Luke Jostins-Dean

I have been saying this for years:

There is nothing inherently progressive about emphasizing environmental causes over genetic ones.

Bad speculation about environmental causes can also be dangerous.

I wish, though, that the current administration hadn’t illustrated my point so spectacularly.

This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠

Filtering parquet files with dplyr GitHub Gist: instantly share code, notes, and snippets.

Parquet works really well with R as well. I use it all the time to work with GWAS summary statistics that won't fit into memory (our latest metabolite GWAS tested 95M+ variants in UKBB). Here's a minimal example of how to filter data on the fly while reading into R: gist.github.com/kauralasoo/f...

🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics

TIHYLTTW is just too perfect a name to give up, even if it makes it less marketable. One of my all-time favourite book titles.

Novartis & Roche collaborated w/ Oxford researchers at the Big Data Institute 2 develop AI model using largest collection of clinical trial data (Novartis-Oxford MS dataset) from >8000 ppl living w/ multiple sclerosis (MS) to reclassify the progression of MS www.ndm.ox.ac.uk/news/using-a... #biosky

Significant after correcting for 0.98 tests

Both of these guys talk very directly to my heart

Call to ban ‘intolerant’ child-free resorts and hotels in France Debate grows as Senator Laurence Rossignol says ‘we can’t organise society by separating children off’

Both sides of this debate made me feel very warmly about the people of France. www.theguardian.com/society/2025...

Welcome to our webinar “Multi-omic insights into human disease” by @jeffbarrett.eu on 4 September at 3 p.m. CEST!

Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease.

Learn more and sign up: www.lyyti.fi/reg/multiomi...

A true *history of Britain

The first seems to be 18th century, marked by Hume and Gibbon treating the legends as myths built upon a real minor local figure. The second, generally believing that Arthur was entirely fictional (or a broad composite of people) is much more recent (our lifetimes).

Nicholas Higham has a book that tries to answer that ("King Arthur. Myth-Making and History"). There are basically two stages: when did people stop believing the Arthurian romances were a true historian of Britain, and when did people stop believing Arthur was likely to be a real person at all.

It's a great book but I don't recall it having anything in particular about when people stopped believing in the truth of the Arthurian legends.

Amazing news! Excited to be part of this new direction of research.

Nice to see evidence we didn't just dream all these loci up.

The link from MAML2 notch signalling in DCs to systemic IL12/23 levels is interesting. Any idea what MAML2 is doing in DCs? I think most of the work to date has been in salivary glands (where MAML2 somatic mutations drive cancer).

@bradleyomics.bsky.social great work guys, well done

🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!

To see which of these underpin susceptibility, we colocalised these with IBD GWAS. Remarkably, we nominate effector genes at an enormous 74 (❗) loci where one has not previously been nominated in @OpenTargets. This therefore SUBSTANTIALLY improves on previous efforts. 10/

Postdoctoral Researcher in Single-Cell Genomics through the NORPOD program Postdoctoral Researcher in Single-Cell Genomics through the NORPOD program

Job alert ‼️ @thomasdwkim.bsky.social and I are recruiting a postdoc in single-cell genomics via the NORPOD program of the @nordicembl.bsky.social. Collaboration between @fimm-uh.bsky.social and @dandrite.bsky.social on multimodal data integration in neurodevelopment.
jobs.helsinki.fi/job/Helsinki...

My 7-year-old just made a knife out of Lego, and did this:

"I have a knife!"

*Does a few slashes, then poses in a fighting stance"

"and I am going to a gun fight"

Is this from something, or did he make it up himself?

Postdoctoral Fellow - Lee Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Lee Lab Reports to: James Lee [C] Closing Date: 23.59 GMT Job Description: Job titl...

📢 📢Job alert!📢📢
We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk‬. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk

I should probably say, just to be clear, that Nightingale Health Plc does not recommend eating 15 grams of butter on your slice of bread. There are likely to be negative effects on your health if done frequently, and you also just feel sort of oily afterwards.

If you are interested to know why I have been weighing out 15 grams of butter for my bread, and what it has to do with the metabolomics of aging, sign up to this webinar tomorrow

📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST.

Sign up: www.lyyti.fi/reg/aging_we...

FIMM-EMBL Group Leaders in Molecular Medicine FIMM-EMBL Group Leaders in Molecular Medicine

We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n

NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.

If anyone has a spare £1m plz DM

RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences

Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...

Goodbye #ESHG2025 and goodbye Milano! A great conference and a lovely city.

Some words of comfort for US scientists: "these are dark times, but we will absolutely rebuild". But until then, there are positions open for scientists in the more favourable "political and meteorological climate" of Australia (contact @dgmacarthur.bsky.social for details) #ESHG2025