjcTBu4d...

Dont worry… clouds were very much in the way 😔

"The result is a treadmill of constant activity with
limited progress whereas core scholarly practices – such as reading, reflecting and engaging with others’ contributions – is de-prioritized."
arxiv.org/pdf/2511.04820
Will the real scientists please stand up?

Whelp! Just saw this @builab.bsky.social ! Yes please give it a go and let me know if you have trouble using it.