David Mick

Monoclonal antibodies revolutionized biomedical science and health care The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.

'This story shows that it is possible to establish a multibillion-dollar industry purely by letting scientists communicate their research, exchange information and share materials.'
www.nature.com/articles/d41...

Science doesn’t need to be pretty and go according to plan; it just needs to lead to a discovery. If doesn’t have to be done alone or together with someone else; there just needs to be a discovery. It doesn’t need to happen fast or slow; just as long as there’s a discovery, then everybody is happy.

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

Head of the Cell Biology and Biophysics Unit The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

This is figure 2 showing how SNAP-tag engineering is aiming for faster and brighter fluorescence labeling

SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪

Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...

Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia

Looks beautiful, indeed. Say hi to John and Robin!

Re-growing adult organs: mothers do it best - the Node Tomotsune Ameku tells the story behind the paper "Growth of the maternal intestine during reproduction"

'Reproductive-associated changes are also known to occur at the organ level, in particular, an increase in intestinal size during pregnancy and lactation has been observed in several mammals such as mice, rats, sheep, and pigs'
thenode.biologists.com/re-growing-a...

@sven-m-lange.bsky.social @alanbrownhms.bsky.social epic preprint dropped last night 🔥🔥🔥 #cilia #ift #ubiquitin #compartmentalization #signaling #GPCRs #AnticipationBuilding #SlowRead 🧪 www.biorxiv.org/content/10.1...

Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org

Congrats James! Well deserved!

Mark your calendars & repost! Join us for the 2026 FASEB Lipid Droplets Conference!

July 26-30, 2026 in beautiful Scottsdale, Arizona.

Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities brought together!

Congrats Pleasantine! Very well deserved!

Fantastic lineup again. Can't wait!

I miss Freiburg. Should visit our fantastic collaborators there soon.

NIH cancels funding for landmark diabetes study at a time of focus on chronic disease The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said.

“The Trump administration has canceled funding for an ongoing 30-year, nationwide study tracking patients with prediabetes and diabetes, researchers said, at a time when top officials have emphasized their determination to curb the incidence of such chronic conditions.”

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...

A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis https://www.biorxiv.org/content/10.1101/2025.03.10.642408v1

Congrats all! What a great first bsky post!

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...

Our first post on Bluesky!
1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins.
www.biorxiv.org/content/10.1...

Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!

Happy faces and a lot of sunshine at the start of our Spring School on #cilia dynamics! @jayccblab.bsky.social @nathaliejuya.bsky.social @mick-lab.bsky.social @wachtenlab.bsky.social Looking forward to three days of interactions with early career researchers from our cilia network partners!

Congrats Claudia! Keep up the good work!

‘Free world needs a new leader’, says EU foreign chief after Trump Zelenskyy row The EU foreign policy chief, Kaja Kallas, said ‘the free world needs a new leader’ and that it was up to Europeans to take this challenge

The EU foreign policy chief has declared that “the free world needs a new leader”, as European leaders threw their support behind Ukraine’s president, Volodymyr Zelenskyy.

www.theguardian.com/world/2025/f...

Nice work on one of my most favorite topics.

Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload - Nature Chemical Biology A small-molecule agonist of transient receptor potential cation channel subfamily M member 4 persistently activates the ion channel and induces necrosis characterized by sodium overload.

A small-molecule agonist of TRPM4 persistently activates the ion channel and induces necrosis characterized by sodium overload

www.nature.com/articles/s41...

Quantitative chemoproteomics reveals dopamine’s protective modification of Tau - Nature Chemical Biology Wang et al. develop data-independent acquisition activity-based protein profiling, a quantitative chemoproteomic method to globally profile protein dopamination in the mouse brain, and identify a prot...

Chemoproteomic profiling of protein dopamination in the mouse brain reveals a protective role of dopamine in regulating the function of microtubule-associated protein Tau

www.nature.com/articles/s41...

Cannot agree more. We do lots of proteomics and show GOterms if reviewers ask for it. Insight from GOterm enrichment analysis is often limited. If you don't have time to look at data, are not interested, or don't understand it, please don't GO there. Cheers!

Wow. 👀📌

Cool organelle segmentation tool. Time to try it out. Congrats all!