Marco Sciacovelli

Thank you @frances-turrell.bsky.social for a fantastic seminar!

Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer Early-onset colorectal cancer (EO-CRC) occurring in individuals under age 50 is rapidly increasing globally, while the incidence of late-onset colorec…

www.sciencedirect.com/science/arti...

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...

nteresting paper showing how HDAC6 interacts and regulates fumarate hydratase (FH) affecting mitochondrial structure www.nature.com/articles/s41...

Succinate preserves CD8+ T cell fitness to augment antitumor immunity How various tumoral metabolites impact antitumor T cell immunity is an area of active research. Ma et al. demonstrate that succinate enhances mitochondrial fitness and induces epigenetic reprogramming...

Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...

Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...

a young boy is writing on a piece of paper with the words so many papers written on it ALT: a young boy is writing on a piece of paper with the words so many papers written on it

Good Sunday all! A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you! Loads of cool science!! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"You are the sky. Everything else—it’s just the weather."
Pema Chödrön

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Good morning all! There are some wonderful papers in #cancermetabolism and #mitochondrialbiology in this curated issue! Don't miss it, find it here: biomed.news/bims-camemi/... @biomednews.bsky.social
#keepreading

"When you argue with reality, you lose, but only 100% of the time." -Byron Katie

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Good Sunday, all! There are huge discoveries in this curated summary of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"The quieter you become, the more you can hear."-Ram Dass

This week you can join our seminar online @livuni-ismib.bsky.social please check emails for Zoom link Friday

20th June 2025, 11am – 12pm.

Guest Speaker – Max Mazzone
Title – “Harnessing tumor metabolism to overcome immunosuppression”
Host – @mcschmid.bsky.social
Location – Zoom

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming Zhao et al. uncovered a nuclear-restricted acetyl-CoA regulatory mechanism where nucleus-localized pyruvate dehydrogenase complex (nPDC) is constitutively bound and repressed by nuclear protein ELMSAN...

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming: Cell Metabolism www.cell.com/cell-metabol...

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Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

The boundary to what we can accept is the boundary to our freedom.
Tara Brach

Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation - Cancer & Metabolism Increasing emphasis has been placed on improving the physiological relevance of cell culture media with formulations such as Human Plasma-Like Medium (HPLM). Given that shifts in mitochondrial metabol...

cancerandmetabolism.biomedcentral.com/articles/10....

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism Pyruvate and branched-chain amino acid (BCAA) metabolism are pivotal pathways in tumor progression, yet the intricate interplay between them and its i…

Very interesting work about how DLAT suppresses leucine catabolism via acetylation of AUH, ultimately favouring activation of mTOR and hepatic cancer
www.sciencedirect.com/science/arti...

Interested in the interplay between histone supply, epigenetics and cancer biology? This research intensive Masters (MRes) course at the University of Liverpool could be for you! Apply by 29th August 2025. www.liverpool.ac.uk/courses/biol...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...

Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4

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Good Sunday all. Science keeps on delivering beautiful discoveries despite all. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

The time you enjoy wasting is not wasted time.
Bertrand Russell

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Good morning all! Another week has passed, multiple groundbreaking discoveries were made. Don't miss them, find them here: biomed.news/bims-camemi/...
@Bims_BiomedNews #readingtime

And what importance do I have in the courtroom of oblivion?

Pablo Neruda

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites to regulate macrophage immune responses. This review highlights how these metabolites influence cytokine produ...

Very nice review about the role of TCA cycle-linked metabolites in regulating the functionality of macrophages
www.cell.com/cell-metabol...

Keeping a Close Eye on Cancer To understand most stories you should start from the beginning. We’ll explore how some cancers form, whether the gut microbiome could revolutionise the way…

Pint of Science featuring some of staff members:

"Keeping a Close Eye on Cancer"

Keep a look out for tickets (currently sold out!!)

@paulatherton.bsky.social

pintofscience.co.uk/event/keepin...

We have an exciting 2 year postdoc position available in our department in the lab of Marisa Merino - please see advert attached!

Please contact Marisa for more details!

Repost and share as you wish!

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer Branched-chain amino acid (BCAA) catabolism contributes prominently to the TCA cycle in the healthy pancreas but is suppressed in pancreatic ductal adenocarcinoma (PDA). The impact of this metabolic r...

Very cool work about the role of the branched-chain amino acids in regulating transcription in pancreatic cancer via histone propionylation
www.biorxiv.org/content/10.1...

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A belated weekly issue of papers in #cancermetabolism and #mitochondriabiology is ready for you! Check it out here: biomed.news/bims-camemi/... @biomednews.bsky.social

"You have to do nothing to be who you are. Nothing at all."
-H. W. L. Poonja

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Good Sunday, all! Another week, another set of massive discoveries in #cancermatabolism and #mitochondrialbiology! Find them here:

biomed.news/bims-camemi/...

@biomednews.bsky.social #keepreading

Be kind, for everyone is fighting a hard battle.
John Watson

This week @msciacovellilab.bsky.social and @drlornayoung.bsky.social provide an Undergraduate-style lecture to 60+ students visiting from the local region.

All students are on the Liverpool Scholars Programme, in partnership with Widening Participation 🎉

Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion The overall impact of arginine metabolism in tumor progression remains unclear. Using clinical analysis, scRNA-seq, and animal models, Zhu et al. identify cancer cell-macrophage metabolic interplay as...

Very interesting paper about the metabolic crosstalk that involves arginine between breast cancer cells and tumour associated macrophages www.cell.com/cancer-cell/...

Lactate controls cancer stemness and plasticity through epigenetic regulation Using fluorescent reporters and machine learning, Nguyen et al. traced cell types, metabolism, and lineages in tumor organoids, revealing that lactate regulates tumor development by inhibiting cancer ...

Very interesting paper about lactate, epigenetic reprogramming and stemness in intestinal tumours www.cell.com/cell-metabol...

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites to regulate macrophage immune responses. This review highlights how these metabolites influence cytokine produ...

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation: Cell Metabolism www.cell.com/cell-metabol...

Thank you @loverna.bsky.social for inviting me to present my past and future work on cancer metabolism and signalling at @qmbci.bsky.social. It was great to see your work and have so many interesting conversations.

Engineering mtDNA deletions by reconstituting end joining in human mitochondria Combined expression of a mitochondrially targeted endonuclease and end-joining machinery enables formation of mtDNA deletions with a broad range of heteroplasmy.

Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...