Andreas Ingham

"Evolutionarily conserved regulation and functions of H1 linker histones in development"
by Lu Wang & colleagues

"Collectively, this overview positions H1 and its master regulator CRAMP1 as important players in chromatin organization..."

FREE till March 27th at
authors.elsevier.com/a/1mZUI_3rsx...

Stunning work, Kumar - congratulations!

Congratulations Ernst, remarkable work

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Beautiful work, Susi!

What specific targets & roles are there for all distinct polyubiquitin chain types?
Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization
www.embopress.org/doi/full/10....

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

CRAMP1’s surprising grip on linker histones In this issue of Molecular Cell, Ingham et al. and Matthews et al. report CRAMP1 as a key regulator of linker histone transcription in human cells.

CRAMP1’s surprising grip on linker histones

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...

Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP1-dependent H1 synthesis induces excessive demand for topoisomerase II activity in low-accessibility chromatin states, thereby increasing sensitivity to TOP2 inhibitors.

Online Now: CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance Online now: