John Witte's Avatar

John Witte

@johnwitte.bsky.social

Professor @Stanford Epidemiology, Genetics, & Data Science Stanford Cancer Institute ++ data, colleagues, family & friends

142 Followers  |  135 Following  |  2 Posts  |  Joined: 02.11.2023  |  1.4638

Latest posts by johnwitte.bsky.social on Bluesky

Preview
Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ...

Our latest preprint revisits the classic model of mutation-selection balance.

Do human recessive genes fit Haldane's 100-year old model?

This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io

www.biorxiv.org/content/10.6...

13.12.2025 16:45 β€” πŸ‘ 113    πŸ” 52    πŸ’¬ 4    πŸ“Œ 5

Yes I’m here for the term. Will see you shortly!

03.11.2025 10:29 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Looking forward to your talk!

03.11.2025 09:46 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
The PRIMED Consortium: Reducing disparities in polygenic risk assessment By improving disease risk prediction, polygenic risk scores (PRSs) could have a significant impact on health promotion and disease prevention. Due to …

Check out the latest review on PRS assessment from the #PRIMEDConsortium

πŸ‘‡πŸ‘‡πŸ‘‡πŸ‘‡

www.sciencedirect.com/science/arti...

18.11.2024 20:41 β€” πŸ‘ 24    πŸ” 13    πŸ’¬ 1    πŸ“Œ 0

@johnwitte is following 20 prominent accounts