Postdoctoral Fellow - Costa Lab Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity.
my.corehr.com/pls/uoxrecru...

Colin Kleanthous' fundraiser for Motor Neurone Disease Association Help Colin Kleanthous raise money to support Motor Neurone Disease Association

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k...
(Please repost!)

Regulation of a phage defence island by RptR, a novel repressor that controls restriction–modification systems in diverse bacteria Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th

Defence island in Escherichia coli composed of DarTG toxin-antitoxin system embedded within a Type I restriction-modification system is regulated by the RptR (RMS-proximal transcriptional regulator).
academic.oup.com/nar/article/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Our review article 'PARPs and ADP-ribosyl hydrolases in cancer therapy: from drug targets to biomarkers' is now available online.
doi.org/10.1016/j.dn...

We have a postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability and/or immunity. Expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

New paper! We uncover mechanistic insights into the crosstalk between AHR (aryl hydrocarbon receptor, a transcription factor) and PARP7 (a nuclear enzyme that performs protein ADP-ribosylation). Both are promising cancer drug targets.

Big thanks to all co-authors!

www.pnas.org/doi/10.1073/...

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety onto proteins related to immunity, transcription, and cell g...

Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.

my.corehr.com/pls/uoxrecru...

⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford.

We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport.

❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬

30/5/25 ➡️ tinyurl.com/KToropovaPDRA

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...!

Many thanks to all the groups involved:
@clausenlab.bsky.social
@e3chembio.bsky.social
@fletcherlab.bsky.social

Have a look at the summary from Fletcher lab for an insider perspective of the paper's history:

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose Crosstalk between the post-translational modification processes ubiquitination and ADP-ribosylation occurs in DNA-damage and immune-responses, in addition the physical linkage of ADP-ribose and ubiqui...

This new paper in collaboration with the lab of Gerbrand van der Heden van Noort is a natural follow-up describing a ADPr-Ub reader protein: www.biorxiv.org/content/10.1...

A few years back we discovered a novel dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub):
pubmed.ncbi.nlm.nih.gov/36197986/

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...