Thomas Gregor

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1

Catch up on our recent Community Lecture with Blaise Agüera y Arcas! The lecture, Computing, Life, and Intelligence, is available on SFI’s YouTube channel: www.youtube.com/live/75PAyV8...

@blaiseaguera.bsky.social

In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...

Ha! The same goes for peer reviewing somebody else’s manuscript: days not hours…

In preprints: exploring developmental robustness and timing with gastruloids How developmental processes are coordinated in time and space to ensure the robust formation of complex, functional patterns during embryogenesis remains an outstanding question. Investigating this in...

Check out our "In Preprints" @dev-journal.bsky.social w/ Yonit Maroudas-Sacks & Marc Trani Bustos @mpi-cbg.de @poldresden.bsky.social, putting recent #gastruloid work from @viktri08.bsky.social @thomasgregor.bsky.social @amartinezarias.bsky.social labs in broader perspective: doi.org/10.1242/dev....

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

It is also good to get some perspective, such as given by ballpark numbers and recent policies, since announcements were made. With the help of Perplexity. (1) The two systems start on different scales:

😱 A very hungry #PacManoid ate the original post 🍬🍬🍬

Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!

Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...

Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social

Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...

A methodology to reduce the localization error in multi-loci microscopy provides new insights into enhancer biology https://www.biorxiv.org/content/10.1101/2025.04.05.647393v1

The Standard Cosmology Model May Be Breaking Measurements of millions of galaxies suggest that dark energy changes over time and is more complicated than previously thought.

The Dark Energy Spectroscopic Instrument (DESI) has determined the distances to enough galaxies by now to conclude that the cosmological constant is not in fact constant.

Martino Ugolini and I wrote a review on how useful embryos are to understand the role of transcription bodies in gene expression. I am sure
@mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....

Fast & Fair peer review A new initiative offering high-quality peer review within 7 working days of submission Biology Open

We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL

Large-scale control over collective cell migration using light-activated epidermal growth factor receptors Programmable control over tissue movement is a fundamental challenge for tissue engineering and wound healing. Suh, Thornton, et al. discovered that a light-controlled EGF receptor controls long-range...

I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.

Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.

still possible to apply:
phygenome.sciencesconf.org

⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.

N2B27 media formulations influence gastruloid development https://www.biorxiv.org/content/10.1101/2025.03.15.643474v1

There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com

Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper.

www.cell.com/cell-systems...

John Reinitz, systems biologist, 1958-2025 Reinitz helped pioneer a data-driven, systems approach to developmental biology that is now widely used in the field today.

Shocking: a pioneer in quantitative developmental biology passed... one of my all-time heroes! He had a dominant influence on many in the early 2000s when this field started to take off. What a loss!

Obituary written by two of his former students:
biologicalsciences.uchicago.edu/news/john-re...

January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1...
#NotInTheGenes #InNumbersWeTrust

Check out this new paper from @thomasgregor.bsky.social 's lab on hydrogel embedding of mouse gastruloids to control gene expression and patterning.

Does anyone know of a search engine which searches all preprint archives, and only preprint archives (i.e., not Google Scholar)? In @europepmc.bsky.social I find @biorxivpreprint.bsky.social and EcoEvoRxiv , but not arXiv-Qbio.

Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!

Institut Pasteur decides to leave X The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of Molecular Cell that gene expression levels…

Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...

Dimitra and I had the pleasure to write a Preview:
www.sciencedirect.com/science/arti...

Self-generated gradients guide collective cell movement -but often different cell types must move together, e.g. in immune response.

We develop a theory of self-generated chemotaxis in mixed populations -are there optimal principles for this cooperation?🤔
www.biorxiv.org/content/10.1...