Ed Campbell

Cutting the NIH—The $8 Trillion Health Care Catastrophe This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

JAMA Forum on the proposed NIH budget…

jamanetwork.com/journals/jam...

I have institutional access myself, but in the bigger picture, I think this should be easily accessible to John Q Public, so they know the situation.

@nature.com Nice reporting, but you can’t pull the paywall on something like this?

Great article by a friend and amazing scientist

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.

Most inflammasome mutations in humans are gain of function, which complicates the question of why we have these molecular machines. @sunnyshinlab.bsky.social et al provide strong evidence that we need inflammasomes to prevent Salmonella infection. A must read! elifesciences.org/articles/90107

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

#MustRead. For #TumorImminologyLovers & more, check this fantastic review @ostunilab.bsky.social &co @cp-trendsimmuno.bsky.social all about #IL1 from #macrophages & pathogenic #inflammation in #cancer. #ScienceMatters dlvr.it/TJslPb

New survey data out from Navigator research shows the profound public concern and anger over the cuts in the Musk wilding spree. Unsurprisingly, voters are more concerned than almost anything by Trump and Musk shutting down cancer cure research (and research into cures for other diseases) in the U.S. 71% of independents says they're concerned or very concerned about it. 65% percent of voters over all. It's also something they've heard the least about. Here's the raw data for the poll and a powerpoint. And here's the chart on Elon and the billionaires. "Dangerous," "Power-Hungry," "Corrupt," and "Self-Serving" Are Best Descriptors of Musk and Other Billionaires' Actions Independents see them most as "dangerous," the job he is doing ao say they da greedy Oligarchic. American and inexpariEnced est lower across the body approve of * and "inexperienced" test lower across the board. Which of the following words or phrases best describes the actions of Elon Musk and the other billionaires working with the Trump administration? 2024 Trump Voters* Dem Rep Not-Strong Approvers Strong Approvers Dangerous 134% Power-hungry 134 Corrupt 131 Self-serving Greedy 129 MAGA Unaccountable Unelected 119 illegal Right-wing extremist Out-of-touch 115 114 Inexperienced Un-American IK Oligarchic Ik For more info, visit navigatorresearch.org n

ICYMI (especially if you work in Democratic politics):

Cutting cancer research is one of the things Americans are most worried about.

And one of the things they’ve heard the least about. According to polls from @navigatorsurvey.bsky.social:
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A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD) npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)

Results from our AntiRetroviral Therapy for Alzheimer's Disease (ART-AD) clinical trial are available online today and will be included in the inaugural issue of npj Dementia.

rdcu.be/edfwq

Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

Also picked up K-8 sleepovers on the regular when parents decided they were desperate for some normalcy

I ran saliva testing for schools in that time. It’s weird that surveillance testing did things like pick up whole hockey teams at once, or identified huge swaths of kids that attended a John Hues style house party in the midst of the pandemic, since young people aren’t spreaders.

Hopefully councils will follow. If they don’t, review is pretty useless. If they do, well then let’s hope those councils can move like our research lives depend on them, because they might. When a new budget/CR is passed, who knows what it will look like for research in America

Love these scraping tools. David O’Connor at UW has developed similar for both NIH reporter and study sections. I’m worried you guys will make them stop publishing these data but until then, shine the light!

github.com/dhoconno/rep...

Sounds like there is actually a limit of 50 FR additions this council round, despite their being 170 standing study sections. Who’s gonna get chosen? If you are on a standing study section and need a SEP to review your grant, I might not feel great.

Amazing scientist I got the chance to meet with during a seminar at UW. Recall the inspired conversation and questions to this day

Same directional trend for dems I’m sure, but happy to bet a steak dinner there is a larger slope for republicans in each case, related to conservative media influence.

Will the NIH science policy and grant funding be based on germ theory? Will miasma theory, a germ theory alternative, be used to dictate science policy or funding of any sort?

It was a mistake to fire the Nights Watch and tear down the wall in the deuchiest way possible. The 20 year old intern didn’t know the white walkers were real. We just assumed the wall and the watch were big government bloat. We are rebuilding the wall. Thank you for your grace and patience

It’s not unusual, or so I’ve been told 🤮

In terms of impact, scale and timeframe, a historic scientific accomplishment. If Trump bragged about this, I would just have to nod. Yet he doesn’t, and brags about fake or manufactured nonsense every day. We are living in the upside down

We might soon need your support to continue Illinois’ in biomedical research if the federal government decides to abandon the greatest biomedical research (and training) engine in the history of the world.

It’s very tough because graduate student and postdoc stipends are already a contentious point. They are underpaid for their expertise level. Grants are so carefully budgeted and salary such a big percentage, you have no money for supplies etc if you cut 30%. Or you fire 1 of 1 or 2 staff?

Nailed it….I hope she spiked the ball

NAS-receives their funding from….the federal government. It’s also my understanding members received an email with the punchline “don’t be too loud” but I certainly wasn’t on the mailing list and didn’t see the email

Good summary of what’s at stake with these NIH funding cuts here

Congrats on achieving a level of research funding that the folks in power are trying to make financially ruinous. Quick take a selfie from the mountaintop

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How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

This is the most relevant article to NIH and research cuts I’ve seen.

Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”

globalnews.ca/news/9793403...

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In a sea of hand-ringers, tantrums, middle-grounders and a tsunami of thread based explanations of indirect costs, @jkagan1.bsky.social is slaying….tip of the hat sir