Keshav K Singh, PhD

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...

A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...

YouTube video by NDTV Nick Booker Explains How Ancient India Made Artificial Intelligence Possible | NDTV World Summit

Nick Booker explains how ancient India paved the way for AI development

Also, watch youtu.be/0fSV3hEuyNA?....

youtu.be/-_ieOAzgHco?...

Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer - Nature Communications In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondr...

A new collection of papers related to #mitochondrialdisease from #week44! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer
www.nature.com/articles/s41...

The mystery of why leaves change colour in the autumn Although the chemistry of autumn colours is well understood, there is an ongoing debate among scientists about why trees evolved their vivid autumn colours in the first place.

Discovering Nature's Canvas: Exploring the Science Behind the Color Change in Leaves During the Autumn Season

www.bbc.com/future/artic...

Changes are coming to the NIH Biographical Sketch.

History Smelled. Here’s How We’re Sniffing It Out How can reconstructing long-lost smells of ancient artifacts help us connect with the past?

"The past often gets presented to us as odorless. But that overlooks the huge roll smell likely played in many historical realities..." 🧪 www.scientificamerican.com/article/how-...

Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...

Great collections of papers on #mitochondrialdisease from #week42 and #week43! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...

Happy Diwali-The Festival of Lights
As we celebrate this beautiful festival that
symbolizes the triumph of light over darkness, knowledge over ignorance, and good over evil - let us rekindle the light within us to create a brighter future for all.

#Diwali #diwalicelebration #deepavali

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

Delighted to participate in the exciting
symposium on "Artificial Intelligence in
Mitochondrial Medicine: emerging tools for diagnosis and monitoring

Hotel Galilei
January 23rd,2026
Pisa,Italy

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!

Hong et al, Cryo-EM structure of the prohibitin complex in open conformation https://www.pnas.org/doi/10.1073/pnas.2512430122

To honour the #MitochondrialDisease #AwarenessWeek 💚 we bring a new collection of recently-published research papers related to mitochondrial disease:
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Cryo-EM of the prohibitin complex

Tonight, shine a light of hope in green to support the mito community.

This week (Sept 15 to 21, 2025) is Mitochondrial Disease Week
-a chance to shine light on mitochondrial disorders and the people living with them.
Light up green for mito on 20th, September.

💚 September 15–21 is Mitochondrial Disease Awareness Week—a time to spotlight rare but serious conditions that affect the body’s energy “powerhouses.” Let’s stand with the mito community and help raise awareness for patients, families, and research.
#MitochondrialDisease #Awareness #Health

The amazing mitodancer! The real mito energy! 😂😂

Olahova et al, RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis

Wonderful selections of papers on #MitochondrialDisease from #week35 and #week36! 📚

biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

RTN4IP1 required for the final stages of mito CI assembly and CoQ synthesis

Stay calm and research on. 😂😂

💚 September 15–21 is Mitochondrial Disease Awareness Week-a time to spotlight diseases that are primarily due to defect(s)in mitochondria. Let’s stand with the mito community and help raise awareness for patients, families, and research.
#MitochondrialDisease #Awareness #HealthAdvocacy

Last two weeks of literature relevant for #MitochondrialDisease! 📚

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Please browse the collections here! 👇
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

Frontiers | Pathogenic synergy: dysfunctional mitochondria and neuroinflammation in neurodegenerative diseases associated with aging The term “neurodegenerative diseases” (NDDs) refers to a range of aging-associated conditions, including Alzheimer’s disease, Parkinson’s disease, and amyotr...

Faulty mitochondria don’t just sap energy—they spark brain inflammation. Together, they fuel Alzheimer’s, Parkinson’s & ALS. Our new article in Frontiers in Aging explains.

#Neuroscience #Aging #Neuroinflammation #Mitochondria #FrontiersInAging

www.frontiersin.org/journals/agi...

Marutani et al, Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease https://www.nature.com/articles/s41593-025-02010-4

#MitochondrialDisease collection of papers from #week32! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Highlights

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease

Join us in India for an exciting meeting on mitochondria in health, disease, and aging, Oct 9 to 11, 2025, at Manipal University, Manipal.

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction - Nature Metabolism CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and ...

Wonderful selection of papers on #MitochondrialDisease from #week31!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below, many more inside!
www.nature.com/articles/s42...

If I may put on my ex-academic hat today, I have a new peer-reviewed article out in the J of Mediterranean Archaeology! We did an mtDNA analysis of people buried at Gabii over the span of about a millennium. 🏺🧪