Stephen Royle

In desperation, I did. No joy. I tried perplexity but maybe there are better options.

There's a paper that I am sure exists but I cannot find it via searching. Starting to wonder if I imagined it. Who needs LLMs to hallucinate references when I can do it all by myself?

#LifeOfPI

Oh, I hadn’t already done the review. I was just logging in to accept the invitation. So I’m ok with it!

Yeah, that word stood out to me as well.

Screenshot at Review Commons that says "Thank you for your time, but unfortunately we already have enough Reviewers for this manuscript"

Off the hook... 😅 #LifeOfPI

Applications for ERC Synergy Grants 2026: Facts and figures The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:

957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...

Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation. Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...

Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...

CBIAS napari workshop 2025

📢 Enhance your bioimage analysis skills - 2-day hands-on napari workshop.

Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance

📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

Publishers being very naughty with retractions...

I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)

What on earth took so long??

New user experience · Issue #886 · napari/docs 📚 New content request Review tutorials from the perspective of a new user (perhaps a wet lab scientist). Outline I wrote a short post on my experience using napari seriously for the first time (I h...

Yes, sure. Thanks, Tim.
github.com/napari/docs/...

I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.

quantixed.org/2025/11/04/a...

In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.

#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!

Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.

Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella

journals.biologists.com/jcs/issue/13...

I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.

The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.

LLMs mean it makes even more sense 1/2

Our new paper on type VII - showing a role in delaying macrophage death-

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

The image shows two cytofluorograms for the same two images, the left one built with linear axes and the right one with logarithmic axes.

How a trick from flow cytometry can help colocalization visualization for microscopy forum.image.sc/t/cytofluoro...

Yeah I'm not sure where this issue comes from. It's quicktime I guess but it seems to affect different codecs and containers to different extents.

Sequoia 15.6 on Powerpoint on MAC STILL pixelating and glitching LOOPED videos - Microsoft Q&A BEYOND pathetic at this point. This happened last year, then they fixed it. Then it happened in Sequoia 15.5 -- and 15.6 didn't fix it. I feel it's a MacOS issue, but where is MS in all this. Is Apple...

Oh and proof it's not just me with this issue!

learn.microsoft.com/en-us/answer...

use GIFs!

rename `mytalk.pptx` to `mytalk.zip`
Unzip
cd to mytalk/ppt/media

for i in *.mp4; do
ffmpeg -i "$i" "${i%.mp4}.gif"
done

Add gifs in place of original movies. They loop perfectly.
The ffmpeg command can be customised to improve quality.
2/2

There's a year-old problem with looping movies in Powerpoint on Mac. Movie plays once, jitters and then shows blocky artefacts. Same pptx works fine on Windows. Problem seems to be Mac-side (QT?) but 15.7.1 and 26.0.1 both show this behaviour.

A solution, in case it helps anyone:
1/2

Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.

Beautiful. I was on that bridge yesterday taking photos but it was very cloudy and grey. Picked the wrong day, obviously!

7

November'25-February'26 membrane trafficking online seminars program

Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !

With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2

Will Scott smiling with a pipette in the lab

Read more about this research in our interview with first author Will Scott, a postdoc fellow in Mohan Balasubramanian's lab at University of Warwick, UK, interested in engineering proteins and synthesising organic molecules to tackle actin cytoskeleton-associated challenges. doi.org/10.1242/bio....

As part of our monthly meeting, we do a run-down of all* the new #bioimageanalysis tools that have been published in the last couple of weeks on BioRxiv**, so I thought I'd start sharing here as well.

*I will miss some, apologies if I miss your paper