Barun Pradhan

Very excited to share my Phd/early post-doc work, out now in Cancer Research! Using multiomic data from multi-site tumors from ovarian cancer patients, we show that the tumors continue to acquire LINE-1 insertions after metastatic spread and find determinants of LINE-1 permissivity in this disease.

🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.

Nineteen killed in Nepal in 'Gen Z' protest over social media ban, corruption At least 19 people in two cities died on Monday in Nepal's worst unrest in decades, authorities said, as police in the capital fired tear gas and rubber bullets at protesters trying to storm parliament in anger at a social media shutdown and corruption.

If you haven't seen the news yet, the government of Nepal and the prime minister of Nepal murdered over 19 kids, some in school uniforms, and a kid that was 8 years old...just because they were protesting against their corruption and incompetence! #KPOli #Nepal www.reuters.com/business/med...

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules Distinguishing real biological variation in the form of single-nucleotide variants (SNVs) from errors is a major challenge for genome sequencing technologies. This is particularly true in settings whe...

Highly accurate sequencing OR high throughput? We refuse to choose.

Introducing ppmSeq, a method built to deliver both. Our latest from the @landau.bsky.social lab with Ultima Genomics
👀👀👀

See ⬇️ for a primer on the next frontier of genomics
www.biorxiv.org/content/10.1...

Had great fun hearing about it as you were developing it. Great to see this work out! Congrats Alex, Dan and the team!

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling Nature Methods - This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫
@landau.bsky.social

Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb

I'm looking for a postdoc to join my fantastic team at the NIH in Bethesda, MD. Great resources. Competitive salary. www.training.nih.gov/jobs/pdf-mb-...

Congratulations Ivan, Jackie and the team. Excited to read this up!

Single-cell mapping of regulatory DNA:Protein interactions Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics

This is so cool!! Looking forward to this being available in NEB shelves. Kudos to the team!!

Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder

@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔

Excited to share this new publication where we did a comprehensive analysis of standard (short-read) 10x single-cell RNAseq data to show that the locus-specific expression of LINE-1s can be detected based on the transcriptional readthrough. rdcu.be/dzrSl