Andreas Ingham's Avatar

Andreas Ingham

@andreasingham.bsky.social

PhD fellow at the Mailand lab. Interested in histone transcription, but also follow any climbing-related content

146 Followers  |  534 Following  |  1 Posts  |  Joined: 30.11.2024  |  1.5157

Latest posts by andreasingham.bsky.social on Bluesky

Preview
CRAMP1โ€™s surprising grip on linker histones In this issue of Molecular Cell, Ingham et al. and Matthews et al. report CRAMP1 as a key regulator of linker histone transcription in human cells.

CRAMP1โ€™s surprising grip on linker histones

09.07.2025 11:33 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...

Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...

19.06.2025 06:39 โ€” ๐Ÿ‘ 7    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP1-dependent H1 synthesis induces excessive demand for topoisomerase II activity in low-accessibility chromatin states, thereby increasing sensitivity to TOP2 inhibitors.

Online Now: CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Online now:

13.06.2025 15:19 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@andreasingham is following 20 prominent accounts