Piper Below

Large-scale genome-wide analyses of stuttering - Nature Genetics Genome-wide analyses in over one million self-reported cases and controls identify genetic variants associated with stuttering and find genetic correlations with autism, depression and impaired musica...

📢PUBLISHED @natgenet.nature.com

📰Large-scale genome-wide analyses of stuttering.

By Hannah G. Polikowsky, Jennifer E. Below and colleagues.

⬇️

www.nature.com/articles/s41...

Large-scale study uncovers 57 genetic hotspots into stuttering origins Findings published in Nature Genetics point to 48 genes associated with stuttering and highlight neurological pathways of risk.

fascinating and huge study into the origins of stuttering

I've been anxiously awaiting this @natgenet.nature.com piece from @piperbelow.bsky.social to publish!

news.vumc.org/2025/07/28/l...
🧪🧬

there are clips of the researchers talking about the findings and an animated vid w/study highlights

Update This is "Update" by Kindea Labs on Vimeo, the home for high quality videos and the people who love them.

Check out our new work! vimeo.com/1104948937/0...

Large-scale genome-wide analyses of stuttering - Nature Genetics Genome-wide analyses in over one million self-reported cases and controls identify genetic variants associated with stuttering and find genetic correlations with autism, depression and impaired musica...

Exciting paper on genetic influences on speech fluency, out now in @natgenet.nature.com. In a big step forward for the field, genome scans of almost 100,000 people with self-reported stuttering, & 1 million controls, identify 57 associated loci. Great work by @piperbelow.bsky.social & her team.🗣️🧬🧪

Genome-wide study makes ‘quantum leap’ in understanding stuttering Analysis of DNA from 23andMe users points to variants in genes linked to brain function and sense of rhythm

Thanks to @aaas.org for covering our paper! www.science.org/content/arti...

Large-scale study uncovers 57 genetic hotspots into stuttering origins Findings published in Nature Genetics point to 48 genes associated with stuttering and highlight neurological pathways of risk.

Trainees Dillon Pruett and Alyssa Scartozzi, who helped lead this research, are featured in a discussion of our work in this #VUMC Reporter article: news.vumc.org/2025/07/28/l...

This work was led by exceptional grad students and an amazing post doc, Dillon Pruett, who is about to launch his own lab at FSU! We also worked with the talented people at kindealabs.com to make a video that summarizes our work! We hope you will check it out!

Large-scale genome-wide analyses of stuttering - Nature Genetics Genome-wide analyses in over one million self-reported cases and controls identify genetic variants associated with stuttering and find genetic correlations with autism, depression and impaired musica...

Stuttering is the most common speech fluency disorder and is as heritable as many common complex traits. Yet, genetic research of stuttering has lagged behind other human traits. In collaboration with #23andme we conducted the first large-scale GWAS of stuttering. www.nature.com/articles/s41...

“With these considerations, we expect to fund through the 4th percentile.”

There it is, in black and white, the destruction of cancer research in the US.

Curious what people think - is this obvious? Surprising? Important to show? @jahemker.bsky.social in our lab checked whether long reads solve the problem of detecting CNVs and found that yes they do better than short reads but if you want to do well your reads need to be ULTRA long not just long1/n

I’ve never even considered using AI in my writing, but just six grants a year!? I feel targeted.

grants.nih.gov/grants/guide...

Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.

NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.

NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.

The July 2025 Pre-Conference Edition of our newsletter is out! Read it for the latest news from IGES and more details about our upcoming Annual Meeting and Education Workshop.

👉 iges.memberclicks.net/assets/2025_...

I watched the greatest Superman, Christopher Reeve, deliver this speech about what "family values" really means at the 1996 DNC in Chicago.

St. Olaf Tenure Track Search for a Neuroendocrinologist

🚨We're hiring!🚨 St. Olaf is launching a new Neuroscience Major and seeks a tenure-track neuroendocrinologist to help shape its future 🧠✨ Passionate about inclusive teaching, research, and mentoring at a SLAC? Join us! #NeuroJobs @animbehsociety.bsky.social @neuroethology.org ‪@sbn-bsky.bsky.social‬

Congrats, I’m so proud to have been your classmate!

🤡 Was nice to see your (not clown) face for study section, hope you got a chance to unwind after two long days!

Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...

Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank - PubMed Sex chromosome trisomies (SCT) are the most common whole chromosome aneuploidy in humans. Yet, our understanding of the prevalence and associated health outcomes is largely driven by observational stu...

pubmed.ncbi.nlm.nih.gov/39974076/

FIMM-EMBL Group Leaders in Molecular Medicine FIMM-EMBL Group Leaders in Molecular Medicine

We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

What a great looking conference!!

Thank you!!

Jennifer Below named director of Vanderbilt Genetics Institute Jennifer (Piper) Below, PhD, of Genetic Medicine, has been named director of the Vanderbilt Genetics Institute.

news.vumc.org/2025/03/19/j... This is the greatest honor of my career!

❤️So true.

And reminds me of Nancy Cox's @geneticssociety.bsky.social Presidential Lecture: Checking, Balancing, and Celebrating Diversity: Celebrating Some of the Women Who Paved the Way

A FAQ on federal research cuts ...

I wrote up an FAQ about the recent federal grant cuts. A few points: 🧵

$20 million grant supports sweeping study of human viruses A Vanderbilt University Medical Center research team will venture to broadly characterize the role of viruses in human health and disease.

Excited to help lead the data analysis and submission core for this exciting project. news.vumc.org/2025/01/23/2...