Yaw Shin

Cracking the Code: Nucleic Acid Medicines Coming of Age The 2025 conference brings together leading academics and industry professionals to explore developments and challenges in the rapidly evolving field of nucleic acid medicines. By uniting researchers ...

Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...

Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes

How a tick-borne virus enters human cells Tick-borne encephalitis virus can infect the nervous system and cause life-threatening illness. Finding the cellular gateway it uses could transform prevention and treatment.

Finding the tick-borne encephalitis cellular gateway could transform prevention and treatment

go.nature.com/3Kqp5E9

How a dangerous tick-borne virus sneaks into the brain Hear the biggest stories from the world of science | 24 September 2025

This week on the pod:

🧠 New insights into tick-borne encephalitis
🔬 How might cancelled NIH grants affect the future of US science?
go.nature.com/42IRtrn

Ebola outbreak in the Democratic Republic of Congo is a warning “Ebola is never just a virus; it is a mirror,” writes infectious disease physician Krutika Kuppalli.

Ebola outbreak in the Democratic Republic of Congo is a warning
-by @krutikakuppalli.bsky.social

www.statnews.com/2025/09/11/e...

Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations Tenthorey et al. compare the effects of missense and indel mutations on the acquisition of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find that single indel mutations al...

Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.

www.cell.com/cell-genomic...

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.

Enables ‘watching’ of RNP assemblies inside living cells

Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...

Awesome Power of Genetic Screening! Honored to be part of this wonderful discovery—MFSD6 is an entry receptor for Enterovirus D68!

Once upon a time, in the late 1800s, people in Japan got really into breeding mice.

Coloured mice. Patterned mice. Even mice that danced.

They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study.

2/n

Today's @usatoday.com front page
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable

A nucleosome switch primes hepatitis B virus infection A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social

From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵

www.cell.com/cell/fulltex...

Congrats, Priya!

Check out our web tool for searching for interactors of your favorite cell surface protein, developed by undergrad Pinyu Liao and postdoc postdoc Brendan Floyd @stanford-chemh.bsky.social

cellsurfacemap.org

Graduate student admissions paused and cut back as universities react to Trump orders on research — STAT Acceptances for biomedical graduate students and postdoctoral scholars are being cut back at some universities and medical centers across the country as many grapple with the potential impact of the T...

Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT

apple.news/APlQhGHRrSfy...

Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses

www.pnas.org/doi/10.1073/...

Presented our #Henipavirus works at the #Hendra@30 meeting in Geelong, Victoria, Australia. Wonderful conference! Bonus—get to meet and know fellow Malaysian virologists/microbiologists!

Constructive Critics: Development's approach to peer review We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...

New @dev-journal.bsky.social editorial

We know we have high standards - but we're committed to making publishing with us constructive

From clear revision guidance to limitations sections & transparent peer review, we're here to help you share your science

journals.biologists.com/dev/article/...

Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!

go.bsky.app/SinqoJU

Viral susceptibility and innate immune competency of Carollia perspicillata bat cells produced for virological studies Multiple viruses that are highly pathogenic in humans are known to have evolved in bats. How bats tolerate infection with these viruses, however, is poorly understood. As viruses engage in a wide rang...

Anybody studying bat viruses and immunology knows there aren’t enough publicly available resources. You can only buy 3 bat cell lines at the moment and they aren’t suitable for many viruses. The first bat cell line was deposited with ATCC in 1967, btw.

Link: tinyurl.com/53nvxkyx

A review of virus host factor discovery using CRISPR screening | mBio All viruses depend on host cell machinery to complete their infection cycle for their survival. The intricate interactions between viruses and their host cells are not one-way processes. Hosts have co...

A review of virus host factor discovery using CRISPR screening

journals.asm.org/doi/10.1128/...