Esashi Lab

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

Thanks so much for coming, Sarah! We loved your talk - super exciting and inspiring. Can’t wait to catch up soon!

Huge thanks to everyone involved and for the incredible support from the community.

This is our very first post on this platform, and we're looking forward to continuing to connect with you all!

This study, conceived eight years ago, was made possible by a global collaboration across the UK, USA, Japan and Turkey. The dedicated team efforts of Emily and Lucia, relayed by Brian, Jacob, Emoke and Ramazan, and invaluable assistance from many others, brought this research to life.

Note that the phenotype varies between cell lines (HCT116 vs RPE1), but in the big picture, we propose that homologous recombination and mismatch repair factors engage in a ‘tug of war’ at centromeres to maintain their functional resilience.

The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous cells through distinct mechanisms, partly counteracting the mismatch repair factor MLH1. In cancer cells, B...

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️

www.cell.com/cell-reports...