Lucien Weiss

Continuous mass photometry by single molecule trapping https://www.biorxiv.org/content/10.64898/2026.02.02.703204v1

Ragaller, F., Sjule, E., Urem, Y. B., ..., Blom, H., & Sezgin, E. (2024). Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements. The journal of physical chemistry. B, 128(9), 2154–2167. #EpithelialMechanics
buff.ly/YjCWSfP

A protein called Uninflatable acts as a switch between glial cells growing and glial cells wrapping themselves around axons.

🔗 buff.ly/WRdybO3

Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.

Its binding turns on and off with a magnet.

This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.

New paper from @zhixingchen2.bsky.social's lab!

It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!

www.nature.com/articles/s41...

New paper out! Combining single-objective light-sheet microscopy and time-resolved SPAD array detection, we massively accelerate fluorescence lifetime imaging (FLIM) compared to confocal FLIM, making FLIM applicable to 3D specimen such as organoids and embryos.
www.nature.com/articles/s42...

The new version of TrackMate, the v8.1 has just been released. It builds upon the recent v8, linked below, and offers two main improvements 👇

📢 Paper alert 📢

Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:

doi.org/10.1038/s415...

Here comes a 🧵 ... (1/9)

StayRose: A photostable StayGold derivative redshifted by genetic code expansion Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence engineering, addresses thi...

Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...

Just published in Nat. Neurosci.

Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.

@erzimmer.bsky.social
@natureportfolio.nature.com

www.nature.com/articles/s41...

Language Models are Injective and Hence Invertible Transformer components such as non-linear activations and normalization are inherently non-injective, suggesting that different inputs could map to the same output and prevent exact recovery of the in...

I did not expect that: Large Language Models are invertible:

arxiv.org/abs/2510.15511

Figure showing that tagged tubulin is frequently incorporated into the OF tip in cells that are in G1-phase.

Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Sub-10 nm upconversion nanocrystals for long-term single-particle tracking - Nature Communications This study presents ultrasmall, bright lanthanide-doped upconversion nanoparticles that overcome surface quenching, enabling high spatiotemporal resolution tracking of membrane proteins with exception...

www.nature.com/articles/s41...

Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com

PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging

Neat - 'bubble-driven cell detachment'
from Kripa Varanasi and co.
doi.org/10.1126/scia...

Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...

I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.

"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆

The culmination of many years work. One of the most advanced light-sheet microscopes in the world!

-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!

For details see previous posts and here: github.com/amsikking/HT...

RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.

Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!

Check it out: lnkd.in/eiUFfJaM.

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...

Ångström-tunable polarization-resolved solid-state photon sources - Nature Photonics A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwid...

New article online: Ångström-tunable polarization-resolved solid-state photon sources.

go.nature.com/4gdVWYR

Reconstructing long-range axons from dense brain images is tough.

This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM

Extreme-ultraviolet spatiotemporal vortices via high harmonic generation - Nature Photonics The generation of spatiotemporal optical vortices in the extreme-ultraviolet regime is demonstrated via high harmonic generation. Topologically coupled at the nanometre and attosecond domains, these l...

New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.

go.nature.com/4m0Tc2e

Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods!
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...

a blue sign that says we are hiring ALT: a blue sign that says we are hiring

There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...

How Easy Is It to Learn Motion Models from Widefield Fluorescence Single Particle Tracks? Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analy...

Can we learn motion models from post-processed tracks? 🧐
Not really 😢

Emission noise accounts for ~99% of the likelihood.

TLDR: What you think is anomalous diffusion… might just be noise. 🤷‍♂️🤷‍♂️🤷‍♂️🤷‍♂️

🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599

#Biophysics