Anabel Chang

Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...

#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes

A card showing James Watson on one side, and the headline "DNA pioneer James Watson has died ― colleagues wrestle with his legacy" on the other

Watson – who won the Nobel Prize for his role in divining the structure of DNA; was instrumental in initiating and propelling the Human Genome Project; and who became notorious for his history of racist and sexist comments – has died at 97

Read the full story: go.nature.com/47NJ6wy

Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol https://www.biorxiv.org/content/10.1101/2025.10.25.684498v1

Prompt used for all LLMs when provided with the scraped HTML homepage.

LLMs can mirror expert judgment but often rely on word patterns rather than reasoning. A new study introduces epistemia, the illusion of knowledge that occurs when surface plausibility replaces verification. In PNAS: https://ow.ly/ry7S50Xcv9b

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on #endosomes. New work from Kevin Swift, Iryna Pustova, Anjon Audhya and colleagues @uwmadison.bsky.social: rupress.org/jcb/article/...

#membrane #lipid

New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...

#membrane #lipid

People arm in arm while drinking coffee and holding papers, with text: Why scientists should take more coffee breaks.

Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕

"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb

Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...

Virulence priming of Listeria monocytogenes inside replication-permissive endolysosomes https://www.biorxiv.org/content/10.1101/2025.09.02.673654v1

Event-triggered MINFLUX microscopy: smart microscopy to catch and follow rare events https://www.biorxiv.org/content/10.1101/2025.08.27.672674v1

Live U2OS cells: G3BP1-GFP + MitoTracker, treated with sodium arsenite. Imaged on Elyra 7. #SuperResolution #Microscopy #CellBiology #LiveCellImaging

Identification of organelle-specific #autophagy regulators from tandem #CRISPR screens. New study from Truc Losier, Karyn King, Maxime Rousseaux, and Ryan Russell (@russellbiolab.bsky.social) @uottawa.ca: rupress.org/jcb/article/...

#Biochemistry #CellSignaling

Refractive index mapping below the diffraction limit via single molecule localization microscopy https://www.biorxiv.org/content/10.1101/2025.08.20.670782v1

NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection https://www.biorxiv.org/content/10.1101/2025.08.16.670319v1

"Overcoming research bias: The untapped potential of biomedically important but understudied proteins" http://dlvr.it/TMXd85

@einsteinmededu.bsky.social Steven Grudman, Carlos Madrid-Aliste and Andras Fiser
@iScience_CP

Yanzhe Zheng et al. reveal that during starvation, SOD1, linked to #ALS, is transported into #lysosomes through #autophagy and the receptor protein TP53INP1. Within lysosomes, SOD1 regulates ROS levels and safeguards lysosomal activity and integrity. rupress.org/jcb/article/...

A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/...

#Technology #Chromatin #epigenetics #CellCycle

Exclusive: NIH suspends dozens of pathogen studies over ‘gain-of-function’ concerns Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists

Exclusive: In response to White House concerns about allegedly risky research on viruses, bacteria, and other pathogens, the National Institutes of Health has begun a crackdown on dozens of studies it was funding, ScienceInsider has learned. scim.ag/44oJIbw

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity - Nature Communications Antisense oligonucleotide (ASO) cellular activity requires endosomal escape. Here, the authors show that disrupting Golgi-endosome protein AP1M1 enhances ASO activity by prolonging ASO endosomal resid...

www.nature.com/articles/s41...

Bacteria that possess a type VI secretion system (T6SS) inject toxins directly into neighboring cells that may be competing for local resources. Toxins break down the cell wall of susceptible cells, causing the release of nutrients that the attacking bacteria can consume for growth and proliferation. However, this can cause spatial segregation of the bacterial cell population, restricting attacks to the boundaries of predator cell groups and prey cell groups. This might limit the number of cells that can leverage the T6SS system for predation.

Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.

Learn more in a new #SciencePerspective: scim.ag/44y3iC6

Targeting de novo purine biosynthesis for tuberculosis treatment - Nature The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.

Nature research paper: Targeting de novo purine biosynthesis for tuberculosis treatment

https://go.nature.com/3SYNS3i

Tanaka, Oide, @tomokokubori.bsky.social, Arasaki et al. reveal that the bacterial pathogen #Legionella pneumophila ubiquitinates Rab5 to recruit a Rab5 inactivator RabGAP-5 to its phagosome, thereby excluding Rab5 and facilitating its intracellular replication. rupress.org/jcb/article/...

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.

A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪