Lucien Weiss

Figure showing that tagged tubulin is frequently incorporated into the OF tip in cells that are in G1-phase.

Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei.
#JCSciliaSI
journals.biologists.com/jcs/article/...

Sub-10 nm upconversion nanocrystals for long-term single-particle tracking - Nature Communications This study presents ultrasmall, bright lanthanide-doped upconversion nanoparticles that overcome surface quenching, enabling high spatiotemporal resolution tracking of membrane proteins with exception...

www.nature.com/articles/s41...

Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com

PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging

Neat - 'bubble-driven cell detachment'
from Kripa Varanasi and co.
doi.org/10.1126/scia...

Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉
publicationsduquebec.gouv.qc.ca/fileadmin/ga...

I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.

"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆

The culmination of many years work. One of the most advanced light-sheet microscopes in the world!

-> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections!

For details see previous posts and here: github.com/amsikking/HT...

RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.

Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!

Check it out: lnkd.in/eiUFfJaM.

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications
academic.oup.com/braincomms/a...

Ångström-tunable polarization-resolved solid-state photon sources - Nature Photonics A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwid...

New article online: Ångström-tunable polarization-resolved solid-state photon sources.

go.nature.com/4gdVWYR

Reconstructing long-range axons from dense brain images is tough.

This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
buff.ly/OBKr9cM

Extreme-ultraviolet spatiotemporal vortices via high harmonic generation - Nature Photonics The generation of spatiotemporal optical vortices in the extreme-ultraviolet regime is demonstrated via high harmonic generation. Topologically coupled at the nanometre and attosecond domains, these l...

New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation.

go.nature.com/4m0Tc2e

Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods!
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...

a blue sign that says we are hiring ALT: a blue sign that says we are hiring

There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...

How Easy Is It to Learn Motion Models from Widefield Fluorescence Single Particle Tracks? Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analy...

Can we learn motion models from post-processed tracks? 🧐
Not really 😢

Emission noise accounts for ~99% of the likelihood.

TLDR: What you think is anomalous diffusion… might just be noise. 🤷‍♂️🤷‍♂️🤷‍♂️🤷‍♂️

🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599

#Biophysics

Khatuli. Cat, engineer, entrepreneur.

Our resident mischief engineer/entrepreneur, Khatuli!

Three-dimensional optofluidic control using reconfigurable thermal barriers - Nature Photonics A fluidic system with spatially reconfigurable hot spots generated by optical pumping of plasmonic nanorods is demonstrated, creating virtual barriers by generating local heating via photothermal conv...

It's out & hot 🔥 Not only because it just went online but since we show that engineered heat patterns are super effective in manipulating fluid flows & particles.
If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read!
www.nature.com/articles/s41...
🧪💡

New open access article online: Microscale generation and control of nanosecond light by light in a liquid crystal.

go.nature.com/3H0mT5a

Super-resolution live-cell mapping of protein-protein interactions using chemogenetic split reporters and STED microscopy https://www.biorxiv.org/content/10.1101/2025.08.05.668682v1

#PALH: How to convert a #3Dprinter to a personal #automated #OpenSource #liquid #handler for life #science workflows:

- based on #Ender3
- cost: US $400
- #PCR setup, #DNA purification using #magnetic beads

doi.org/10.1016/j.sl...
#DIYbio #DIYchem #chemistry #lab #instruments #pipet #automation

Metabolically Labeled CAR-T Cells Against Cancer Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to…

Wyss scientists have invented a novel metabolic labeling technology that enables the “tagging” of the surface of T cells with immune-enhancing cytokine molecules, which could help expand adoptive T cell therapies to the treatment of solid tumors.

Ångström-resolution imaging of cell-surface glycans

Now published in Nature Nanotechnology! 🤩
@natnano.nature.com

www.nature.com/articles/s41...

Pieces of the puzzle coming together: Researchers report #Parkinsons-associated GBA1 mutations impair Sonic Hedgehog signaling & Hedgehog-dependent neuroprotective factor production by a distinct mechanism
www.pnas.org/doi/10.1073/...

GitHub - QI2lab/opm-processing-v2: Code for fast deconvolution, deskewing, registration, and fusion of OPM/diSPIM/LLSM data. Code for fast deconvolution, deskewing, registration, and fusion of OPM/diSPIM/LLSM data. - QI2lab/opm-processing-v2

Tensorstore is much faster for read/write than vanilla zarr. Tools are here: github.com/QI2lab/opm-p...

Currently we only support our custom pymmcore-plus OPM format and ASI’s OPM format. Happy to work with you to support CZI LLSM files if you open an issue and provide some example data.

Microfluidic generation of bacterial biohybrids for magnetic guidance and content release Bacterial biohybrids use bacterial and synthetic components for biotechnological applications. Here, we outline an adaptable and high-throughput microfluidic platform to create microscale biocontained...

🎉Just out in @chemcomm.rsc.org! We present a modular strategy to create bacterial #biohybrids with magnetic motility, #biosensing and cargo release.
👏🏻huge congrats to Nina on her first first-author paper and thanks to Yuval and Matt for the great collaboration! pubs.rsc.org/en/content/a... @rsc.org

Researchers introduce UltraID-LIPA, an innovative platform that combines the light-inducible protein aggregation (LIPA) system with the UltraID proximity-dependent biotinylation assay to identify #Parkinsons-associated α-synuclein-interacting proteins
www.cell.com/iscience/ful...