@osamuri.bsky.social
A postdoc in Ivan Ahel group, Sir Willam Dunn School of Pathology, University of Oxford. #Drosophila #ADPribosylation
Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...
New paper! We uncover mechanistic insights into the crosstalk between AHR (aryl hydrocarbon receptor, a transcription factor) and PARP7 (a nuclear enzyme that performs protein ADP-ribosylation). Both are promising cancer drug targets.
Big thanks to all co-authors!
www.pnas.org/doi/10.1073/...
The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Liz Robertson to the left, text to the right 100 extraordinary biologists Liz Robertson Having been a Development Editor since 2003, Liz Robertson is the longest-standing Editor of The Company of Biologistsβ journals still in service. She has also been a prolific Development author since 1983. Lizβs lab at the University of Oxford, UK, studies signalling and gene expression in early mammalian development. #100biologists #biologists100
We are highlighting Liz Robertson, @dev-journal.bsky.social Editor and the longest-standing Editor of @biologists.bsky.social journals, as an extraordinary biologist this week.
#100biologists
We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...
Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.
#ADPribosylation #ubiquitination #MARUbylation #crosstalk
authors.elsevier.com/sd/article/S...
We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com
Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable
#MARUbylation:
@michaelnadbio.bsky.social @jnpruneda.bsky.social and colleagues find that IFN-Ξ² induces the novel post-translational modification, mono-ADP-ribosyl ubiquitylation, on several interferon-stimulated #PARPs such as PARP10, PARP7 and PARP14
www.embopress.org/doi/full/10....
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. β¬οΈ
www.cell.com/cell-reports...
Potential PhD students who are interested in working in Ivan Ahel group are welcome to apply through the ILESLA programme.
#ADPribosylation
@dunnschool.bsky.social
@ox.ac.uk
iles.web.ox.ac.uk/how-apply
We just can't stop recruiting!
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
π£ Please share: Weβre hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
16.12.2024 11:50 β π 110 π 118 π¬ 4 π 7
We are advertising for a project looking at epigenetic inheritance in Drosophila at the Department of Biology, University of Oxford @oxfordbiology.bsky.social Please get in touch if you are interested! Only 1 month left to be considered for funding.
www.findaphd.com/phds/project...
Intriguing new paper by @mflangelier.bsky.social in the Pascal lab showing that PARP1 can generate free poly-ADP-ribose (PAR) (not attached to proteins) in vitro and in cells. In some cases PAR is attached to NAD+! #PARP #ADP-ribosylation #NAD+
www.cell.com/molecular-ce...
Cover of PLoS biology showing fruit fly wing discs stained for Wingless protein, cell death, and the anterior compartment market Ci
More #drosophila work, recently in @plos.bsky.social PLOS Biology (on the cover :))
βWnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathwayβ Ewen-Campen & Norbert Perrimon
journals.plos.org/plosbiology/...
interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social
go.bsky.app/CiRKAXJ
Important so please help spread the word...
Interested in postgrad research? Maybe do a PhD?
Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds
Stipend, free accommodation, mentoring...
Deadline 21 Feb
www.ox.ac.uk/admissions/g...
