Karim Majzoub

PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.

STING and PiPs !

All you want for christmas is.... transposon mutagenesis!

Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team.

Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)

Nice Nice, @raflynn5.bsky.social Lab is unstoppable !

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women’s fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...

Endogenous retroviruses, RNA and human development !

Done

Sure, done

Well , the helper virus is not really known yet , we couldnt identify any other viral sequence in the same RNA sequence data set . So the question of the helper virus is still open in the fat-tailed dunnart :)

@samjwilsonphd.bsky.social we should update you on Zoe’s main project ! It has lately advanced considerably, we have a nice story in the making :)

Well , the helper virus is not really known yet , we couldnt identify any other viral sequence in the same RNA sequence data set . So the question of the helper virus is still open in the fat-tailed dunnart :)

A replication-competent deltavirus from the marsupial fat-tailed dunnart Sminthopsis crassicaudata Deltaviruses are circular, negative-sense RNA agents that replicate autonomously but depend on heterologous envelope glycoproteins for spread. Only partial sequences of deltaviruses had been reported ...

Zoe Denis a PhD student in our lab , describing the first marsupial deltavirus ! :)

A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

TimeVaults record cellular transcriptomes

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Bacteriophage genome-wide transposon mutagenesis Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward genetics has defined essential gen...

Kudos @jbdsf.bsky.social and team for this beautiful work !

What’s Wrong with NIH Grants? “Science is fundamentally different than remodeling a kitchen”

Very interesting interview

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway Most mammals consume small and frequent meals. By contrast, pythons are ambush predators that exhibit extreme feeding and fasting patterns and provide a unique model for uncovering molecular mediators...

pTOS is the new glp1?

Review @natrevimmunol.nature.com
The immunology of vitiligo
nature.com/articles/s41...

How Dad’s Fitness May Be Packaged and Passed Down in Sperm RNA | Quanta Magazine Research into how a father’s choices — such as diet, exercise, stress, nicotine use — may transfer traits to his children has become impossible to ignore.

Hmmm ... sperm RNAs? Paternal effects? It's like an early Christmas present! Very nice article by Ivan Amato, including quotes and work from some excellent scientists like @colinconine.bsky.social ... and me, as well. ;)

www.quantamagazine.org/how-dads-fit...

AI is Destroying the University and Learning Itself Students use AI to write papers, professors use AI to grade them, degrees become meaningless, and tech companies make fortunes. Welcome to the death of higher education.

“The math is brutal and the juxtaposition stark: millions for OpenAI while pink slips go out to longtime lecturers. The CSU isn’t investing in education—it’s outsourcing it, paying premium prices for a chatbot many students were already using for free.“
www.currentaffairs.org/news/ai-is-d...

Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org

Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org

🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...

Welcome to Bluesky Sam ! here is two Starting PAck lists I made of virologists on Bluesky that you might be interested in following : go.bsky.app/DmphBCT go.bsky.app/6bSDmrW

My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...

Bravo @mkrupovic.bsky.social and team !

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Acidosis orchestrates adaptations of energy metabolism in tumors Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...

Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !